In a global effort to understand gene function, the IMPC is collecting phenotype data of knockout mice at the embryo, early adult and late adult life stages. Phenotype data is collected following standardized phenotyping pipelines, as described in IMPReSS, which determines what procedures are performed, how and when.
Selected mouse lines enter the ageing pipeline, in which specimens are aged to see gene knockout effects later in life. The Late Adult pipeline is based on the Early Adult pipeline, with exclusion of some procedures. For example, hearing based tests can be excluded due to deafness in the baseline. The testing for the Late Adult pipeline starts at 52 weeks or later. An “early adult” specimen is less than 16 weeks of age, a “middle aged adult” comprises mice between 16 and 48 weeks of age, and a “late adult” is more than 48 weeks of age. A description of all pipelines can be found here.
The diagram below shows the procedures that are applied to aged mice and all mouse lines for which the IMPC has collected ageing data up to now. You can scroll down or use the box on the right-hand side to look for your gene of interest. Clicking on the procedure name changes the diagram view to show the underlying parameters, and you can return to the default view by clicking on the header. Clicking on a cell opens up the “All data table” in the Gene page, filtered for the selected late adult procedure or parameter, in order to view the underlying data and the statistical tests that were applied.
IMPC uses most recently approved gene symbols. Please use the search box above to find current gene symbols for synonyms, MGI identifiers, or to find the mouse orthologue if you have a human gene symbol.