Embryo Viewer

Up to one third of homozygous mouse knockout lines are embryonic lethal. Therefore, a systematic unbaised phenotyping pipeline was established to morphologically evaluate mutant embryos to ascertain the primary perturbations that cause their death and gain insight into gene function.

As determined in IMPReSS (see interactive diagram here), all embryonic lethal lines undergo gross morphology assessment at E12.5 to determine if defects occur earlier or later in development. A comprehensive imaging platform is then used to assess dysmorphology at the most appropriate stage. Embryo gross morphology and 2D and 3D imaging is actively being obtained by the IMPC for embryonic lethal lines.

Read more in our paper on High-throughput discovery of novel developmental phenotypes, Nature 2016

Images acquired by micro-CT and OPT

Gene OPT E9.5 MicroCT E14.5-E15.5 MicroCT E18.5
1700003F12Rik  
4932438A13Rik  
Abca1  
Acan    
Acat2  
Ace  
Actg1  
Acvr2a  
Acvr2b  
Adam23  
Aebp1  
Ahnak  
Akap10  
Aldh1a3  
Ampd1  
Ampd2  
Anapc15  
Anks3  
Ano6  
Ap2b1  
Ap4e1  
Apbb2  
Arhgap33  
Arhgef18    
Arih2  
Arl15    
Atf4  
Atg13    
Atg3  
Atp1a3    
Atp2a1    
Axin2  
B3galnt2  
BC053393  
Baiap2  
Barx2  
Bbox1    
Bcl11b  
Bcl7a  
Bclaf1  
Best2  
Bicdl1  
Bloc1s2  
Bmi1  
Bscl2  
Cacna1s    
Casq2  
Casz1  
Cbx2  
Cbx4  
Ccdc114  
Ccnt2  
Cdc34  
Cdk19  
Cdk4  
Cdkn1c  
Cecr2  
Cep164  
Cep97  
Cgn    
Chic2  
Chpt1  
Chrnb2  
Chst14  
Chtf18  
Ckap4  
Clcf1  
Clcn3  
Cldn1  
Cnnm2  
Cnp  
Cnr1  
Commd9  
Coq2  
Cox7c  
Cps1    
Creb3  
Crispld2  
Cst3  
Ctdspl2  
Ctnnbip1  
D1Ertd622e  
Daam1  
Dbn1      
Dcc  
Depdc5    
Dlg5  
Dnal1  
Dnm1  
Dok7  
Dpm2  
Dpy19l1  
Dsc3    
Dst  
Ecm1  
Egr1  
Elmod2  
Emc8  
Epas1  
Epb41  
Ethe1  
Ewsr1  
Exoc6  
Eya1  
Eya4  
F10  
F2  
F7  
Fadd  
Fam13b  
Fam20c  
Fam49b  
Fbxl16  
Fbxl20  
Fbxl21    
Fbxo11    
Fbxo30  
Fermt3  
Fgf10    
Fgf15  
Fgf3  
Fgf8  
Fgf9    
Flnb  
Flywch1  
Fmc1    
Fmnl3  
Fndc3b  
Foxj3  
Foxp1  
Frmd6  
Frrs1l  
Fscn1  
Furin  
Fus  
Fzd3    
Fzd4  
Fzd5  
Fzr1  
Gabarapl2  
Gabpa  
Gata2  
Gck    
Gdpd5  
Gfi1b  
Gfod2  
Gfpt1  
Ggnbp2  
Gjb3  
Gjc1  
Gm572  
Gna11  
Gnao1    
Got1  
Gramd1b  
Grcc10  
Gyg    
Hap1  
Hipk2  
Hmga1  
Hmgn2  
Hnrnpab  
Hoxb13  
Hpse2  
Inpp5e  
Ints12  
Ippk  
Irx1    
Itpr1  
Jag2    
Jup  
Kcnj10    
Kcnj13  
Kctd15  
Kdm8  
Kif1b  
Kif26b  
Kif3c  
Kif5a  
Klf7    
Klhdc2    
Krt5  
L3mbtl3  
Lama5    
Laptm4b  
Ldb3    
Lefty1    
Lgi4  
Lhx6  
Lifr  
Lpar1  
Lpgat1  
Lrrc8a  
Lum  
Map3k12  
Map3k7  
Mbd6  
Mboat7  
Memo1  
Mfsd2a  
Micu1  
Mllt3  
Mmachc  
Mob2  
Mrpl23  
Myb  
Myo18a  
Myo1h  
Nabp2  
Nalcn  
Ncbp3    
Ncoa3  
Ndel1    
Nedd4l  
Nek7  
Nemf  
Ngfr  
Nhlh1  
Notch1  
Npc1  
Nr1d1    
Nr2f1  
Nras    
Nrxn1  
Nsd3  
Ntrk1    
Ntrk2    
Nxn    
Otub1  
Otud4  
Otud6b    
Pard3  
Patl1  
Pax7  
Pbx3  
Pccb  
Pcdh9  
Pcsk5  
Pcx    
Pdgfrb    
Pdpn  
Pdx1    
Pex26  
Pfdn5  
Piezo1  
Pip5k1c  
Pitx2  
Pkd1    
Plpp3  
Pparg  
Pptc7  
Prdm12  
Prkab2    
Prkg1  
Psen1    
Pskh1  
Psph  
Ptk7    
Ptpn12  
Ptprs  
Pts  
Pttg1ip  
Rab23    
Rab34  
Rad1  
Rai14  
Ranbp1  
Rapsn    
Rcn3  
Rfx6  
Rfx7  
Ric8b    
Riiad1  
Rnf10  
Rnf38  
Robo4  
Rock1  
Rrp8  
Rsf1  
Runx3  
Ryr1    
Ryr2  
S100a6  
Satb2  
Sbk1  
Scamp5  
Scn4a  
Scnn1b  
Scrib  
Scx  
Serf2    
Shh  
Sirt1  
Slc16a3    
Slc17a6    
Slc22a17  
Slc24a4  
Slc35d1  
Slc39a8  
Slc52a2  
Slc6a2  
Slc6a5  
Slc7a8  
Smarcad1  
Smarcd2  
Smoc1    
Snx10  
Snx27  
Snx3    
Sort1    
Spi1  
Spop  
St14  
Stambp  
Stk38  
Stox2  
Strn3  
Sufu  
Svep1    
Synj1    
Synrg    
Tbr1  
Tbx4  
Tead1  
Tfeb  
Tgfb3  
Thra  
Tmem100  
Tmem115  
Tmem132a    
Tmem161b    
Tmtc3  
Tnni1  
Tnni2  
Tor1aip1    
Tra2a  
Trib1  
Trib2  
Trim59  
Trp73  
Tspan14  
Tulp3  
Tusc3  
Txlna  
Ube2b  
Ube2c  
Ublcp1  
Ubr2  
Ubr4  
Ubxn7  
Uhrf2  
Usf3  
Usp14  
Usp3  
Vps37d    
Vps4a  
Wfdc2    
Wnt1  
Wnt6  
Xbp1  
Xpot  
Ywhaz  
Zfp148  
Zfp260  
Zfp536  
Zscan21  
Zwilch  

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