MP:0020177 (abnormal IgG2b level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: abnormal IgG2b level

Definition

deviation from the normal levels of immunoglobulin class G2b level

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 8

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Clk1 Clk1^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased IgG2b level	IgG2b Immunoglobulin	ICS EuroPhenome	1.43×10^-08
Mysm1 Mysm1^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased IgG2b level	IgG2b Immunoglobulin	HMGU EuroPhenome	2.91×10^-08
Gper1 Gper1^tm1Dgen	HOM	Early adult	increased IgG2b level	IgG2b Immunoglobulin	HMGU EuroPhenome	2.78×10^-07
Plcg2 Plcg2^Ali14	HET	Early adult	increased IgG2b level	IgG2b Immunoglobulin	HMGU EuroPhenome	2.48×10^-06
Vmp1 Vmp1^{not yet available}	HET	Early adult	increased IgG2b level	IgG2b Immunoglobulin	HMGU EuroPhenome	4.97×10^-06
Bspry Bspry^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased IgG2b level	IgG2b Immunoglobulin	ICS EuroPhenome	7.70×10^-06
Rere Rere^Rere	HET	Early adult	increased IgG2b level	IgG2b Immunoglobulin	ICS EuroPhenome	2.47×10^-05
Crtc1 Crtc1^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased IgG2b level	IgG2b Immunoglobulin	ICS EuroPhenome	4.09×10^-05

Download data as: TSV XLS

Procedure
Immunoglobulin
Immunoglobulin concentration

7.48% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal IgG2b level (8/107)

2.86% females (3/105) 3.88% males (4/103)

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