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Phenotype: abnormal immature NK cell number

Definition
anomaly in the number of NK cells lacking expression of the maturation marker CD11b
Synonyms
abnormal immature natural killer cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal immature NK cell number

Total number of significant genotype-phenotype associations: 14

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive immature NK cell number Ly6C+ immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive immature NK cell number Ly6C+ immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult increased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 KMPC
IMPC		 8.51×10-26
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q3)
Immunophenotyping		 KMPC
IMPC		 1.40×10-11
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 HMGU
IMPC		 1.13×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM   Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 HMGU
IMPC		 8.60×10-06
Spink6
Spink6em1(IMPC)Ccpcz 		HOM   Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q3)
Immunophenotyping		 CCP-IMG
IMPC		 3.14×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Spleen Immunophenotyping

 Phenotype associations stats

2.36% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal immature NK cell number (10/424)

2.60% females (2/77) 1.32% males (1/76)

Select a parameter    



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