Phenotype: increased transitional stage T1 B cell number

Definition
greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative
Synonyms
increased transitional one stage B-cell number,  increased T1 stage B cell number,  increased transitional one stage B lymphocyte number,  increased transitional one stage B-lymphocyte number
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased transitional stage T1 B cell number

Total number of significant genotype-phenotype associations: 1

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Arhgap17
Arhgap17tm1b(EUCOMM)Wtsi
HOM   Early adult increased transitional stage T1 B cell number Transitional 1 B cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00

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 The way we measure

 Phenotype associations stats

0.27% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased transitional stage T1 B cell number (1/369)

0.00% females (0/2) 0.00% males (0/2)

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