Definition
any structural anomaly of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas
Synonyms
abnormal B-1 B-lymphocyte morphology,
abnormal B-1 B lymphocyte morphology,
abnormal B-1 B-cell morphology,
abnormal B1 cell morphology
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with abnormal B-1 B cell morphology
Total number of significant genotype-phenotype associations: 2
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Arhgap17 Arhgap17tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-1a cell number | B1a cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-1a cell number | B1B Cells Immunophenotyping |
HMGU IMPC |
3.10×10-05 |