Definition
any structural anomaly of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies
Synonyms
optic nerve dysplasia,
abnormal optic II nerve morphology,
abnormal CN-II morphology
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with abnormal optic nerve morphology
Total number of significant genotype-phenotype associations: 117
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Angptl4 Angptl4tm1b(EUCOMM)Hmgu |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
MRC Harwell IMPC |
0.00 | |
| Atg9b Atg9btm1b(KOMP)Mbp |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Bnip3 Bnip3em1(IMPC)Mbp |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Cacna1f Cacna1ftm1.1(KOMP)Vlcg |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Ccdc25 Ccdc25em1(IMPC)Mbp |
HET | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Crbn Crbntm1b(KOMP)Wtsi |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Dsc3 Dsc3tm1b(EUCOMM)Wtsi |
HET | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
MRC Harwell IMPC |
0.00 | |
| Gpx7 Gpx7tm1.1(KOMP)Vlcg |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Hcls1 Hcls1em1(IMPC)Ccpcz |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
CCP-IMG IMPC |
0.00 | |
| Krit1 Krit1tm1.1(KOMP)Vlcg |
HET | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Npas2 Npas2em1(IMPC)Mbp |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Phldb2 Phldb2em1(IMPC)H |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
MRC Harwell IMPC |
0.00 | |
| Prepl Preplem1(IMPC)H |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
MRC Harwell IMPC |
0.00 | |
| Rbm20 Rbm20em1(IMPC)Mbp |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Timp4 Timp4em1(IMPC)Mbp |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
UC Davis IMPC |
0.00 | |
| Tkfc Tkfcem1(IMPC)Ccpcz |
HOM | Early adult | absent optic nerve | Eye with optic nerve Gross Pathology and Tissue Collection |
CCP-IMG IMPC |
0.00 | |
| Tkfc Tkfcem1(IMPC)Ccpcz |
HOM | Early adult | abnormal optic nerve morphology | Eye with optic nerve Gross Pathology and Tissue Collection |
CCP-IMG IMPC |
0.00 | |
| Mettl23 Mettl23em1(IMPC)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
1.90×10-22 | |
| Pitx2 Pitx2tm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
6.14×10-17 | |
| Bmpr1b Bmpr1bem1(IMPC)Mbp |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
6.86×10-17 | |
| Pepd Pepdtm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
3.00×10-16 | |
| Nbas Nbastm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
7.69×10-16 | |
| Ppfibp2 Ppfibp2em1(IMPC)Tcp |
HOM | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
2.13×10-15 | |
| Sh3rf1 Sh3rf1em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
1.98×10-14 | |
| Dnmbp Dnmbpem1(IMPC)Mbp |
HOM | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
3.07×10-14 | |
| Bmp4 Bmp4tm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
8.54×10-14 | |
| Zfp503 Zfp503em1(IMPC)Mbp |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
2.40×10-13 | |
| Gdf6 Gdf6em1(IMPC)Ccpcz |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
CCP-IMG IMPC |
1.02×10-12 | |
| Col18a1 Col18a1tm1.1(KOMP)Vlcg |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
2.20×10-12 | |
| Foxd2 Foxd2em1(IMPC)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
9.47×10-11 | |
| Smoc1 Smoc1tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
3.28×10-10 | |
| Zbtb16 Zbtb16em1(IMPC)Mbp |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
2.60×10-09 | |
| Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
4.25×10-09 | |
| Sox2 Sox2em1(IMPC)Mbp |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
7.56×10-09 | |
| Tfap2b Tfap2btm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
8.46×10-09 | |
| Mettl5 Mettl5em1(IMPC)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
1.27×10-08 | |
| Stx5a Stx5atm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
2.06×10-08 | |
| Ipo8 Ipo8tm1.1(KOMP)Vlcg |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
7.89×10-08 | |
| Lpp Lpptm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
1.20×10-07 | |
| Ptp4a1 Ptp4a1em2(IMPC)Tcp |
HOM | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
1.23×10-07 | |
| Hmcn1 Hmcn1em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
1.40×10-07 | |
| Fhip2a Fhip2aem1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
1.49×10-07 | |
| Dpp3 Dpp3tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
2.94×10-07 | |
| Spin1 Spin1tm1.1(KOMP)Vlcg |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
4.20×10-07 | |
| Sesn1 Sesn1tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
5.29×10-07 | |
| Fam161a Fam161atm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
5.37×10-07 | |
| Rabgap1 Rabgap1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
6.41×10-07 | |
| Vps13b Vps13bem1(IMPC)Tcp |
HOM | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
1.98×10-06 | |
| Dbnl Dbnltm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
ICS IMPC |
2.08×10-06 | |
| Plekhm1 Plekhm1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
2.88×10-06 | |
| Stoml1 Stoml1em1(IMPC)Tcp |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
2.88×10-06 | |
| Ccdc34 Ccdc34em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
3.70×10-06 | |
| Nub1 Nub1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
CCP-IMG IMPC |
3.95×10-06 | |
| Rxfp2 Rxfp2tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
4.17×10-06 | |
| Ahsa1 Ahsa1em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
4.83×10-06 | |
| Nos1ap Nos1aptm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
6.17×10-06 | |
| Dnase1l2 Dnase1l2tm1.1(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
6.64×10-06 | |
| Foxd2 Foxd2em1(IMPC)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
7.33×10-06 | |
| Arl2bp Arl2bpem1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
7.70×10-06 | |
| Cdkn1b Cdkn1bem2(IMPC)H |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
8.03×10-06 | |
| Mapkapk2 Mapkapk2tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
8.03×10-06 | |
| Pard3 Pard3tm1b(KOMP)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
8.03×10-06 | |
| Ppfia2 Ppfia2tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
8.16×10-06 | |
| Cant1 Cant1tm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
9.90×10-06 | |
| Aif1 Aif1tm1.1(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
9.91×10-06 | |
| Dnm1l Dnm1ltm1b(KOMP)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
ICS IMPC |
1.34×10-05 | |
| Nxn Nxntm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MARC IMPC |
1.36×10-05 | |
| Cidec Cidectm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
1.40×10-05 | |
| Prdm5 Prdm5em1(IMPC)Tcp |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
1.71×10-05 | |
| Sra1 Sra1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
1.71×10-05 | |
| Sptlc3 Sptlc3em1(IMPC)Hmgu |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
1.93×10-05 | |
| Atp8b1 Atp8b1em1(IMPC)Tcp |
HOM | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
2.07×10-05 | |
| Rcc2 Rcc2tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
2.40×10-05 | |
| Egr1 Egr1tm1b(NCOM)Mfgc |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
TCP IMPC |
2.55×10-05 | |
| Ap1g1 Ap1g1tm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
2.84×10-05 | |
| Col1a2 Col1a2tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
MRC Harwell IMPC |
3.09×10-05 | |
| Cluh Cluhem1(IMPC)Ccpcz |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
CCP-IMG IMPC |
3.43×10-05 | |
| Ginm1 Ginm1tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
3.52×10-05 | |
| Slc7a11 Slc7a11tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
ICS IMPC |
3.71×10-05 | |
| Rab3gap2 Rab3gap2tm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
3.87×10-05 | |
| Syt8 Syt8em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
3.87×10-05 | |
| Pcif1 Pcif1em1(IMPC)Bay |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
4.20×10-05 | |
| Zfp329 Zfp329em1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
4.24×10-05 | |
| Ik Ikem2(IMPC)Kmpc |
HET | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
KMPC IMPC |
4.25×10-05 | |
| Gulo Guloem1(IMPC)Ccpcz |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
CCP-IMG IMPC |
4.31×10-05 | |
| Fbn2 Fbn2em1(IMPC)Rbrc |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
RBRC IMPC |
5.15×10-05 | |
| E2f3 E2f3tm1b(KOMP)Wtsi |
HET | Late adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
KMPC IMPC |
5.43×10-05 | |
| Egln3 Egln3tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
5.59×10-05 | |
| Zfp930 Zfp930tm1b(KOMP)Wtsi |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
BCM IMPC |
5.59×10-05 | |
| Lmna Lmnatm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
ICS IMPC |
6.38×10-05 | |
| Tbcel Tbcelem1(IMPC)J |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
JAX IMPC |
7.47×10-05 | |
| Tmeff2 Tmeff2em1(IMPC)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
8.77×10-05 | |
| Etfb Etfbem1(IMPC)Hmgu |
HET | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
HMGU IMPC |
9.70×10-05 | |
| Plxna4 Plxna4em1(IMPC)Mbp |
HOM | Early adult | abnormal optic disk morphology | Optic Disc Eye Morphology |
UC Davis IMPC |
9.82×10-05 |