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Gene: Rnase1 MGI:97919

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Gene Summary

Name:
ribonuclease, RNase A family, 1 (pancreatic)
Synonyms:
Rib-1,  Rib1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased prepulse inhibition Rnase1em5(IMPC)Tcp HOM   Early adult 3.63×10-06
abnormal skin morphology Rnase1em5(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Pathology and Tissue Collection

Images

8 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Histopathology

Images

3 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Immunophenotyping

Panel B FCS file(s)

6 Images

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Immunophenotyping

Panel A FCS file(s)

6 Images

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Human diseases caused by Rnase1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rnase1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Athrombia, Essential
Impaired platelet aggregation, Prolonged bleeding time, Impaired platelet adhesion OMIM:209050
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time OMIM:314560
Abdominal Obesity-Metabolic Syndrome 1
Abdominal obesity OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Abdominal obesity OMIM:605572
Glanzmann Thrombasthenia 2
Impaired epinephrine-induced platelet aggregation, Impaired clot retraction, Decreased platelet g... OMIM:619267
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity ORPHA:293964
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Tatsumi Factor Deficiency
Prolonged bleeding time OMIM:272650
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Von Willebrand Disease, Platelet-Type
Prolonged bleeding time OMIM:177820
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Hepatic Veno-Occlusive Disease
Jaundice, Increased body weight, Elevated circulating hepatic transaminase concentration ORPHA:890
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Bleeding Disorder, Platelet-Type, 18
Prolonged bleeding time, Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced ... OMIM:615888
Nephronophthisis 15
Obesity, Elevated circulating hepatic transaminase concentration OMIM:614845
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Glanzmann Thrombasthenia 1
Impaired epinephrine-induced platelet aggregation, Impaired clot retraction, Impaired platelet ag... OMIM:273800
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity OMIM:618406
Bleeding Disorder, Platelet-Type, 11
Impaired collagen-induced platelet aggregation, Prolonged bleeding time, Impaired ristocetin-indu... OMIM:614201
Obesity And Hypopigmentation
Obesity, Overgrowth OMIM:620195
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Bardet-Biedl Syndrome 21
Obesity, Overweight, Elevated circulating hepatic transaminase concentration OMIM:617406
Obesity Due To Melanocortin 4 Receptor Deficiency
Childhood-onset truncal obesity, Obesity ORPHA:71529
Bardet-Biedl Syndrome 22
Large for gestational age, Obesity OMIM:617119
Platelet Glycoprotein Iv Deficiency
Prolonged bleeding time OMIM:608404
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Platelet Disorder, Undefined
Impaired platelet aggregation, Prolonged bleeding time OMIM:173420
Wilson Disease
Jaundice, Elevated circulating hepatic transaminase concentration, Acute hepatitis, Increased bod... ORPHA:905
Blue Diaper Syndrome
Increased body weight, Elevated circulating hepatic transaminase concentration ORPHA:94086
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body weight, Increased body mass index OMIM:614450
Factor V Deficiency
Prolonged prothrombin time, Prolonged bleeding time OMIM:227400
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight ORPHA:589905
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Large for gestational age, Increased body weight, Elevated circulating hepatic transaminase conce... ORPHA:263455
Low Phospholipid-Associated Cholelithiasis
Intrahepatic cholestasis, Elevated circulating hepatic transaminase concentration, Obesity, Overw... ORPHA:69663
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Small for gestational age OMIM:274300
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Acth-Independent Macronodular Adrenal Hyperplasia 2
Abdominal obesity, Increased body weight OMIM:615954
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Large for gestational age, Elevated circulating alkaline phosphatase concentration, Elevated circ... OMIM:616026
Gray Platelet Syndrome
Impaired collagen-induced platelet aggregation, Prolonged bleeding time, Impaired thrombin-induce... OMIM:139090
Hellp Syndrome
Prolonged prothrombin time, Increased circulating lactate dehydrogenase concentration, Increased ... ORPHA:244242
Prothrombin Deficiency, Congenital
Prolonged prothrombin time, Prolonged bleeding time OMIM:613679
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Elevated circulating hepatic transaminase concentration, Abnormal circulating enzyme concentratio... ORPHA:264580
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Storage Pool Platelet Disease
Prolonged bleeding time OMIM:185050
Sotos Syndrome
Prolonged neonatal jaundice, Tall stature, Increased body weight, Overgrowth OMIM:117550
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Impaired platelet aggregation, Impaired ADP-induced platelet aggregation, Impaired collagen-induc... OMIM:601399
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Increased body weight, Elevated circulating hepatic transaminase concentration, Abnormal circulat... ORPHA:79240
Insulinoma
Increased body weight ORPHA:97279
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased body weight OMIM:615830
Adrenocortical Carcinoma
Increased body weight, Weight loss ORPHA:1501
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Increased body weight, Abdominal obesity ORPHA:398069
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Abdominal obesity, Increased body weight ORPHA:189427
Insulin-Resistance Syndrome Type B
Increased body weight, Decreased body weight, Abnormality of body weight, Weight loss ORPHA:2298
Cushing Disease
Abdominal obesity, Increased body weight, Truncal obesity ORPHA:96253
Cushing Syndrome Due To Ectopic Acth Secretion
Abdominal obesity, Increased body weight, Truncal obesity, Weight loss ORPHA:99889
Carney Complex
Abdominal obesity, Tall stature, Increased body weight ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rnase1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rnase1.

No publications found that use IMPC mice or data for Rnase1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Rnase1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Rnase1em5(IMPC)Tcp Indel Mice, Tissue
Rnase1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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