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Gene: Kcng2 MGI:3694646

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Gene Summary

Name:
potassium voltage-gated channel, subfamily G, member 2
Synonyms:
N/A

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased cardiac stroke volume Kcng2em1(IMPC)Bay HOM Early adult 2.44×10-06
increased heart weight Kcng2em1(IMPC)Bay HOM Early adult 1.80×10-05
decreased cardiac muscle contractility Kcng2em1(IMPC)Bay HOM Early adult 7.76×10-05
hyperactivity Kcng2em1(IMPC)Bay HOM   Early adult 6.18×10-05
decreased circulating serum albumin level Kcng2em1(IMPC)Bay HOM Early adult 4.74×10-09

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

10 Images

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Eye Morphology

VIP of left fundus

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Forepaw

10 Images

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Eye Morphology

VIP of right fundus

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Eye Morphology

VIP of left eye

14 Images

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Eye Morphology

VIP of right eye

14 Images

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

6 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Kcng2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kcng2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cardiomyopathy, Dilated, 1I
Congestive heart failure, Reduced left ventricular ejection fraction, Elevated circulating creati... OMIM:604765
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly, Hypoalbuminemia ORPHA:88643
Schizophrenia 15
Hyperactivity OMIM:613950
Hypermethioninemia With S-Adenosylhomocysteine Hydrolase Deficiency
Hypoalbuminemia, Increased circulating creatine kinase MM isoform, Cardiomyopathy, Hypermethionin... OMIM:613752
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Cholestasis, Progressive Familial Intrahepatic, 10
Hepatomegaly, Increased serum bile acid concentration, Increased total bilirubin, Splenomegaly, C... OMIM:619868
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Analbuminemia
Increased LDL cholesterol concentration, Elevated circulating transferrin concentration, Hypotens... OMIM:616000
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Bruxism, Aggressive behavior OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Bruxism, Aggressive behavior ORPHA:356996
Fibronectin Glomerulopathy
Hypoalbuminemia, Hypertension, Cerebral hemorrhage ORPHA:84090
Primary Membranoproliferative Glomerulonephritis
Hypoalbuminemia, Hypertension, Myocardial infarction ORPHA:54370
Nephrotic Syndrome, Type 2
Hypoalbuminemia, Hyperlipidemia OMIM:600995
Nephrotic Syndrome, Type 15
Hypoalbuminemia OMIM:617609
Congenital Enterocyte Heparan Sulfate Deficiency
Hypoalbuminemia, Hematochezia, Abnormal circulating polysaccharide concentration, Abnormal circul... ORPHA:103910
Erythroderma, Lethal Congenital
Hypoalbuminemia OMIM:227090
Focal Segmental Glomerulosclerosis 1
Hypoalbuminemia, Hypertension, Hyperlipidemia OMIM:603278
Triokinase And Fmn Cyclase Deficiency Syndrome
Hypoalbuminemia, Dilated cardiomyopathy, Hepatomegaly, Reduced systolic function OMIM:618805
Diarrhea 7, Protein-Losing Enteropathy Type
Hypoalbuminemia, Hypercholesterolemia, Hyperlipidemia OMIM:615863
Smith-Magenis syndrome
Hyperactivity, Self-mutilation, Motor stereotypy DECIPHER:8
Diarrhea 13
Hypoalbuminemia OMIM:620357
Intellectual Developmental Disorder, X-Linked 109
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... OMIM:309548
Fraxe Intellectual Disability
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... ORPHA:100973
Immunodeficiency 115 With Autoinflammation
Elevated circulating C-reactive protein concentration, Elevated haptoglobin level, Splenomegaly, ... OMIM:620632
Nephrotic Syndrome, Type 9
Hypoalbuminemia OMIM:615573
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity, Motor stereotypy OMIM:300271
Focal Segmental Glomerulosclerosis 6
Hypoalbuminemia OMIM:614131
Autoinflammation With Infantile Enterocolitis
Elevated circulating C-reactive protein concentration, Hypoalbuminemia, Splenomegaly, Diffuse alv... OMIM:616050
8p23.1 deletion syndrome
Hyperactivity, Atrial septal defect, Atrioventricular canal defect, Abnormal heart morphology DECIPHER:39
Alg1-Cdg
Hypoalbuminemia, Abnormal heart morphology, Cardiomyopathy ORPHA:79327
Lodder-Merla Syndrome, Type 2, With Developmental Delay And With Or Without Cardiac Arrhythmia
Sick sinus syndrome, Bradycardia, Hyperactivity, Patent foramen ovale, Attention deficit hyperact... OMIM:617182
Coenzyme Q10 Deficiency, Primary, 3
Hypoalbuminemia OMIM:614652
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Hypoalbuminemia, Hypercholesterolemia ORPHA:94124
Cardiomyopathy, Familial Hypertrophic, 27
Congestive heart failure, Ventricular septal hypertrophy, Prolonged QT interval, Concentric hyper... OMIM:618052
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
Hypoalbuminemia, Hypercholesterolemia OMIM:607250
Galloway-Mowat Syndrome 6
Hypoalbuminemia, Motor stereotypy, Paroxysmal bursts of laughter OMIM:618347
Tropical Endomyocardial Fibrosis
Left atrial enlargement, P pulmonale, Abnormal ST segment, Splenomegaly, Prolonged QRS complex, C... ORPHA:75565
Cirrhotic Cardiomyopathy
Left atrial enlargement, Prolonged QT interval, Third heart sound, Arrhythmia, Left ventricular h... ORPHA:57777
Nephrotic Syndrome, Type 7
Hypoalbuminemia OMIM:615008
Immunodeficiency 27A
Anorexia, Hypoalbuminemia, Hepatosplenomegaly, Splenomegaly OMIM:209950
Chylomicron Retention Disease
Hypoalbuminemia, Decreased LDL cholesterol concentration, Hypocholesterolemia, Hypotriglyceridemia OMIM:246700
Citrullinemia Type Ii
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hepatomegaly, Elevated plasma citr... ORPHA:247585
Mpi-Cdg
Hypoalbuminemia, Gastrointestinal hemorrhage, Hepatomegaly, Portal hypertension ORPHA:79319
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity, Self-injurious behavior, Aggressive behavior OMIM:619031
Al Amyloidosis
Gastrointestinal hemorrhage, Hepatomegaly, Increased circulating NT-proBNP concentration, Abnorma... ORPHA:85443
Attrv122I Amyloidosis
Abnormal atrioventricular conduction, Congestive heart failure, Increased circulating NT-proBNP c... ORPHA:85451
Congenital Lethal Erythroderma
Hypoalbuminemia ORPHA:1954
Eosinophilic Gastroenteritis
Hypoalbuminemia, Hematochezia, Dysphagia, Elevated circulating C-reactive protein concentration ORPHA:2070
Ménétrier Disease
Anorexia, Hypoalbuminemia, Gastrointestinal hemorrhage, Hypoproteinemia ORPHA:2494
Nephrotic Syndrome, Type 11
Hypoalbuminemia, Dilated cardiomyopathy, Ventricular septal defect, Hypercholesterolemia OMIM:616730
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Hypertension, Pulmonary arterial hypertension, Hypoalbuminemia, Overriding aorta, Ventricular sep... OMIM:617021
Lymphoproliferative Syndrome, X-Linked, 1
Hepatomegaly, Elevated circulating C-reactive protein concentration, Vasculitis, Splenomegaly, Hy... OMIM:308240
Leishmaniasis
Anorexia, Hypoalbuminemia, Hepatomegaly, Splenomegaly ORPHA:507
Hyperprolinemia, Type I
Hyperactivity, Hyperprolinemia, Motor stereotypy, Aggressive behavior OMIM:239500
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Congestive heart failure, Hepatomegaly, Portal hypertension, Hepatosplenomegaly, Abnormal cardiom... ORPHA:367
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:301008
Glycine Encephalopathy 1
Hyperactivity, Impulsivity, Restlessness, Hyperglycinemia, Aggressive behavior OMIM:605899
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hypertriglyceridemia, Abnormal circulating lipid concentration, Gastrointestinal hemorrhage, Decr... ORPHA:247598
Galloway-Mowat Syndrome 8
Hypoalbuminemia OMIM:618349
Nephrotic Syndrome, Type 3
Hypoalbuminemia OMIM:610725
Mitochondrial Dna Depletion Syndrome 16 (Hepatic Type)
Hyperkalemia, Hepatomegaly, Increased total bilirubin, Conjugated hyperbilirubinemia, Hypoalbumin... OMIM:618528
Fixed Subaortic Stenosis
Paroxysmal atrial fibrillation, Congestive heart failure, Bicuspid aortic valve, Atrioventricular... ORPHA:3092
Rajab Interstitial Lung Disease With Brain Calcifications 2
Hypertriglyceridemia, Hypoalbuminemia, Hepatosplenomegaly OMIM:619013
Nephrotic Syndrome, Type 6
Hypoalbuminemia OMIM:614196
Hemophagocytic Lymphohistiocytosis, Familial, 1
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hepatomegaly, Increased LDL choles... OMIM:267700
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Hepatomegaly, Hypoproteinemia, Budd-Chiari syndrome, Hypoalbuminemia, Pulmonary embolism OMIM:226300
Congenital Analbuminemia
Hypoproteinemia, Hyperlipidemia, Low pulse pressure, Hypoalbuminemia, Increased alpha-globulin, H... ORPHA:86816
Coronary Arterial Fistula
Congestive heart failure, Bicuspid aortic valve, Atrial septal defect, Cardiomegaly, Tachycardia,... ORPHA:2041
Alg6-Cdg
Hypoalbuminemia, Decreased LDL cholesterol concentration ORPHA:79320
S-Adenosylhomocysteine Hydrolase Deficiency
Abnormal circulating homocysteine concentration, Abnormal circulating methionine concentration, H... ORPHA:88618
Congenital Disorder Of Glycosylation, Type Il
Hepatomegaly, Hypocholesterolemia, Pericardial effusion, Splenomegaly, Hypoalbuminemia, Atrial se... OMIM:608776
Idiopathic Steroid-Resistant Nephrotic Syndrome
Hypertriglyceridemia, Abnormal circulating lipid concentration, Hypoalbuminemia, Pulmonary emboli... ORPHA:567548
Spinocerebellar Ataxia With Axonal Neuropathy Type 2
Elevated circulating creatine kinase concentration, Dysphagia, Elevated circulating alpha-fetopro... ORPHA:64753
Arterial Calcification, Generalized, Of Infancy, 2
Congestive heart failure, Hypophosphatemic rickets, Reduced left ventricular ejection fraction, S... OMIM:614473
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Hypoalbuminemia, Hypercholesterolemia, Elevated circulating creatine kinase concentration OMIM:208920
Immunodeficiency 43
Hypoalbuminemia, Decreased circulating beta-2-microglobulin level, Hypoproteinemia OMIM:241600
Congenital Disorder Of Glycosylation, Type Ih
Elevated circulating creatinine concentration, Perimembranous ventricular septal defect, Hepatome... OMIM:608104
Isolated Right Ventricular Hypoplasia
Abnormal atrioventricular conduction, Congestive heart failure, Bidirectional shunt, Muscular ven... ORPHA:439
Ataxia-Oculomotor Apraxia 4
Hypoalbuminemia, Hypercholesterolemia, Elevated circulating alpha-fetoprotein concentration OMIM:616267
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Hyperbilirubinemia, Portal hypertension, Splenomegaly, Hypoalbuminemia ORPHA:64743
Congenital Enterovirus Infection
Myocarditis, Cardiomyopathy, Hypotension, Pericardial effusion, Hyperammonemia, Hypoalbuminemia ORPHA:292
Immunodeficiency 32B
Hypoalbuminemia, Hepatomegaly, Splenomegaly OMIM:226990
Aicardi-Goutieres Syndrome 9
Hepatomegaly, Increased blood pressure, Hypertension, Portal hypertension, Pericarditis, Pericard... OMIM:619487
Cardiomyopathy, Familial Hypertrophic, 4
Congestive heart failure, Ventricular septal hypertrophy, Muscular ventricular septal defect, Lef... OMIM:115197
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Hepatomegaly, Elevated circulating creatine kinase concentration, Hyperammonemia, Cardiomegaly, V... OMIM:600649
Macrophage Activation Syndrome
Hypertriglyceridemia, Hepatomegaly, Elevated circulating C-reactive protein concentration, Spleno... ORPHA:158061
Nephrotic Syndrome, Type 1
Hypoalbuminemia, Hypoproteinemia, Hyperlipidemia OMIM:256300
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Increased serum bile acid concentration, Hypoalbuminemia, Decreased circulating ceruloplasmin con... OMIM:242150
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hypertriglyceridemia, Hepatomegaly, Hypoproteinemia, Increased total bilirubin, Hyponatremia, Hep... OMIM:603553
Congenitally Uncorrected Transposition Of The Great Arteries
Abnormal QRS complex, Congestive heart failure, Abnormal ventriculoarterial connection, Hepatomeg... ORPHA:860
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Frequent temper tantrums, Impulsivity, Pulmonic stenosis, Facial telangiectasia, M... OMIM:620141
Amoebiasis Due To Entamoeba Histolytica
Abnormal pericardium morphology, Congestive heart failure, Hypoalbuminemia, Constrictive pericard... ORPHA:67
Avian Influenza
Congestive heart failure, Hypoalbuminemia, Elevated circulating creatine kinase concentration, El... ORPHA:454836
Intellectual Developmental Disorder, Autosomal Dominant 67
Hyperactivity, Attention deficit hyperactivity disorder, Compulsive behaviors, Motor tics OMIM:619927
Mucopolysaccharidosis-Plus Syndrome
Congestive heart failure, Enlarged kidney, Hepatomegaly, Hypertrophic cardiomyopathy, Splenomegal... OMIM:617303
Generalized Pustular Psoriasis
Congestive heart failure, Elevated circulating C-reactive protein concentration, Hypocalcemia, Hy... ORPHA:247353
Familial Atrial Myxoma
Congestive heart failure, Bacterial endocarditis, Cardiac myxoma, Tricuspid regurgitation, Pulmon... ORPHA:615
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines OMIM:301076
Wolcott-Rallison Syndrome
Hepatomegaly, Hyperbilirubinemia, Hyperammonemia, Hyponatremia, Double outlet right ventricle, Hy... ORPHA:1667
Liver Failure, Infantile, Transient
Hypoalbuminemia, Hepatomegaly, Hyperbilirubinemia OMIM:613070
Refractory Celiac Disease
Hypocalcemia, Hypoproteinemia, Hypomagnesemia, Hypophosphatemia, Hypoalbuminemia ORPHA:398063
Refractory Anemia With Excess Blasts
Palpitations, Abnormal circulating albumin concentration, Retinal hemorrhage, Abnormal circulatin... ORPHA:86839
Nephrotic Syndrome, Type 8
Hypoalbuminemia OMIM:615244
Diarrhea 10, Protein-Losing Enteropathy Type
Hypertriglyceridemia, Hypocalcemia, Pericardial effusion, Hyponatremia, Hematochezia, Hypomagnese... OMIM:618183
Attrv30M Amyloidosis
Atrioventricular block, Cardiomyopathy, Cardiomegaly, Arrhythmia ORPHA:85447
Bacterial Toxic-Shock Syndrome
Myocarditis, Capillary leak, Hypocalcemia, Hypotension, Elevated circulating creatine kinase conc... ORPHA:36234
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Pulmonic stenosis, Hypernatremia, Hypoalbuminemia, Multiple muscular ventricular septal defects OMIM:615508
Congenital Disorder Of Glycosylation, Type Ib
Hypoalbuminemia, Hepatomegaly OMIM:602579
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hepatomegaly, Hyperbilirubinemia, Portal hypertension, Splenomegaly, Elevated circulating alpha-f... OMIM:251880
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Decreased circulating carnitine concentration, Decreased serum zinc, Decreased circulating iron c... ORPHA:89842
Familial Hemophagocytic Lymphohistiocytosis
Hypertriglyceridemia, Hepatomegaly, Splenomegaly, Hypoalbuminemia, Increased circulating ferritin... ORPHA:540
Primary Intestinal Lymphangiectasia
Hypocalcemia, Hypoproteinemia, Pericardial effusion, Hypomagnesemia, Hypoalbuminemia ORPHA:90362
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Congestive heart failure, Enlarged kidney, Patent foramen ovale, Tricuspid regurgitation, Pulmona... ORPHA:505248
Complete Atrioventricular Septal Defect
Third heart sound, Left-to-right shunt, Cardiomegaly, Pulmonary venous hypertension, Abnormal car... ORPHA:1329
Danon Disease
Congestive heart failure, Wolff-Parkinson-White syndrome, Cardiomegaly, Atrial arrhythmia, Myocar... OMIM:300257
Intellectual Developmental Disorder, X-Linked, Syndromic 32
Cardiomegaly, Congestive heart failure OMIM:300886
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Inappropriate behavior, Nail-biting, Hyperactivity, Attention deficit hyperactivity disorder, Sel... OMIM:619827
Combined Oxidative Phosphorylation Deficiency 37
Hypoalbuminemia, Hyperalaninemia, Hypertrophic cardiomyopathy OMIM:618329
Abetalipoproteinemia
Congestive heart failure, Decreased HDL cholesterol concentration, Hepatomegaly, Hypotriglyceride... ORPHA:14
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Pericardial lymphangiectasia, Hyperactivity, Pericardial effusion, Hypoalbuminemia, Atrial septal... OMIM:235510
Reni Syndrome
Hypertriglyceridemia, Hypoalbuminemia OMIM:617575
Mucopolysaccharidosis, Type Iiib
Hepatomegaly, Hyperactivity, Asymmetric septal hypertrophy, Splenomegaly, Cardiomegaly, Aggressiv... OMIM:252920
Phoar2-Enteropathy Syndrome
Hypoalbuminemia OMIM:614441
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Compulsive behaviors, Impulsivity, Abnormal eating behavior, Aggressive behavior ORPHA:101039
Genetic Steroid-Resistant Nephrotic Syndrome
Hypoalbuminemia ORPHA:656
Trichohepatoenteric Syndrome 1
Hepatomegaly, Abnormality of iron homeostasis, Aortic regurgitation, Hypergalactosemia, Pulmonic ... OMIM:222470
Congenital Disorder Of Glycosylation, Type Ia
Hepatomegaly, Cardiomyopathy, Pericardial effusion, Pericarditis, Hypoalbuminemia, Hypocholestero... OMIM:212065
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Congestive heart failure, Hypertyrosinemia, Hyperbilirubinemia, Conjugated hyperbilirubinemia, Hy... OMIM:617156
Marburg Hemorrhagic Fever
Anorexia, Shock, Hypokalemia, Bradycardia, Capillary leak, Hyperamylasemia, Hypotension, Hypovole... ORPHA:99826
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Recurrent hand flapping, Pulmonic stenosis, Motor stereotypy, Heart murmur, Attent... OMIM:617600
Chronic Bilirubin Encephalopathy
Hypernatremia, Hypoalbuminemia, Neonatal hyperbilirubinemia ORPHA:529808
Acute Bilirubin Encephalopathy
Hypernatremia, Hypoalbuminemia, Neonatal hyperbilirubinemia ORPHA:529799
Juvenile Polyposis Syndrome
Hypoalbuminemia, Hematochezia, Hypokalemia OMIM:174900
Juvenile Polyposis Of Infancy
Gastrointestinal hemorrhage, Melena, Abnormal heart morphology, Hematochezia, Intestinal bleeding... ORPHA:79076
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Hypoalbuminemia, Pulmonary embolism, Hypertension, Hyperlipidemia ORPHA:567546
Secondary Intestinal Lymphangiectasia
Decreased circulating prealbumin concentration, Right ventricular failure, Intestinal bleeding, R... ORPHA:90363
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Intraventricular hemorrhage, Hypoalbuminemia, Elevated circulating creatine kinase concentration OMIM:619055
Hemochromatosis, Type 1
Congestive heart failure, Hepatomegaly, Cardiomyopathy, Increased circulating iron concentration,... OMIM:235200
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy
Hyperammonemia, Hypoalbuminemia, Conjugated hyperbilirubinemia, Decreased serum zinc OMIM:617093
Primary Biliary Cholangitis
Abnormal circulating lipid concentration, Hepatomegaly, Orthostatic hypotension, Portal hypertens... ORPHA:186
Familial Idiopathic Dilatation Of The Right Atrium
Paroxysmal atrial fibrillation, Hepatomegaly, Cardiomegaly, Reduced left ventricular ejection fra... ORPHA:1677
Xfe Progeroid Syndrome
Hypoalbuminemia, Hypertension OMIM:610965
Alg12-Cdg
Muscular ventricular septal defect, Patent foramen ovale, Hyponatremia, Hypoalbuminemia, Hypochol... ORPHA:79324
Naxos Disease
Congestive heart failure, Right ventricular cardiomyopathy, Cardiomegaly, Paroxysmal ventricular ... OMIM:601214
Galloway-Mowat Syndrome 3
Hypoalbuminemia, Hypertension OMIM:617729
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Hypocalcemia, Decreased circulating prealbumin concentration, Hypomagnesemia, Splenomegaly, Abnor... ORPHA:37042
Kawasaki Disease
Myocarditis, Congestive heart failure, Elevated circulating C-reactive protein concentration, Vas... ORPHA:2331
Congenital Tricuspid Valve Dysplasia
Tricuspid valve prolapse, Hepatomegaly, Abnormal tricuspid valve annulus morphology, Patent foram... ORPHA:555874
Aorta Coarctation
Congestive heart failure, Perimembranous ventricular septal defect, Cardiomegaly, Aortic valve at... ORPHA:1457
Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure
Hypoalbuminemia, Dysphagia OMIM:254900
Interatrial Communication
Congestive heart failure, Atrial septal defect, Atrial flutter, Sinus venosus atrial septal defec... ORPHA:1478
Primary Sclerosing Cholangitis
Congestive heart failure, Hepatomegaly, Spider hemangioma, Portal hypertension, Hepatosplenomegal... ORPHA:171
Smith-Lemli-Opitz Syndrome
Hepatomegaly, Hyperactivity, Hypertension, Hypertrophic cardiomyopathy, Hypocholesterolemia, Elev... OMIM:270400
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Hyperactivity, Hypertension, Recurrent hand flapping, Motor stereotypy,... ORPHA:449291
Insulin-Resistance Syndrome Type B
Abnormal circulating lipid concentration, Hypotriglyceridemia, Enlarged polycystic ovaries, Abnor... ORPHA:2298
Wilson Disease
Hepatomegaly, Decreased circulating ceruloplasmin concentration, Hypouricemia, Hyperbilirubinemia... OMIM:277900
Biliary, Renal, Neurologic, And Skeletal Syndrome
Inlet ventricular septal defect, Left-to-right shunt, Splenomegaly, Elevated circulating creatini... OMIM:619534
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Hypokalemia, Hypomagnesemia, Self-biting OMIM:618314
Galloway-Mowat Syndrome 1
Hypoalbuminemia OMIM:251300
Glycogen Storage Disease Of Heart, Lethal Congenital
Congestive heart failure, Enlarged kidney, Bradycardia, ST segment elevation, Cardiomyopathy, Hyp... OMIM:261740
Immunodeficiency 82 With Systemic Inflammation
Anorexia, Elevated circulating C-reactive protein concentration, Vasculitis in the skin, Hypernat... OMIM:619381
Arterial Calcification, Generalized, Of Infancy, 1
Congestive heart failure, Hypophosphatemic rickets, Hypertension, Cardiomegaly, Dilated cardiomyo... OMIM:208000
Rajab Interstitial Lung Disease With Brain Calcifications 1
Hypocalcemia, Hypoalbuminemia, Portal hypertension, Unconjugated hyperbilirubinemia OMIM:613658
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Hypoalbuminemia ORPHA:79396
Histidinemia
Hyperactivity, Hyperhistidinemia ORPHA:2157
Hyperthyroidism, Nonautoimmune
Hyperactivity, Increased circulating thyroglobulin concentration, Tachycardia OMIM:609152
Double Outlet Left Ventricle
Pulmonary valve atresia, Double outlet left ventricle, Tricuspid atresia, Abnormal right ventricu... ORPHA:3427
Absence Of The Pulmonary Artery
Congestive heart failure, Atrial flutter, Cardiomegaly, Reduced left ventricular ejection fractio... ORPHA:980
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome
Hypoalbuminemia OMIM:614748
Pmm2-Cdg
Angina pectoris, Reduced thyroxin-binding globulin, Hypertrophic cardiomyopathy, Pericarditis, Pe... ORPHA:79318
Congenital Total Pulmonary Venous Return Anomaly
Cardiomegaly, Mixed total anomalous pulmonary venous connection, Transposition of the great arter... ORPHA:99125

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kcng2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kcng2.

No publications found that use IMPC mice or data for Kcng2.

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MGI Allele Allele Type Produced
Kcng2em1(IMPC)Bay Exon Deletion Mice
Kcng2tm466063(Ifitm2_intron_L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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