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Gene: Lrit3 MGI:2685267

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Gene Summary

Name:
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms:
LOC242235

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal behavior Lrit3em1(IMPC)Mbp HOM   Early adult 5.87×10-05
increased exploration in new environment Lrit3em1(IMPC)Mbp HOM Early adult 9.25×10-12
decreased anxiety-related response Lrit3em1(IMPC)Mbp HOM   Early adult 6.74×10-06
abnormal epididymis morphology Lrit3em1(IMPC)Mbp HOM Early adult 0.00
hyperactivity Lrit3em1(IMPC)Mbp HOM Early adult 4.26×10-07
decreased thigmotaxis Lrit3em1(IMPC)Mbp HOM   Early adult 9.28×10-06
enlarged epididymis Lrit3em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Lrit3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lrit3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Stationary Night Blindness
Retinal thinning, Color vision defect, Hypermetropia, Congenital stationary night blindness with ... ORPHA:215
Night Blindness, Congenital Stationary, Type 1F
Congenital stationary night blindness, High myopia, Reduced visual acuity, Retinal perforation, N... OMIM:615058

The table below shows human diseases predicted to be associated to Lrit3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder, Depression OMIM:613003
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity, Short attention span DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity, Short attention span OMIM:608443
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Bruxism, Aggressive behavior OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Bruxism, Aggressive behavior ORPHA:356996
Pandas
Anorexia, Obsessive-compulsive trait, Irritability, Abnormal fear-induced behavior, Depression, E... ORPHA:66624
Choroideremia
Constriction of peripheral visual field, Granular macular appearance, Bone spicule pigmentation o... OMIM:303100
Stargardt Disease
Retinal thinning, Color vision defect, Central scotoma, Macular degeneration, Photopsia, Abnormal... ORPHA:827
Smith-Magenis syndrome
Hyperactivity, Self-mutilation, Motor stereotypy DECIPHER:8
Retinitis Pigmentosa 73
Constriction of peripheral visual field, Color vision defect, Bone spicule pigmentation of the re... OMIM:616544
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity, Motor stereotypy OMIM:300271
Familial Drusen
Granular macular appearance, Macular dystrophy, Visual loss, Peripapillary chorioretinal atrophy,... ORPHA:75376
Intellectual Developmental Disorder, X-Linked 109
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... OMIM:309548
Fraxe Intellectual Disability
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... ORPHA:100973
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Pseudobulbar paralysis, Abnormal fear-induced behavior, Delirium, Aggressive behavior ORPHA:208441
Megalencephalic Leukoencephalopathy With Subcortical Cysts 4, Remitting
Hyperactivity, Dysphagia, Impulsivity OMIM:620448
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:301008
Morm Syndrome
Hyperactivity, Micropenis, Aggressive behavior ORPHA:75858
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Irritability, Abnormal fear-induced behavior, Hyperactivity, Abnormal aggressive, impul... ORPHA:3077
Glycine Encephalopathy 1
Irritability, Hyperactivity, Impulsivity, Restlessness, Aggressive behavior OMIM:605899
8p23.1 deletion syndrome
Hyperactivity, Cryptorchidism DECIPHER:39
Hartnup Disorder
Hyperactivity, Attention deficit hyperactivity disorder, Emotional lability OMIM:234500
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity, Self-injurious behavior, Aggressive behavior OMIM:619031
Developmental And Epileptic Encephalopathy 104
Hyperactivity, Self-injurious behavior, Agitation OMIM:619970
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:617113
Lennox-Gastaut Syndrome
Hyperactivity, Irritability, Mental deterioration, Aggressive behavior ORPHA:2382
Intellectual Developmental Disorder, Autosomal Dominant 67
Hyperactivity, Attention deficit hyperactivity disorder, Compulsive behaviors, Motor tics OMIM:619927
Congenital Stationary Night Blindness
Retinal thinning, Color vision defect, Hypermetropia, Congenital stationary night blindness with ... ORPHA:215
Coffin-Siris Syndrome 8
Hyperactivity, Self-injurious behavior, Cryptorchidism, Aggressive behavior OMIM:618362
Hyperprolinemia, Type I
Hyperactivity, Motor stereotypy, Aggressive behavior OMIM:239500
Landau-Kleffner Syndrome
Memory impairment, Hyperactivity, Depression, Emotional lability, Short attention span, Impulsivi... ORPHA:98818
Intellectual Developmental Disorder, X-Linked 111
Hyperactivity, Phonic tics, Compulsive behaviors, Aggressive behavior OMIM:301107
Phenylketonuria
Irritability, Hyperactivity, Depression, Compulsive behaviors, Attention deficit hyperactivity di... OMIM:261600
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines OMIM:301076
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Inappropriate behavior, Nail-biting, Memory impairment, Hyperactivity, Attention deficit hyperact... OMIM:619827
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Recurrent hand flapping, Diminished ability to concentrate, Self-mutilation, Aggre... OMIM:615516
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Hypospadias, Abnormal testis morphology, Vaginal neoplasm, Abnormality ... ORPHA:1916
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity, Depression, Compulsive behaviors, Self-injurious behavior, Aggressive behavior OMIM:619467
Lodder-Merla Syndrome, Type 2, With Developmental Delay And With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity, Macroorchidism, Impulsivity OMIM:300143
Fragile X Syndrome
Congenital macroorchidism, Hyperactivity, Macroorchidism, postpubertal, Recurrent hand flapping, ... OMIM:300624
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Compulsive behaviors, Impulsivity, Abnormal eating behavior, Aggressive behavior ORPHA:101039
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Macroorchidism, Aggressive behavior ORPHA:85327
Juvenile Huntington Disease
Hyperactivity, Irritability, Depression, Dementia ORPHA:248111
2Q23.1 Microdeletion Syndrome
Hypoplasia of penis, Hyperactivity, Polyphagia, Motor stereotypy, Self-injurious behavior, Crypto... ORPHA:228402
47,Xyy Syndrome
Hypospadias, Azoospermia, Hyperactivity, Oligozoospermia, Impulsivity, Varicocele, Attention defi... ORPHA:8
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Hyperactivity, Motor stereotypy, Self-injurious behavior, Bruxism, Paroxysmal bursts of laughter OMIM:618718
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Frequent temper tantrums, Impulsivity, Motor stereotypy, Attention deficit hyperac... OMIM:620141
Inverted Duplicated Chromosome 15 Syndrome
Gonadal dysgenesis, Hyperactivity, Precocious puberty, Motor stereotypy, Hypogonadism, Cryptorchi... ORPHA:3306
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Hyperactivity, Depression, Short attention span, Dysphoria, Motor stereotypy, Attention deficit h... OMIM:620242
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Attention deficit hyperactivity disorder, Aggressive behavior OMIM:301013
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Abnormal fear-induced behavior, Cognitive impairment ORPHA:309246
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Low frustration tolerance, Microphallus, Motor stereotypy, Small scrotum, Cryptorc... OMIM:300486
Cntnap2-Related Developmental And Epileptic Encephalopathy
Abnormal temper tantrums, Hyperactivity, Low frustration tolerance, Stereotypical hand wringing, ... ORPHA:163681
Graves Disease
Hyperactivity, Irritability, Polyphagia OMIM:275000
Porphyria Due To Ala Dehydratase Deficiency
Agitation, Abnormal fear-induced behavior, Depression, Confusion, Restlessness, Delirium ORPHA:100924
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Irritability, Hyperactivity, Depression, Recurrent hand flapping, Short... ORPHA:449291
Fg Syndrome 3
Hyperactivity, Cryptorchidism OMIM:300406
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Progressive language deterioration, Motor stereotypy, Attention deficit hyperactiv... OMIM:610042
X-Linked Adrenoleukodystrophy
Hyperactivity, Cognitive impairment, Disinhibition, Dementia, Attention deficit hyperactivity dis... ORPHA:43
Night Blindness, Congenital Stationary, Type 1F
Congenital stationary night blindness, High myopia, Reduced visual acuity, Retinal perforation, N... OMIM:615058
Neurodegeneration With Brain Iron Accumulation 2B
Hyperactivity, Emotional lability, Short attention span, Impulsivity, Dysphagia, Mental deteriora... OMIM:610217
Floating-Harbor Syndrome
Abnormal temper tantrums, Hypospadias, Compulsive behaviors, Impulsivity, Short attention span, E... ORPHA:2044
Pituitary Adenoma 4, Acth-Secreting
Emotional lability, Abnormal fear-induced behavior OMIM:219090
Microcephaly 29, Primary, Autosomal Recessive
Hyperactivity, Emotional lability OMIM:620047
Histidinemia
Hyperactivity ORPHA:2157
Von Hippel-Lindau Syndrome
Epididymal cyst, Papillary cystadenoma of the epididymis OMIM:193300
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353281
Renal Cysts And Diabetes Syndrome
Hypospadias, Bicornuate uterus, Atretic vas deferens, Epididymal cyst, Hypoplasia of the uterus OMIM:137920
Floating-Harbor Syndrome
Hypospadias, Glandular hypospadias, Varicocele, Epididymal cyst, Cryptorchidism, Aggressive behavior OMIM:136140
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353277
Von Hippel-Lindau Disease
Epididymal cyst, Papillary cystadenoma of the epididymis ORPHA:892

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrit3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrit3.

No publications found that use IMPC mice or data for Lrit3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lrit3em1(IMPC)Mbp Exon Deletion Mice, Tissue

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