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Gene: Adgrg7 MGI:2441732

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Gene Summary

Name:
adhesion G protein-coupled receptor G7
Synonyms:
Gpr128,  9130020O16Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total retina thickness Adgrg7tm1b(EUCOMM)Hmgu HOM Early adult 1.30×10-08
decreased heart weight Adgrg7tm1b(EUCOMM)Hmgu HOM Early adult 9.83×10-05
abnormal retina outer nuclear layer morphology Adgrg7tm1b(EUCOMM)Hmgu HOM   Early adult 5.28×10-08
abnormal eye anterior chamber depth Adgrg7tm1b(EUCOMM)Hmgu HOM Early adult 1.11×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Gall bladder  Wholemount images heterozygote 100% (1 of 1)
Large intestine  Wholemount images heterozygote 100% (1 of 1)
Testis  Wholemount images heterozygote 100% (1 of 1)
Adrenal gland N/A heterozygote 0.0% (0 of 1)
Aorta N/A heterozygote 0.0% (0 of 1)
Bone N/A heterozygote 0.0% (0 of 1)
Brain N/A heterozygote 0.0% (0 of 1)
Brainstem N/A heterozygote 0.0% (0 of 1)
Brown adipose tissue N/A heterozygote 0.0% (0 of 1)
Cartilage tissue N/A heterozygote 0.0% (0 of 1)
Cerebellum N/A heterozygote 0.0% (0 of 1)
Cerebral cortex N/A heterozygote 0.0% (0 of 1)
Esophagus N/A heterozygote 0.0% (0 of 1)
Eye N/A heterozygote Not available
Heart N/A heterozygote 0.0% (0 of 1)
Hippocampus N/A heterozygote 0.0% (0 of 1)
Hypothalamus N/A heterozygote 0.0% (0 of 1)
Kidney N/A heterozygote 0.0% (0 of 1)
Liver N/A heterozygote 0.0% (0 of 1)
Lower urinary tract N/A heterozygote 0.0% (0 of 1)
Lung N/A heterozygote 0.0% (0 of 1)
Lymph node N/A heterozygote 0.0% (0 of 1)
Mammary gland N/A heterozygote Not available
Mesenteric lymph node N/A heterozygote 0.0% (0 of 1)
Olfactory lobe N/A heterozygote 0.0% (0 of 1)
Oral epithelium N/A heterozygote 0.0% (0 of 1)
Ovary N/A heterozygote Not available
Oviduct N/A heterozygote Not available
Pancreas N/A heterozygote 0.0% (0 of 1)
Parathyroid gland N/A heterozygote 0.0% (0 of 1)
Peripheral nervous system N/A heterozygote 0.0% (0 of 1)
Peyer's patch N/A heterozygote 0.0% (0 of 1)
Pituitary gland N/A heterozygote 0.0% (0 of 1)
Prostate gland N/A heterozygote 0.0% (0 of 1)
Skeletal muscle N/A heterozygote 0.0% (0 of 1)
Skin N/A heterozygote 0.0% (0 of 1)
Small intestine N/A heterozygote 0.0% (0 of 1)
Spinal cord N/A heterozygote 0.0% (0 of 1)
Spleen N/A heterozygote 0.0% (0 of 1)
Stomach N/A heterozygote 0.0% (0 of 1)
Striatum N/A heterozygote 0.0% (0 of 1)
Thymus N/A heterozygote 0.0% (0 of 1)
Thyroid gland N/A heterozygote 0.0% (0 of 1)
Trachea N/A heterozygote 0.0% (0 of 1)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 1)
Urinary bladder N/A heterozygote 0.0% (0 of 1)
Uterus N/A heterozygote Not available
Vas deferens N/A heterozygote Ambiguous
Vascular system N/A heterozygote 0.0% (0 of 1)
White adipose tissue N/A heterozygote 0.0% (0 of 1)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric lymph node
olfactory lobe 0.0%
oral epithelium 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vas deferens Unavailable
vascular system 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left fundus

16 Images

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X-ray

XRay Images Whole Body Lateral Orientation

9 Images

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X-ray

XRay Images Whole Body Dorso Ventral

9 Images

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Eye Morphology

VIP of right fundus

16 Images

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X-ray

XRay Images Forepaw

8 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

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Eye Morphology

VIP of right eye

16 Images

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Adult LacZ

LacZ Images Wholemount

5 Images

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Eye Morphology

VIP of left eye

16 Images

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X-ray

XRay Images Skull Lateral Orientation

9 Images

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Human diseases caused by Adgrg7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adgrg7 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Retinal Dysplasia, Primary
Falciform retinal fold, Retinal dysplasia OMIM:312550
Deafness-Vitiligo-Achalasia Syndrome
Achalasia, Severe short stature ORPHA:3239
Visceral Myopathy 2
Intestinal obstruction, Rectal prolapse, Gastroparesis, Gastroesophageal reflux, Intestinal pseud... OMIM:619350
Deafness, Congenital, With Vitiligo And Achalasia
Short stature, Achalasia OMIM:221350
Achalasia-Microcephaly Syndrome
Achalasia OMIM:200450
Exudative Vitreoretinopathy 7
Retinal detachment, Exudative vitreoretinopathy, Retinal degeneration, Retinal hole, Retinal fold OMIM:617572
Mungan Syndrome
Gastroparesis, Intestinal pseudo-obstruction, Abdominal pain, Barrett esophagus, Hypoperistalsis,... OMIM:611376
Achalasia-Microcephaly Syndrome
Growth delay, Achalasia ORPHA:929
Peripheral Motor Neuropathy-Dysautonomia Syndrome
Achalasia ORPHA:2400
Cataract 50 With Or Without Glaucoma
Retinal detachment, Persistent pupillary membrane, Cataract OMIM:620253
Vitreoretinal Degeneration, Snowflake Type
Retinal detachment, Retinal dots, Corneal guttata, Optically empty vitreous, Cataract, Snowflake ... OMIM:193230
Dystonia-Deafness Syndrome 1
Achalasia, Small for gestational age, Dysphagia, Pseudobulbar paralysis OMIM:607371
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal neoplasm, Dyspepsia, Gastroesophageal reflux, Nasogastric tube feeding, Abnormal gastr... ORPHA:1018
Myopia, High, With Cataract And Vitreoretinal Degeneration
Retinal detachment, Peripheral vitreoretinal degeneration, Vitreous floaters, Lattice retinal deg... OMIM:614292
Retinitis Pigmentosa 13
Bone spicule pigmentation of the retina, Asteroid hyalosis, Cystoid macular edema, Optic disc dru... OMIM:600059
Congenital Short Bowel Syndrome
Abdominal distention, Steatorrhea, Projectile vomiting, Chronic diarrhea, Abnormal peristalsis, C... OMIM:615237
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Moyamoya Disease 6 With Or Without Achalasia
Achalasia, Dysphagia OMIM:615750
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 4
Abdominal distention, Hypoperistalsis OMIM:619365
Myopia 28, Autosomal Recessive
Retinal detachment, Cataract OMIM:619781
Immunodeficiency 70
Celiac disease, Achalasia, Colitis OMIM:618969
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome
Short stature, Achalasia ORPHA:436174
Triple A Syndrome
Short stature, Achalasia ORPHA:869
Developmental Malformations-Deafness-Dystonia Syndrome
Short stature, Achalasia, Dysphagia ORPHA:79107
Tetrasomy 18P
Achalasia ORPHA:3307
Ectopia Lentis Et Pupillae
Iris transillumination defect, Retinal detachment, Persistent pupillary membrane, Ectopia lentis,... OMIM:225200
Intellectual Developmental Disorder, X-Linked, Syndromic 17
Achalasia OMIM:300858
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Delayed puberty, Abnormal intestine morphology, Short stature, Exocrine pancreatic insufficiency,... OMIM:615952
Scleromyxedema
Hypoperistalsis, Dysphagia, Gastroesophageal reflux, Abnormality of the gastrointestinal tract ORPHA:167635
Oculogastrointestinal Muscular Dystrophy
Abdominal distention, Abnormality of the gastrointestinal tract, Gastroparesis, Intestinal pseudo... ORPHA:1876
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Abdominal distention, Abnormality of the gastrointestinal tract, Microcolon, Intestinal malrotati... ORPHA:2241
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Mirage Syndrome
Gastroesophageal reflux, Chronic diarrhea, Decreased body weight, Short stature, Intrauterine gro... OMIM:617053
Cleft Palate, Cardiac Defects, And Impaired Intellectual Development
Short stature, Achalasia, Feeding difficulties, Gastroesophageal reflux OMIM:600987
Proton-Pump Inhibitor-Responsive Esophageal Eosinophilia
Esophageal food impaction, Esophageal atresia, Gastroesophageal reflux, Eosinophilic microabscess... ORPHA:411696
American Trypanosomiasis
Aganglionic megacolon, Diarrhea, Abdominal pain, Abnormal large intestine physiology, Achalasia ORPHA:3386
Central Hypoventilation Syndrome, Congenital, 2, And Autonomic Dysfunction
Gastroesophageal reflux, Small intestinal dysmotility, Ineffective esophageal peristalsis, Dyspha... OMIM:619482
Intellectual Disability-Alacrima-Achalasia Syndrome
Achalasia, Dysphagia ORPHA:289483
Posterior Column Ataxia With Retinitis Pigmentosa
Achalasia OMIM:609033
Coats Disease
Retinal telangiectasia, Exudative retinal detachment, Leukocoria OMIM:300216
Smooth Muscle Dysfunction Syndrome
Intestinal malrotation, Hypoperistalsis OMIM:613834
Achalasia-Addisonianism-Alacrima Syndrome
Short stature, Achalasia OMIM:231550
Glucocorticoid Deficiency 2
Achalasia OMIM:607398
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 18
Esophagitis, Short stature, Feeding difficulties, Intrauterine growth retardation, Achalasia OMIM:615356
Central Hypoventilation Syndrome, Congenital, 1
Ineffective esophageal peristalsis, Aganglionic megacolon, Feeding difficulties, Chronic constipa... OMIM:209880
Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia
Short stature, Achalasia, Growth delay OMIM:616007
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome
Achalasia, Esophageal stenosis, Dysphagia, Feeding difficulties OMIM:615510
Fabry Disease
Delayed puberty, Anorexia, Abdominal pain, Short stature, Malabsorption, Nausea and vomiting, Ach... ORPHA:324

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adgrg7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adgrg7.

No publications found that use IMPC mice or data for Adgrg7.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Adgrg7tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Adgrg7tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adgrg7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Adgrg7tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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