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Gene: Dipk2b MGI:1923155

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Gene Summary

Name:
divergent protein kinase domain 2B
Synonyms:
4930578C19Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased freezing behavior Dipk2bem1(IMPC)Mbp HOM Early adult 3.22×10-06
abnormal bone structure Dipk2bem1(IMPC)Mbp HOM Early adult 4.88×10-08
decreased locomotor activity Dipk2bem1(IMPC)Mbp HOM Early adult 8.24×10-07
hydrometra Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
enlarged lymph nodes Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
abnormal skin morphology Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Dipk2bem1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

28 Images

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X-ray

XRay Images Whole Body Dorso Ventral

84 Images

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Human diseases caused by Dipk2b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dipk2b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy, Axillary lymphadenopathy, Inguinal lymphadenopathy OMIM:616126
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Mantle Cell Lymphoma
Anorexia, Splenomegaly, Lymphadenopathy ORPHA:52416
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Kerion Celsi
Lymphadenopathy ORPHA:499
Immunodeficiency 75 With Lymphoproliferation
Follicular hyperplasia, Hepatosplenomegaly, Lymphadenopathy OMIM:619126
Pandas
Anorexia, Irritability, Obsessive-compulsive trait, Abnormal fear-induced behavior, Depression, E... ORPHA:66624
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Irritability, Abnormal fear-induced behavior, Broad-based gait, Hyperactivity, Shufflin... ORPHA:3077
Mu-Heavy Chain Disease
Splenomegaly, Lymphadenopathy, Osteoporosis, Osteolysis ORPHA:100024
Classic Hodgkin Lymphoma
Anorexia, Lymphadenopathy, Bone marrow hypocellularity, Ataxia, Splenomegaly, Osteolysis ORPHA:391
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Anorexia, Splenomegaly, Lymphadenopathy ORPHA:86893
Immunodeficiency 104
Splenomegaly, Lymphadenopathy OMIM:608971
Laryngeal Neuroendocrine Tumor
Anorexia, Chronic noninfectious lymphadenopathy, Oral-pharyngeal dysphagia ORPHA:100083
Rosaï-Dorfman Disease
Lymphadenopathy, Osteolysis ORPHA:158014
Immunodeficiency With Hyper-Igm, Type 5
Epididymitis, Lymphadenopathy OMIM:608106
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Pseudobulbar paralysis, Abnormal fear-induced behavior, Aggressive behavior ORPHA:208441
Burkitt Lymphoma
Abnormal lymph node morphology, Abnormality of the spleen, Abnormality of the ovary ORPHA:543
Autoinflammation With Episodic Fever And Lymphadenopathy
Splenomegaly, Lymphadenopathy, Recurrent tonsillitis OMIM:618852
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Mast Cell Sarcoma
Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:66661
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Splenomegaly, Lymphadenopathy ORPHA:444463
Follicular Lymphoma
Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:545
Immunodeficiency 32A
Lymphadenitis, Lymphadenopathy OMIM:614893
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Abnormal lymph node morphology, Chronic noninfectious lymphadenopathy ORPHA:97290
Familial Papillary Or Follicular Thyroid Carcinoma
Abnormal lymph node morphology, Chronic noninfectious lymphadenopathy ORPHA:319487
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis, Abnormal lymph node morphology, Splenomegaly, Hepatosplenomegaly OMIM:612840
Immunodeficiency 27A
Anorexia, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Enlarged mesenteric lymph node OMIM:209950
Granulomatous Slack Skin
Abnormal lymph node morphology ORPHA:33111
Niemann-Pick Disease, Type A
Irritability, Lymphadenopathy, Inability to walk, Athetosis, Osteoporosis, Splenomegaly OMIM:257200
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant
Splenomegaly, Lymphadenopathy OMIM:615513
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Schnitzler Syndrome
Increased bone mineral density, Lymphadenopathy, Splenomegaly ORPHA:37748
Pleural Mesothelioma
Lymphadenopathy, Dysphagia ORPHA:50251
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Immunodeficiency 76
Splenomegaly, Lymphadenopathy OMIM:619164
Alpha-Heavy Chain Disease
Splenomegaly, Lymphadenopathy ORPHA:100025
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Gonadal dysgenesis, Steppage gait, Abnormal female external genitalia morphology, Male hypogonadi... ORPHA:168563
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Genital ulcers, Lymph node hypoplasia, Splenomegaly, Aplasia of the thymus, Absent tonsils, Gener... OMIM:602450
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:300853
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Indolent Systemic Mastocytosis
Splenomegaly, Lymphadenopathy, Osteoporosis ORPHA:98848
Immunodeficiency 64 With Lymphoproliferation
Mediastinal lymphadenopathy, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Cervical lymphade... OMIM:618534
Autoimmune Lymphoproliferative Syndrome, Type Iii
Mediastinal lymphadenopathy, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Generalized lymph... OMIM:615559
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Follicular hyperplasia, Lymphadenopathy OMIM:619846
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
46,Xy Sex Reversal 3
Gonadal dysgenesis, Clitoral hypertrophy, Penoscrotal hypospadias, Exaggerated rugosity of the la... OMIM:612965
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Splenomegaly, Hepatosplenomegaly, Lymphadenopathy OMIM:613101
Immunodeficiency, Common Variable, 2
Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:240500
Pfapa Syndrome
Splenomegaly, Lymphadenopathy ORPHA:42642
Leydig Cell Hypoplasia
Testicular gonadoblastoma, Hypospadias, Abnormal vas deferens morphology, Hypoplasia of the Leydi... ORPHA:755
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
46,Xx Ovotesticular Difference Of Sex Development
Abnormal male internal genitalia morphology, Hypospadias, Hypoplasia of penis, Abnormal scrotal r... ORPHA:2138
46,Xy Sex Reversal 11
Abnormal internal genitalia, Aplasia of the uterus, Urogenital sinus anomaly, Vanishing testis, G... OMIM:273250
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Caspase 8 Deficiency
Splenomegaly, Lymphadenopathy OMIM:607271
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Immunodeficiency 103, Susceptibility To Fungal Infections
Lymphadenopathy OMIM:212050
Rhabdoid Tumor
Irritability, Lymphadenopathy ORPHA:69077
Desmoplastic Small Round Cell Tumor
Testicular neoplasm, Ovarian neoplasm, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:83469
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Roifman Syndrome
Delayed proximal femoral epiphyseal ossification, Hypogonadotropic hypogonadism, Hepatosplenomega... ORPHA:353298
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormal lymph node morphology, Abnormal testis morphology ORPHA:54251
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Osteopenia, Hypoplasia of the uterus, Azoospermia, Decreased testicular size, Cryptorchidism, Mic... OMIM:614837
Fish-Eye Disease
Splenomegaly, Lymphadenopathy ORPHA:79292
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Lymphadenopathy ORPHA:2221
Immunodeficiency 109 With Lymphoproliferation
Generalized lymphadenopathy, Splenomegaly OMIM:620282
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Activated Pi3K-Delta Syndrome
Lymphadenopathy, Splenomegaly, Recurrent tonsillitis ORPHA:397596
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Tularemia
Abnormal nasopharyngeal adenoid morphology, Cervical lymphadenopathy, Mediastinal lymphadenopathy... ORPHA:3392
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Immune Dysregulation, Autoimmunity, And Autoinflammation
Cervical lymphadenopathy, Inguinal lymphadenopathy OMIM:620514
Aggressive Systemic Mastocytosis
Anorexia, Lymphadenopathy, Osteoporosis, Hepatosplenomegaly, Hypersplenism, Osteolysis ORPHA:98850
Gamma-Heavy Chain Disease
Splenomegaly, Dysphagia, Lymphadenopathy, Osteolysis ORPHA:100026
Thyroid Lymphoma
Lymphadenopathy, Dysphagia ORPHA:97285
Complete Androgen Insensitivity Syndrome
Blind vagina, Female external genitalia in individual with 46,XY karyotype, Testicular neoplasm, ... ORPHA:99429
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Immunodeficiency 105
Absence of lymph node germinal center, Hepatosplenomegaly OMIM:619924
Partial Androgen Insensitivity Syndrome
Blind vagina, Clitoral hypertrophy, Hypospadias, Azoospermia, Aplasia of the uterus, Bifid scrotu... ORPHA:90797
Mayer-Rokitansky-Kuster-Hauser Syndrome
Abnormal female external genitalia morphology, Aplasia of the upper vagina, Aplasia of the vagina... OMIM:277000
Leishmaniasis
Anorexia, Lymphadenopathy, Splenomegaly ORPHA:507
Scrub Typhus
Lymphadenopathy, Splenomegaly, Lethargy ORPHA:83317
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Splenomegaly, Lymphadenopathy OMIM:618495
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Hypospadias, Abnormal testis morphology, Vaginal neoplasm, Abnormality ... ORPHA:1916
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Splenomegaly, Lymphadenopathy OMIM:150550
Perrault Syndrome 4
Hypoplasia of the ovary, Bicornuate uterus, Osteoporosis, Gait ataxia, Hypoplasia of the uterus OMIM:615300
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Cold Agglutinin Disease
Splenomegaly, Lymphadenopathy ORPHA:56425
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Ras-Associated Autoimmune Leukoproliferative Disorder
Follicular hyperplasia, Splenomegaly OMIM:614470
Lymphoproliferative Syndrome 2
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:615122
46,Xy Sex Reversal 7
Streak ovary, Abnormal epididymis morphology, Gonadoblastoma, Hypoplasia of the fallopian tube, G... OMIM:233420
Griscelli Syndrome
Bone marrow hypocellularity, Ataxia, Splenomegaly, Lymphadenopathy ORPHA:381
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Anaplastic Thyroid Carcinoma
Lymphadenopathy, Dysphagia ORPHA:142
Heme Oxygenase 1 Deficiency
Cervical lymphadenopathy, Lymphadenopathy, Asplenia OMIM:614034
Immunodeficiency 7
Splenomegaly, Lymphadenopathy OMIM:615387
Primary Myelofibrosis
Anorexia, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:824
Porphyria Due To Ala Dehydratase Deficiency
Agitation, Difficulty walking, Abnormal fear-induced behavior, Depression, Restlessness ORPHA:100924
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Roifman Syndrome
Lymphadenopathy, Splenomegaly OMIM:616651
Griscelli Syndrome Type 2
Splenomegaly, Lymphadenopathy ORPHA:79477
Medullary Thyroid Carcinoma
Lymphadenopathy, Dysphagia ORPHA:1332
Joint Contractures, Osteochondromas, And B-Cell Lymphoma
Reduced bone mineral density, Generalized lymphadenopathy OMIM:620232
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Hereditary Amyloidosis With Primary Renal Involvement
Abnormal lymph node morphology, Primary testicular failure, Lymphadenopathy, Oligozoospermia, Abn... ORPHA:85450
Thymic Neuroendocrine Tumor
Neoplasm of the thymus, Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy, Osteo... ORPHA:97289
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Abnormal lymph node morphology, Hepatosplenomegaly, Lymphadenopathy ORPHA:911
Immunodeficiency 98 With Autoinflammation, X-Linked
Bone marrow hypocellularity, Myelofibrosis, Splenomegaly, Lymphadenopathy OMIM:301078
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Osteopenia, Absent peripheral lymph nodes in presence of infection ORPHA:98813
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Ataxia, Splenomegaly OMIM:613179
Legionnaires Disease
Anorexia, Lymphadenopathy, Bone marrow hypocellularity, Ataxia, Splenomegaly ORPHA:549
Castleman Disease
Mediastinal lymphadenopathy, Lymphadenopathy, Myelofibrosis, Generalized lymphadenopathy, Follicu... ORPHA:160
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:3226
Aregenerative Anemia
Depression, Bone marrow hypocellularity, Emotional lability, Lymphadenopathy ORPHA:101096
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Lymphadenopathy, Splenomegaly, Follicular hyperplasia OMIM:603909
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Hepatosplenomegaly, Lymphadenopathy OMIM:619750
Boutonneuse Fever
Cervical lymphadenopathy, Lymphadenopathy ORPHA:83313
Testicular Agenesis
Hypoplasia of the uterus, Abnormal vas deferens morphology, Urogenital sinus anomaly, Urethrovagi... ORPHA:325124
Tafro Syndrome
Splenomegaly, Hepatosplenomegaly, Lymphadenopathy, Myelofibrosis ORPHA:457077
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Splenomegaly, Follicular hyperplasia OMIM:601859
Cinca Syndrome
Lymphadenopathy, Reduced bone mineral density, Splenomegaly ORPHA:1451
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Lymphadenopathy, Recurrent tonsillitis, Lymphadenitis, Hepatosplenomegaly, Splenomegaly OMIM:618935
Systemic-Onset Juvenile Idiopathic Arthritis
Splenomegaly, Lymphadenopathy ORPHA:85414
Papa Syndrome
Lymphadenopathy ORPHA:69126
Felty Syndrome
Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy, Osteolysis ORPHA:47612
Mullerian Aplasia And Hyperandrogenism
Abnormal external genitalia, Aplasia of the uterus, Aplasia of the fallopian tube, Aplasia of the... OMIM:158330
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Irritability, Ataxia, Splenomegaly OMIM:267700
Nephroblastoma
Lymphadenopathy ORPHA:654
Lymphatic Filariasis
Lymphangiectasis, Lymphadenopathy, Abnormality of the lymphatic system, Lymphadenitis, Abnormal s... ORPHA:2035
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Sézary Syndrome
Lymphadenopathy, Splenomegaly ORPHA:3162
Hemophagocytic Lymphohistiocytosis, Familial, 2
Irritability, Lymphadenopathy, Ataxia, Splenomegaly, Hepatosplenomegaly OMIM:603553
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Neuroblastoma
Irritability, Ataxia, Lymphadenopathy, Antalgic gait ORPHA:635
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Female external genitalia in individual with 46,XY karyotype, Ambiguous genitalia, male, Clitoral... ORPHA:168558
Immunodeficiency 91 And Hyperinflammation
Hepatosplenomegaly, Lymphadenopathy OMIM:619644
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Ataxia, Splenomegaly ORPHA:36412
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Female external genitalia in individual with 46,XY karyotype, Ambiguous genitalia, male, Clitoral... ORPHA:289548
Hyperimmunoglobulinemia D With Periodic Fever
Ataxia, Lymphadenopathy ORPHA:343
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Poems Syndrome
Lymphadenopathy, Sclerosis of hand bone, Sclerosis of foot bone, Splenomegaly, Hypogonadism, Scle... ORPHA:2905
Proteasome-Associated Autoinflammatory Syndrome 4
Splenomegaly, Lymphadenopathy OMIM:619183
Lig4 Syndrome
Cryptorchidism, Lymphadenopathy, Hypoplasia of penis ORPHA:99812
Renal And Mullerian Duct Hypoplasia
Aplasia of the uterus, Anteriorly displaced urethral meatus, Hydrocele testis OMIM:266810
Cyclic Neutropenia
Cervical lymphadenopathy, Lymphadenopathy, Recurrent tonsillitis ORPHA:2686
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Mevalonic Aciduria
Fluctuating splenomegaly, Progressive cerebellar ataxia, Lymphadenopathy, Ataxia, Hepatosplenomegaly OMIM:610377
Immunodeficiency 97 With Autoinflammation
Lymphadenopathy, Mediastinal lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:619802
Mixed Connective Tissue Disease
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly, Osteolysis ORPHA:809
Familial Pancreatic Carcinoma
Anorexia, Ovarian carcinoma, Hepatosplenomegaly, Lymphadenopathy ORPHA:1333
Diffuse Cutaneous Mastocytosis
Lymphadenopathy, Abnormality of the spleen ORPHA:79456
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Lymphadenopathy, Splenomegaly OMIM:616100
H Syndrome
Lymphadenopathy, Azoospermia, Decreased testicular size, Hepatosplenomegaly, Hypogonadism, Microp... ORPHA:168569
Acute Promyelocytic Leukemia
Anorexia, Addictive alcohol use, Lymphadenopathy ORPHA:520
Omenn Syndrome
Lymphadenopathy, Splenomegaly ORPHA:39041
Acute Monoblastic/Monocytic Leukemia
Anorexia, Cervical lymphadenopathy ORPHA:514
46,Xx Sex Reversal 2
Hypoplasia of the uterus, Ovotestis, Azoospermia, Bifid scrotum, True hermaphroditism, Hypoplasia... OMIM:278850
Immunodeficiency 10
Lymphadenopathy, Splenomegaly OMIM:612783
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Blind vagina, Ambiguous genitalia, male, Female external genitalia in individual with 46,XY karyo... ORPHA:90793
46,Xy Difference Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Female external genitalia in individual with 46,XY karyotype, Ambiguous genitalia, male, Hypoplas... ORPHA:90796
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Waldenström Macroglobulinemia
Anorexia, Lymphadenopathy, Ataxia, Splenomegaly ORPHA:33226
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Klatskin Tumor
Lymphadenopathy ORPHA:99978
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Omenn Syndrome
Splenomegaly, Hypoplasia of the thymus, Lymphadenopathy OMIM:603554
Kikuchi-Fujimoto Disease
Anorexia, Abnormal lymph node morphology, Lymphadenopathy, Ataxia, Splenomegaly, Generalized lymp... ORPHA:50918
Pancreatoblastoma
Abnormal lymph node morphology ORPHA:677
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Abnormal fear-induced behavior ORPHA:309246
Adult-Onset Still Disease
Bone marrow hypocellularity, Generalized lymphadenopathy, Splenomegaly, Lymphadenopathy ORPHA:829
Lumbar Syndrome
Hypospadias, Bifid scrotum, Bifid uterus, Ambiguous genitalia, Cryptorchidism, Micropenis, Hypopl... ORPHA:83628
Graft Versus Host Disease
Irritability, Hepatosplenomegaly, Lymphadenopathy ORPHA:39812
Agammaglobulinemia, X-Linked
Prostatitis, Lymph node hypoplasia, Epididymitis OMIM:300755
Carney Triad
Anorexia, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Enlarged tonsils, Hepatosplenomegaly, Lymphadenopathy OMIM:606367
Neuroendocrine Tumor Of The Colon
Anorexia, Chronic noninfectious lymphadenopathy ORPHA:100080
Immunodeficiency, Common Variable, 8, With Autoimmunity
Lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:614700
Chediak-Higashi Syndrome
Lymphadenopathy, Ataxia, Splenomegaly, Gait disturbance OMIM:214500
Pituitary Adenoma 4, Acth-Secreting
Emotional lability, Abnormal fear-induced behavior, Osteoporosis OMIM:219090
Immunodeficiency With Hyper-Igm, Type 1
Absence of lymph node germinal center, Enlarged tonsils, Splenomegaly OMIM:308230
Macrophage Activation Syndrome
Lymphadenopathy, Splenomegaly ORPHA:158061
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Lymphadenopathy, Splenomegaly ORPHA:436159
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Hilar lymph node enlargement, Mediastinal lymphadenopathy, Lethargy OMIM:620233
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Hydatidiform Mole
Enlarged uterus ORPHA:99927
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Farber Disease
Hepatosplenomegaly, Lymphadenopathy, Osteoporosis ORPHA:333
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Mayer-Rokitansky-Küster-Hauser Syndrome
Endometriosis, Aplasia of the uterus, Ectopic ovary, Hypoplasia of the vagina, Aplasia of the ovary ORPHA:3109
Histiocytosis-Lymphadenopathy Plus Syndrome
Lymphadenopathy, Azoospermia, Hypergonadotropic hypogonadism, Hepatosplenomegaly, Splenomegaly, M... OMIM:602782
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:615895
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Uterus didelphys, Septate vagina, Aplasia of the uterus, Aplasia of the vagina OMIM:146255
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Hyper-Igd Syndrome
Lymphadenitis, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:260920
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Agitation, Lymphadenopathy, Bone marrow hypocellularity, Ataxia, Splenomegaly, Hepatosplenomegaly OMIM:615688
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly, Osteoporosis ORPHA:98849
Chikungunya
Periostitis, Lymphadenopathy, Depression, Cervical lymphadenopathy, Osteolysis ORPHA:324625
Coccidioidomycosis
Abnormality of the female genitalia, Mediastinal lymphadenopathy, Lymphadenopathy, Abnormality of... ORPHA:228123
Multiple Myeloma
Osteopenia, Lymphadenopathy, Splenomegaly ORPHA:29073
Lymphangioleiomyomatosis
Abnormality of the lymphatic system, Pulmonary lymphangiomyomatosis, Lymphadenopathy, Abnormal mo... ORPHA:538
Congenital Syphilis
Periostitis, Hepatosplenomegaly, Lymphadenopathy ORPHA:499009
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Proteasome-Associated Autoinflammatory Syndrome 3
Lymphadenopathy, Splenomegaly OMIM:617591
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233710
Drug Reaction With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Q Fever
Anorexia, Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:781
Behçet Disease
Anorexia, Irritability, Lymphadenopathy, Gait disturbance, Ataxia, Orchitis, Splenomegaly ORPHA:117
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233690
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Meckel Syndrome 14
Decreased calvarial ossification, Ambiguous genitalia, Aplasia of the uterus OMIM:619879
Riddle Syndrome
Emotional lability, Generalized lymphadenopathy, Ataxia, Gait disturbance ORPHA:420741
Immunodeficiency 31C
Osteopenia, Lymphadenopathy, Splenomegaly OMIM:614162
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Absence of lymph node germinal center, Hepatosplenomegaly ORPHA:79124
Townes-Brocks Syndrome 2
Bifid uterus, Hypospadias, Rectovaginal fistula OMIM:617466
Gallbladder Neuroendocrine Tumor
Anorexia, Chronic noninfectious lymphadenopathy ORPHA:100086
Chédiak-Higashi Syndrome
Inability to walk, Lymphadenopathy, Gait disturbance, Hepatosplenomegaly, Splenomegaly, Ataxia ORPHA:167
Fanconi Anemia, Complementation Group L
Attention deficit hyperactivity disorder, Bone marrow hypocellularity, Aplasia of the uterus, Mic... OMIM:614083
Spondyloenchondrodysplasia With Immune Dysregulation
Sclerosis of skull base, Lymphadenopathy OMIM:607944
Oeis Complex
Epispadias, Ambiguous genitalia, male, Rectovaginal fistula, Vesicovaginal fistula, Labial hypopl... OMIM:258040
Hennekam Syndrome
Lymphadenopathy, Lymphangioma, Splenomegaly, Pulmonary lymphangiectasia, Craniosynostosis ORPHA:2136
Familial Mediterranean Fever
Depression, Lymphadenopathy, Orchitis, Splenomegaly ORPHA:342
Acute Generalized Exanthematous Pustulosis
Lymphadenopathy ORPHA:293173
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Lymphadenopathy, Splenomegaly, Polysplenia, Accessory spleen OMIM:619418
Autosomal Recessive Malignant Osteopetrosis
Osteopetrosis, Reduced bone mineral density, Lymphadenopathy, Splenomegaly, Craniosynostosis ORPHA:667
T-Cell Immunodeficiency With Thymic Aplasia
Lymphadenopathy, Aplasia of the thymus ORPHA:83471
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Cervical lymphadenopathy, Lymphadenopathy OMIM:617718
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Clitoral hypertrophy, Premature pubarche, Precocious puberty in females, Long penis, Abnormal ext... ORPHA:90794
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Uterus didelphys, Septate vagina, Aplasia of the uterus, Vaginal atresia ORPHA:2237
Immunodeficiency 82 With Systemic Inflammation
Anorexia, Lymphadenopathy, Anoperineal fistula, Splenomegaly, Osteomalacia, Follicular hyperplasia OMIM:619381
Neuroendocrine Neoplasm Of Appendix
Anorexia, Ovarian neoplasm, Chronic noninfectious lymphadenopathy ORPHA:100079
Chromosome 17Q12 Deletion Syndrome
Aplasia of the vagina, Aplasia of the uterus, Unicornuate uterus, Ovarian cyst, Cryptorchidism, Pica OMIM:614527
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:306400
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Brucellosis
Anorexia, Lymphadenopathy, Depression, Epididymitis, Orchitis, Splenomegaly, Hypersplenism ORPHA:1304
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy ORPHA:331235
Sarcoidosis, Susceptibility To, 1
Anorexia, Mediastinal lymphadenopathy, Bone cyst, Splenomegaly, Generalized lymphadenopathy OMIM:181000
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus ORPHA:2736
Cardiac-Urogenital Syndrome
Penoscrotal hypospadias, Accessory spleen, Aplasia of the uterus, Bifid scrotum, Unilateral crypt... OMIM:618280
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Orchitis, Splenomegaly ORPHA:32960
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Hyperactivity, Aplasia of the uterus, Aplasia of the vagina ORPHA:457284
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Craniosynostosis, Bifid uterus, Abnormal reproductive system morphology ORPHA:1521
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Autoimmune Lymphoproliferative Syndrome
Lymphadenopathy, Chronic noninfectious lymphadenopathy, Bone marrow hypocellularity, Splenomegaly... ORPHA:3261
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the uterus, Absent external genitalia, Aplasia of the vagina OMIM:271520
Cushing Syndrome Due To Ectopic Acth Secretion
Anorexia, Abnormal lymph node morphology, Depression, Emotional lability, Neoplasm of the thymus,... ORPHA:99889
Pontocerebellar Hypoplasia Type 7
Gonadal dysgenesis, Clitoral hypertrophy, Abnormal scrotal rugation, Aplasia of the uterus, Micro... ORPHA:284339
Marburg Hemorrhagic Fever
Anorexia, Lymphadenopathy, Orchitis, Lethargy, Aggressive behavior ORPHA:99826
Tangier Disease
Orange discolored tonsils, Hepatosplenomegaly, Chronic noninfectious lymphadenopathy ORPHA:31150
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Hepatosplenomegaly, Lymphadenopathy ORPHA:85408
African Trypanosomiasis
Irritability, Akinesia, Difficulty walking, Lymphadenopathy, Gait disturbance, Hepatosplenomegaly... ORPHA:3385
Crimean-Congo Hemorrhagic Fever
Anorexia, Agitation, Lymphadenopathy, Emotional lability, Epididymitis, Orchitis, Splenomegaly ORPHA:99827
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Hypospadias, Emotional lability, Hyperactivity, Compulsive behavi... ORPHA:353281
Primary Sjögren Syndrome
Depression, Vaginal dryness, Lymphadenopathy ORPHA:289390
Wolf-Hirschhorn Syndrome
Hypospadias, Abnormal sternal ossification, Accessory spleen, Aplasia of the uterus, Precocious p... OMIM:194190
Sarcoidosis
Bone cyst, Abnormal lymph node morphology, Lymphadenopathy, Abnormal reproductive system morphology ORPHA:797
Systemic Lupus Erythematosus
Anorexia, Lymphadenopathy, Depression ORPHA:536
Igg4-Related Submandibular Gland Disease
Prostatitis, Lymphadenopathy ORPHA:449432
Phocomelia, Schinzel Type
Cryptorchidism, Aplasia of the uterus, Hypoplasia of penis ORPHA:2879
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus, Hepatosplenomegaly OMIM:274000
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Plague
Anorexia, Depression, Lymphadenitis, Unsteady gait, Splenomegaly, Enlarged mesenteric lymph node ORPHA:707
Igg4-Related Kidney Disease
Lymphadenitis, Prostatitis, Lymphadenopathy ORPHA:449395
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Aggressive behavior, Hypospadias, Abnormal fear-induced behavior, Emotional lability, Hyperactivi... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Aggressive behavior, Hypospadias, Abnormal fear-induced behavior, Emotional lability, Hyperactivi... ORPHA:353277
Coffin-Siris Syndrome 1
Clitoral hypertrophy, Hypospadias, Aplasia of the uterus, Compulsive behaviors, Gait ataxia, Cryp... OMIM:135900
Igg4-Related Ophthalmic Disease
Orchitis, Prostatitis, Lymphadenopathy ORPHA:449563
Proteasome-Associated Autoinflammatory Syndrome 1
Epididymitis, Lymphadenopathy, Splenomegaly OMIM:256040
Hydrolethalus Syndrome 1
Abnormal vagina morphology, Bifid uterus, Hypospadias, Accessory spleen OMIM:236680
Limb-Mammary Syndrome
Aplasia of the uterus, Aplasia of the ovary ORPHA:69085
Exstrophy-Epispadias Complex
Penoscrotal transposition, Epispadias, Bifid penis, Bifid scrotum, Absent penis, Bifid uterus, Cy... ORPHA:322
Ehlers-Danlos Syndrome, Vascular Type
Osteolytic defects of the phalanges of the hand, Cervical insufficiency, Cryptorchidism, Uterine ... OMIM:130050
Norrie Disease
Irritability, Cryptorchidism, Motor stereotypy, Attention deficit hyperactivity disorder, Self-in... ORPHA:649
Okamoto Syndrome
Bifid uterus, Splenomegaly ORPHA:2729
Igg4-Related Dacryoadenitis And Sialadenitis
Lymphadenopathy ORPHA:79078
Leptospirosis
Anorexia, Lymphadenopathy ORPHA:509
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Hypospadias, Anteriorly displaced genitalia, Aplasia of the uterus, Decreased calvarial ossificat... OMIM:276820
Blau Syndrome
Lymphadenopathy, Splenomegaly ORPHA:90340
Loeys-Dietz Syndrome
Craniosynostosis, Uterine rupture ORPHA:60030
Neu-Laxova Syndrome 1
Bifid uterus, Cryptorchidism OMIM:256520
Townes-Brocks Syndrome 1
Hypospadias, Rectovaginal fistula, Bifid scrotum, Rectoperineal fistula, Bifid uterus, Cryptorchi... OMIM:107480
Vascular Ehlers-Danlos Syndrome
Hypospadias, Uterine rupture, Uterine prolapse, Cystocele, Cryptorchidism, Osteolysis ORPHA:286
Pallister-Killian Syndrome
Aplasia of the upper vagina, Inability to walk, Hypospadias, Labial hypoplasia, Aplasia of the ut... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dipk2b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dipk2b.

No publications found that use IMPC mice or data for Dipk2b.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dipk2bem1(IMPC)Mbp Exon Deletion Mice, Tissue
Dipk2btm378701(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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