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Gene: Taok2 MGI:1915919

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Gene Summary

Name:
TAO kinase 2
Synonyms:
1110033K02Rik,  TAO2,  MAP3K17,  TAO1,  PSK1

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Taok2tm1b(EUCOMM)Hmgu HET Early adult 2.76×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Human diseases caused by Taok2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taok2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Plasma Fibronectin Deficiency
Reduced circulating fibronectin level OMIM:614101
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormal circulating enzyme concentration ORPHA:2843
Vacuolar Myopathy With Sarcoplasmic Reticulum Protein Aggregates
Elevated circulating creatine kinase concentration ORPHA:88635
Kleine-Levin Syndrome
Polydipsia, Agitation, Abnormal eating behavior, Transient global amnesia, Confusion, Polyphagia,... ORPHA:33543
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Erythrocyte Lactate Transporter Defect
Elevated circulating creatine kinase concentration OMIM:245340
Hereditary Central Diabetes Insipidus
Polydipsia ORPHA:30925
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Central Diabetes Insipidus
Polydipsia, Anorexia ORPHA:178029
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Nephronophthisis 9
Polydipsia OMIM:613824
Familial Cold Urticaria
Polydipsia ORPHA:47045
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 17
Polydipsia, Cognitive impairment OMIM:615994
Ochoa Syndrome
Polydipsia ORPHA:2704
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Alpha-Fetoprotein, Hereditary Persistence Of
Elevated circulating alpha-fetoprotein concentration OMIM:615970
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Nephronophthisis 4
Polydipsia OMIM:606966
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Cystinosis
Polydipsia, Motor stereotypy ORPHA:213
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia OMIM:304800
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Pediatric-Onset Graves Disease
Polydipsia, Polyphagia, Hyperactivity ORPHA:525731
Nephrogenic Diabetes Insipidus
Polydipsia, Anorexia ORPHA:223
Nephronophthisis 1
Polydipsia OMIM:256100
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Senior-Boichis Syndrome
Attention deficit hyperactivity disorder, Polydipsia, Agitation, Aggressive behavior ORPHA:84081
Whipple Disease
Polydipsia, Anorexia ORPHA:3452
Nephronophthisis 11
Polydipsia OMIM:613550
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Infantile Nephropathic Cystinosis
Polydipsia, Cognitive impairment ORPHA:411629
Nephronophthisis 3
Polydipsia OMIM:604387
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia OMIM:617994
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Renal Hypoplasia
Polydipsia ORPHA:93101
Wolfram Syndrome
Polydipsia, Dementia ORPHA:3463
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Helix Syndrome
Polydipsia OMIM:617671
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Panhypophysitis
Polydipsia ORPHA:95513
Brain-Lung-Thyroid Syndrome
Hyperactivity, Compulsive behaviors, Short attention span, Abnormal drinking behavior, Abnormal e... ORPHA:209905
Gitelman Syndrome
Polydipsia, Salt craving OMIM:263800
Oligomeganephronia
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Rabson-Mendenhall Syndrome
Polydipsia ORPHA:769
Erdheim-Chester Disease
Polydipsia ORPHA:35687
Cystinosis, Nephropathic
Polydipsia, Dysphagia, Progressive neurologic deterioration OMIM:219800
Hyperparathyroidism-Jaw Tumor Syndrome
Polydipsia, Dysphagia ORPHA:99880
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Polyphagia, Compulsive behaviors, Self-injurious behavior, Aggressive behavior ORPHA:293987
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Parathyroid Carcinoma
Polydipsia, Dysphagia ORPHA:143
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Autosomal Recessive Polycystic Kidney Disease
Polydipsia, Cognitive impairment ORPHA:731
Arima Syndrome
Polydipsia OMIM:243910
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Gitelman Syndrome
Polydipsia, Salt craving ORPHA:358
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Bartter Syndrome, Type 2, Antenatal
Polydipsia OMIM:241200
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Alpha-Fetoprotein Deficiency
Decreased circulating alpha-fetoprotein concentration OMIM:615969

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taok2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taok2.

No publications found that use IMPC mice or data for Taok2.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Taok2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Taok2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Taok2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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