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Gene: Nrk MGI:1351326

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Nik related kinase
Synonyms:
Nesk

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nrk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nrk by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Asherman Syndrome
Abnormal placenta morphology, Secondary amenorrhea, Miscarriage, Infertility, Oligomenorrhea, Dys... ORPHA:137686
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Large placenta, Polyhydramnios, Umbilical hernia ORPHA:254534
Placental Insufficiency
Abnormal placenta morphology, Abnormal umbilical cord blood vessel morphology, Miscarriage, Small... ORPHA:439167
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death, Premature birth OMIM:301021
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Large placenta, Polyhydramnios, Umbilical hernia ORPHA:254528
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Polyhydramnios, Neonatal death, Fetal akinesia sequence OMIM:619602
Greenberg Dysplasia
Stillbirth, Large placenta, Hydrops fetalis, Polyhydramnios, Increased nuchal translucency, Neona... OMIM:215140
Diaphragmatic Hernia 5, X-Linked
Neonatal death OMIM:306950
Congenital Syphilis
Hydrops fetalis, Large placenta, Premature birth ORPHA:499009
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Premature birth ORPHA:254519
Trichohepatoenteric Syndrome 1
Large placenta, Polyhydramnios, Abnormalities of placenta or umbilical cord OMIM:222470
Mosaic Trisomy 16
Single umbilical artery, Large placenta, Premature birth ORPHA:1708
Restrictive Dermopathy 1
Stillbirth, Short umbilical cord, Polyhydramnios, Neonatal death, Premature birth, Decreased feta... OMIM:275210
Ichthyosis, Congenital, Autosomal Recessive 4B
Neonatal death, Premature birth, Death in infancy OMIM:242500
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Restrictive Dermopathy
Short umbilical cord, Large placenta, Polyhydramnios, Small placenta, Premature birth, Premature ... ORPHA:1662
Lymphatic Malformation 12
Polyhydramnios, Death in adolescence, Fetal pericardial effusion, Fetal pleural effusion, Neonata... OMIM:620014
Silver-Russell Syndrome Due To A Point Mutation
Small placenta, Dysmenorrhea, Oligohydramnios ORPHA:397590
Meckel Syndrome, Type 1
Single umbilical artery, Occipital encephalocele, Large placenta, Breech presentation, Anencephal... OMIM:249000
Arthrogryposis Multiplex Congenita 6
Polyhydramnios, Death in childhood, Death in infancy, Neonatal death, Decreased fetal movement OMIM:619334
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small placenta, Hypogonadism ORPHA:73272
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Large placenta, Polyhydramnios, Miscarriage, Premature birth, Spinal dysraphism ORPHA:96334
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Large placenta, Polyhydramnios, Premature birth, Umbilical hernia ORPHA:116
Ulnar Agenesis And Endocardial Fibroelastosis
Hydrops fetalis, Neonatal death OMIM:276822
Fetal Akinesia Deformation Sequence 1
Stillbirth, Short umbilical cord, Polyhydramnios, Small placenta, Increased nuchal translucency, ... OMIM:208150
Neu-Laxova Syndrome 1
Stillbirth, Short umbilical cord, Polyhydramnios, Small placenta, Hydranencephaly, Spina bifida, ... OMIM:256520

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nrk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nrk.

No publications found that use IMPC mice or data for Nrk.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nrktm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nrktm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nrktm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells

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