Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Tesk1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cramps, Familial Adolescent | Elevated circulating creatine kinase concentration | OMIM:218050 | |
Isolated Asymptomatic Elevation Of Creatine Phosphokinase | Elevated circulating creatine kinase concentration | ORPHA:206599 | |
Muscle Cramps, Familial | Elevated circulating creatine kinase concentration | OMIM:158400 | |
Plasma Fibronectin Deficiency | Reduced circulating fibronectin level | OMIM:614101 | |
Pentosuria | Abnormal circulating carbohydrate concentration, Abnormal circulating enzyme concentration | ORPHA:2843 | |
Vacuolar Myopathy With Sarcoplasmic Reticulum Protein Aggregates | Elevated circulating creatine kinase concentration | ORPHA:88635 | |
Erythrocyte Lactate Transporter Defect | Elevated circulating creatine kinase concentration | OMIM:245340 | |
Alpha-Fetoprotein, Hereditary Persistence Of | Elevated circulating alpha-fetoprotein concentration | OMIM:615970 | |
Alpha-Fetoprotein Deficiency | Decreased circulating alpha-fetoprotein concentration | OMIM:615969 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Tesk1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Tesk1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Tesk1em1(IMPC)J | Exon Deletion | Mice |
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