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Gene: Cxcl1 MGI:108068

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Gene Summary

Name:
C-X-C motif chemokine ligand 1
Synonyms:
Gro1,  KC/GRO-alpha,  Scyb1,  Mgsa,  KC,  Fsp,  N51

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral content Cxcl1em1(IMPC)Mbp HOM Early adult 2.93×10-05
decreased bone mineral density Cxcl1em1(IMPC)Mbp HOM Early adult 4.18×10-05
abnormal eye morphology Cxcl1em1(IMPC)Mbp HOM Early adult 0.00
increased monocyte cell number Cxcl1em1(IMPC)Mbp HOM Early adult 3.07×10-05
abnormal lymph node morphology Cxcl1em1(IMPC)Mbp HOM Early adult 0.00
enlarged lymph nodes Cxcl1em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

102 Images

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X-ray

XRay Images Whole Body Lateral Orientation

34 Images

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Human diseases caused by Cxcl1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cxcl1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancytopenia, Lymphocytosis, Splenomegaly, Hemolytic anemia, Autoimmune thrombocytopenia, Monocyt... OMIM:614470
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy, Axillary lymphadenopathy, Inguinal lymphadenopathy OMIM:616126
Pulmonary Nodular Lymphoid Hyperplasia
Plasmacytosis, Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Anemia, Thrombocytosis, Congenital agranulocytosis, Acute monocytic leukemia, Eosinophilia, Monoc... OMIM:202700
Neutropenia, Severe Congenital, 2, Autosomal Dominant
B lymphocytopenia, Monocytosis, Neutropenia OMIM:613107
Neutropenia, Severe Congenital, 10, Autosomal Recessive
Anorectal abscess, Anemia, Thrombocytopenia, Monocytosis, Neutropenia OMIM:620534
Myeloproliferative/Lymphoproliferative Neoplasms, Familial (Multiple Types), Susceptibility To
Acute myeloid leukemia, Monocytosis, Bone marrow hypocellularity, Leukopenia, Refractory anemia OMIM:616871
Reticuloendotheliosis, X-Linked
Anemia, Lymphadenopathy, Hepatosplenomegaly OMIM:312500
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Immunodeficiency 75 With Lymphoproliferation
Follicular hyperplasia, Hepatosplenomegaly, Lymphadenopathy, Decreased proportion of class-switch... OMIM:619126
Mu-Heavy Chain Disease
Anemia, Lymphadenopathy, Osteoporosis, Splenomegaly, Abnormal B cell count, Osteolysis ORPHA:100024
Kerion Celsi
Recurrent cutaneous abscess formation, Lymphadenopathy ORPHA:499
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Immunodeficiency 14B, Autosomal Recessive
Monocytosis, B lymphocytopenia, Leukocytosis, Neutrophilia, Thrombocytosis OMIM:619281
Immunodeficiency 15B
Monocytosis, Reduced natural killer cell count OMIM:615592
Autosomal Dominant Severe Congenital Neutropenia
Osteopenia, Aplastic anemia, Acute myeloid leukemia, Acute lymphoblastic leukemia, Lymphopenia, E... ORPHA:486
Immunodeficiency 91 And Hyperinflammation
Hemophagocytosis, Lymphadenopathy, Neutrophilia, Thrombocytopenia, Hepatosplenomegaly, Monocytosis OMIM:619644
Kimura Disease
Follicular hyperplasia, Eosinophilia, Lymphadenopathy ORPHA:482
Rosaï-Dorfman Disease
Anemia, Lymphadenopathy, Osteolysis ORPHA:158014
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Autoimmune hemolytic anemia, Lymphadenopathy, Splenomegaly, Lymphopenia, Autoimmune thrombocytope... ORPHA:444463
Adult Idiopathic Neutropenia
Monocytopenia, Monocytosis, Neutropenia, Lymphopenia ORPHA:2688
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Lymphadenopathy, Decreased proportion of class-switched memory B cells, Lymphopenia, Decreased pr... OMIM:619846
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis, Anemia, Abnormal lymph node morphology, Leukocytosis, Hepatosplenomegaly, Splenome... OMIM:612840
Immunodeficiency 104
Lymphadenopathy, Splenomegaly, T lymphocytopenia OMIM:608971
Indolent Systemic Mastocytosis
Increased proportion of CD25+ mast cells, Lymphadenopathy, Osteoporosis, Mastocytosis, Splenomega... ORPHA:98848
Schnitzler Syndrome
Anemia, Lymphadenopathy, Increased bone mineral density, Arthritis, Leukocytosis, Splenomegaly ORPHA:37748
Immunodeficiency 52
Lymphadenopathy, Abnormal natural killer cell count, T lymphocytopenia, Splenomegaly, Abnormal B ... OMIM:617514
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Arthritis, Lymphadenopathy OMIM:617772
Immunodeficiency 76
Lymphadenopathy, B lymphocytopenia, T lymphocytopenia, Splenomegaly, Lymphopenia OMIM:619164
Immunodeficiency 103, Susceptibility To Fungal Infections
Lymphadenopathy, Abnormal natural killer cell count, Abnormal proportion of CD8-positive T cells,... OMIM:212050
Immunodeficiency 105
Impaired lymphocyte transformation with phytohemagglutinin, Pancytopenia, B lymphocytopenia, Incr... OMIM:619924
Mast Cell Sarcoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly, Mastocytosis ORPHA:66661
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant
Lymphadenopathy, Decreased proportion of class-switched memory B cells, Increased proportion of t... OMIM:615513
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Autoimmune hemolytic anemia, Fluctuating splenomegaly, Lymphadenopathy, Neutropenia in presence o... OMIM:619220
Autoinflammation With Episodic Fever And Lymphadenopathy
Lymphadenopathy, Microcytic anemia, Splenomegaly, Recurrent tonsillitis OMIM:618852
Immunodeficiency 27A
Anemia, Lymphadenopathy, Salmonella osteomyelitis, Leukocytosis, Hepatosplenomegaly, Splenomegaly... OMIM:209950
Immunodeficiency 32A
Granuloma, Lymphadenitis, Lymphadenopathy OMIM:614893
Immunodeficiency 97 With Autoinflammation
Autoimmune hemolytic anemia, Decreased proportion of CD8-positive T cells, Hemophagocytosis, Medi... OMIM:619802
Lymphoproliferative Syndrome 3
Reduced natural killer cell count, Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Hemophagocytic Lymphohistiocytosis, Familial, 4
Anemia, Hemophagocytosis, Lymphadenopathy, Thrombocytopenia, Splenomegaly, Neutropenia OMIM:603552
Immunodeficiency 21
Aplastic anemia, Anemia, Neutropenia, B lymphocytopenia, Lymphopenia, Monocytopenia, Reduced natu... OMIM:614172
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Pancytopenia, B lymphocytopenia, Lymphadenitis, T lymphocytopenia, Leukopenia, Hepatosplenomegaly... OMIM:618986
Immunodeficiency With Hyper-Igm, Type 4
Autoimmune hemolytic anemia, Absence of lymph node germinal center, Autoimmune thrombocytopenia, ... OMIM:608184
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Increased B cell count, Hepatosplenomegaly, Lymphadenopathy, Increased proportion of memory T cells OMIM:618982
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Abnormally low T cell receptor excision circle level, B lymphocytopenia, Cervical lymphadenopathy OMIM:618987
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Lymphadenopathy, Decreased proportion of CD4-positive helper T cells... OMIM:300853
Immunodeficiency 27B
Salmonella osteomyelitis, Generalized lymphadenopathy, Osteomyelitis OMIM:615978
Immunodeficiency 98 With Autoinflammation, X-Linked
Autoimmune hemolytic anemia, Hemophagocytosis, Lymphadenopathy, B lymphocytopenia, Myelofibrosis,... OMIM:301078
Immunodeficiency 64 With Lymphoproliferation
Autoimmune hemolytic anemia, Cervical lymphadenopathy, Mediastinal lymphadenopathy, Lymphadenopat... OMIM:618534
Autoimmune Lymphoproliferative Syndrome, Type Iii
Autoimmune hemolytic anemia, Mediastinal lymphadenopathy, Lymphadenopathy, Decreased proportion o... OMIM:615559
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Anemia, Hemophagocytosis, Lymphadenopathy, Thrombocytopenia, Splenomegaly, Hepatosplenomegaly OMIM:613101
Neutropenia, Severe Congenital, X-Linked
Monocytopenia, Decreased CD4:CD8 ratio, Neutropenia OMIM:300299
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Recurrent fractures, Abnormal lymph node morphology, Chronic noninfectious lymphadenopathy ORPHA:97290
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Neutropenia, Lymphadenopathy, B lymphocytopenia, Intermittent thrombocytopenia, Splenomegaly, Abs... OMIM:150550
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center, Neutropenia OMIM:606843
Ghosal Hematodiaphyseal Dysplasia
Increased bone mineral density, Refractory anemia, Myelofibrosis, Bone marrow hypocellularity, Th... OMIM:231095
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Leukocytosis, Splenomegaly, Arthritis OMIM:611762
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Familial Papillary Or Follicular Thyroid Carcinoma
Recurrent fractures, Abnormal lymph node morphology, Chronic noninfectious lymphadenopathy ORPHA:319487
Aggressive Systemic Mastocytosis
Anemia, Increased proportion of CD25+ mast cells, Lymphadenopathy, Pancytopenia, Leukemia, Leukoc... ORPHA:98850
Immunodeficiency 32B
Anemia, Monocytopenia, Neutrophilia, Thrombocytopenia, Splenomegaly, Eosinophilia, Impaired oxida... OMIM:226990
Joint Contractures, Osteochondromas, And B-Cell Lymphoma
Ankle flexion contracture, Reduced bone mineral density, Hip contracture, Knee flexion contractur... OMIM:620232
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Aplasia of the thymus, B lymphocytopenia, Lymph node hypoplasia, Splenomegaly, Lymphopenia, Abnor... OMIM:602450
Gamma-Heavy Chain Disease
Autoimmune hemolytic anemia, Anemia, Lymphadenopathy, Abnormal lymphocyte morphology, Rheumatoid ... ORPHA:100026
Follicular Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Pfapa Syndrome
Lymphadenopathy, Splenomegaly, Arthritis ORPHA:42642
Classic Hodgkin Lymphoma
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly, Osteolysis ORPHA:391
Burkitt Lymphoma
Decreased proportion of CD4-positive helper T cells, Abnormal lymph node morphology, Abnormality ... ORPHA:543
Alpha-Heavy Chain Disease
Lymphadenopathy, Anemia, Splenomegaly ORPHA:100025
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
B lymphocytopenia, T lymphocytopenia, Absence of lymph node germinal center, Lymphopenia, Absent ... ORPHA:277
Cinca Syndrome
Anemia, Lymphadenopathy, Arthritis, Leukocytosis, Hepatosplenomegaly, Eosinophilia OMIM:607115
Immunodeficiency 113 With Autoimmunity And Autoinflammation
Autoimmune hemolytic anemia, Leukocytosis, Neutrophilia, Splenomegaly, Autoimmune thrombocytopeni... OMIM:620565
Neutropenia, Severe Congenital, 4, Autosomal Recessive
Perianal abscess, Anemia, Erythroid hypoplasia, Hypoplasia of the thymus, Leukopenia, Splenomegal... OMIM:612541
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Iron deficiency anemia, Neutropenia in presence of anti-neutropil an... OMIM:601859
Autoimmune Lymphoproliferative Syndrome, Type Iia
Autoimmune hemolytic anemia, Iron deficiency anemia, Lymphadenopathy, Neutropenia in presence of ... OMIM:603909
Immunodeficiency 11A
Monocytopenia, Decreased proportion of CD4+CD25+ regulatory T cells OMIM:615206
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Liver abscess, Abnormal lymph node morphology, Anemia, Abnormality of the lymphatic system, Neutr... ORPHA:54251
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Decreased proportion of class-switched memory B cells, B lymphocytopenia, Neutro... OMIM:607594
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Decreased proportion of class-switched memory B cells, Coombs-positive hemolytic... OMIM:619375
Lymphoproliferative Syndrome, X-Linked, 1
Aplastic anemia, Hemophagocytosis, Lymphadenopathy, Pancytopenia, Lymphocytosis, Abnormal T cell ... OMIM:308240
Tularemia
Cervical lymphadenopathy, Anemia, Mediastinal lymphadenopathy, Lymphadenopathy, Leukocytosis, Thr... ORPHA:3392
Immunodeficiency 7
Autoimmune hemolytic anemia, Lymphadenopathy, Splenomegaly, Hypereosinophilia, Neutropenia OMIM:615387
Immunodeficiency 109 With Lymphoproliferation
Generalized lymphadenopathy, Absent circulating B cells, Splenomegaly, Pancytopenia OMIM:620282
Activated Pi3K-Delta Syndrome
Lymphadenopathy, Recurrent tonsillitis, B lymphocytopenia, Arthritis, Splenomegaly ORPHA:397596
Niemann-Pick Disease, Type A
Sea-blue histiocytosis, Lymphadenopathy, Bone-marrow foam cells, Osteoporosis, Splenomegaly, Micr... OMIM:257200
Immunodeficiency With Hyper-Igm, Type 5
Lymphadenopathy OMIM:608106
Immunodeficiency, Common Variable, 2
Follicular hyperplasia, Lymphadenopathy, Splenomegaly, Abnormal T cell count OMIM:240500
Griscelli Syndrome Type 2
Lymphadenopathy, Hemophagocytosis, Pancytopenia, Splenomegaly, Neutropenia ORPHA:79477
Granulomatous Slack Skin
Abnormal lymph node morphology ORPHA:33111
Caspase 8 Deficiency
Lymphadenopathy, Decreased CD4:CD8 ratio, Splenomegaly OMIM:607271
Leishmaniasis
Anemia, Lymphadenopathy, Pancytopenia, Abnormal macrophage morphology, Leukopenia, Splenomegaly, ... ORPHA:507
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Decreased proportion of CD8-positive T cells, Lymphadenopathy, Decreased proportion of CD3-positi... ORPHA:169154
Lymphoproliferative Syndrome 1
Autoimmune hemolytic anemia, Anemia, Hemophagocytosis, Lymphadenopathy, Pancytopenia, Decreased p... OMIM:613011
Combined Immunodeficiency Due To Zap70 Deficiency
Autoimmune hemolytic anemia, Decreased proportion of CD8-positive T cells, Abnormal lymph node mo... ORPHA:911
Felty Syndrome
Anemia, Lymphadenopathy, Arthritis, Abnormal lymphocyte morphology, Limitation of joint mobility,... ORPHA:47612
Tafro Syndrome
Anemia, Lymphadenopathy, Myelofibrosis, Leukocytosis, Thrombocytopenia, Splenomegaly, Hepatosplen... ORPHA:457077
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Autoimmune hemolytic anemia, Lymphadenopathy, Decreased CD4:CD8 ratio, Splenomegaly OMIM:618495
Deafness-Lymphedema-Leukemia Syndrome
Acute leukemia, Abnormal neutrophil count, Lymphadenopathy, Myeloproliferative disorder, Leukocyt... ORPHA:3226
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Lymphoproliferative Syndrome 2
Aplastic anemia, Hemophagocytosis, Lymphadenopathy, Pancytopenia, Hepatosplenomegaly, Splenomegaly OMIM:615122
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Decreased proportion of CD3-positive T cells, Decreased proportion of naive T cells, Decreased pr... ORPHA:276
Classic Mycosis Fungoides
Lymphadenopathy, Abnormal lymphocyte morphology, Splenomegaly ORPHA:2584
Cinca Syndrome
Reduced bone mineral density, Anemia, Lymphadenopathy, Leukocytosis, Abnormal granulocyte morphol... ORPHA:1451
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Acute myeloid leukemia, Normochromic anemia, Chronic lymphatic leukemia, Chron... ORPHA:98849
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Perianal abscess, Lymphadenopathy, Recurrent tonsillitis, Lymphadenitis, Granuloma, Hepatosplenom... OMIM:618935
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Immune Dysregulation, Autoimmunity, And Autoinflammation
Anemia, Cervical lymphadenopathy, Inguinal lymphadenopathy OMIM:620514
Primary Myelofibrosis
Anemia, Lymphadenopathy, Pancytopenia, Extramedullary hematopoiesis, Leukocytosis, Poikilocytosis... ORPHA:824
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Anemia, Lymphadenopathy, Arthritis, Decreased FOXP3-expressing T cell count, Thrombocytopenia, Co... OMIM:304790
Roifman Syndrome
Lymphadenopathy, Delayed proximal femoral epiphyseal ossification, Hip contracture, Hepatosplenom... ORPHA:353298
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Congenital Toxoplasmosis
Thrombocytopenia, Anemia, Lymphadenopathy ORPHA:858
Immunodeficiency 54
Lymphadenopathy, Reduced natural killer cell count, Splenomegaly OMIM:609981
Cyclic Neutropenia
Perianal abscess, Lymphadenopathy, Recurrent tonsillitis, Lymphopenia, Tooth abscess, Thrombocyto... ORPHA:2686
Heme Oxygenase 1 Deficiency
Lymphadenopathy, Asplenia, Coombs-positive hemolytic anemia, Thrombocytosis, Cervical lymphadenop... OMIM:614034
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Osteopenia, Increased B cell count, Absent peripheral lymph nodes in presence of infection, Incre... ORPHA:98813
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Juvenile rheumatoid arthritis, Splenomegaly, Arthritis ORPHA:85414
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly, Hemolytic anemia ORPHA:56425
Aregenerative Anemia
Erythroid hypoplasia, Lymphadenopathy, Pancytopenia, Abnormal proportion of CD8-positive T cells,... ORPHA:101096
Proteasome-Associated Autoinflammatory Syndrome 4
Autoimmune hemolytic anemia, Lymphadenopathy, Flexion contracture, Splenomegaly OMIM:619183
Castleman Disease
Anemia, Mediastinal lymphadenopathy, Lymphadenopathy, Myelofibrosis, Thrombocytopenia, Decreased ... ORPHA:160
Macrophage Activation Syndrome
Anemia, Hemophagocytosis, Abnormal natural killer cell count, Lymphadenopathy, Thrombocytopenia, ... ORPHA:158061
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Autoimmune hemolytic anemia, Lymphadenopathy, Arthritis, Splenomegaly, Lymphopenia, Autoimmune th... OMIM:616100
Omenn Syndrome
Anemia, Lymphadenopathy, B lymphocytopenia, Hypoplasia of the thymus, Severe B lymphocytopenia, T... OMIM:603554
Papa Syndrome
Arthritis, Limitation of joint mobility, Lymphadenopathy ORPHA:69126
Roifman Syndrome
Eosinophilia, Hip contracture, Splenomegaly, Lymphadenopathy OMIM:616651
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy, B lymphocytopenia, Thrombocytopenia, Decreased proportion of memory B cells, Inc... OMIM:618048
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Omenn Syndrome
Anemia, Lymphadenopathy, Abnormal lymphocyte morphology, Leukocytosis, Splenomegaly, Eosinophilia ORPHA:39041
Boutonneuse Fever
Thrombocytopenia, Leukopenia, Lymphadenopathy, Cervical lymphadenopathy ORPHA:83313
Acute Monoblastic/Monocytic Leukemia
Cervical lymphadenopathy, Anemia, Lymphocytosis, Acute monocytic leukemia, Leukocytosis, Hypochro... ORPHA:514
Purine Nucleoside Phosphorylase Deficiency
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Pure red cell ... OMIM:613179
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Liver abscess, Lymphadenopathy, Rectal abscess, Lymphadenitis, Osteomyelitis, Splenomegaly, Impai... OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Liver abscess, Lymphadenopathy, Rectal abscess, Lymphadenitis, Osteomyelitis, Splenomegaly, Impai... OMIM:233710
Rhabdoid Tumor
Thrombocytopenia, Anemia, Lymphadenopathy ORPHA:69077
Griscelli Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Thrombocytopenia, Leukopenia, Splenomegaly, Abnorma... ORPHA:381
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Thymic Neuroendocrine Tumor
Osteopenia, Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy, Neoplasm of the t... ORPHA:97289
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Liver abscess, Lymphadenopathy, Rectal abscess, Lymphadenitis, Osteomyelitis, Splenomegaly, Impai... OMIM:233690
Adult-Onset Still Disease
Anemia, Lymphadenopathy, Arthritis, Leukocytosis, Bone marrow hypocellularity, Arthralgia/arthrit... ORPHA:829
Immunodeficiency, Common Variable, 8, With Autoimmunity
Autoimmune hemolytic anemia, Lymphadenopathy, Pancytopenia, Decreased proportion of class-switche... OMIM:614700
Mixed Connective Tissue Disease
Mediastinal lymphadenopathy, Lymphadenopathy, Arthritis, Joint stiffness, Leukopenia, Splenomegal... ORPHA:809
Sézary Syndrome
Lymphadenopathy, Abnormal lymphocyte morphology, Splenomegaly ORPHA:3162
Proteasome-Associated Autoinflammatory Syndrome 3
Anemia, Lymphadenopathy, Arthritis, Thrombocytopenia, Splenomegaly, Flexion contracture, Lymphopenia OMIM:617591
Desmoplastic Small Round Cell Tumor
Mediastinal lymphadenopathy, Anemia, Lymphadenopathy ORPHA:83469
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Autoimmune hemolytic anemia, Lymphadenopathy, B lymphocytopenia, T lymphocytopenia, Enlarged tons... OMIM:606367
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Lymphadenopathy, Hepatosplenomegaly, Microcytic anemia OMIM:619750
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy, Neutrophilia, Leukocytosis, Increased proportion of CD4-positive T cells OMIM:617099
Diffuse Cutaneous Mastocytosis
Lymphocytosis, Lymphadenopathy, Myeloproliferative disorder, Abnormality of the spleen ORPHA:79456
Acute Promyelocytic Leukemia
Anemia, Lymphadenopathy, Pancytopenia, Leukocytosis, Leukopenia, Thrombocytopenia, Neutropenia ORPHA:520
Immunodeficiency 10
Autoimmune hemolytic anemia, Lymphadenopathy, Abnormal lymphocyte count, Splenomegaly, Autoimmune... OMIM:612783
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Chediak-Higashi Syndrome
Anemia, Hemophagocytosis, Lymphadenopathy, Leukopenia, Splenomegaly, Impaired neutrophil bacteric... OMIM:214500
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Anemia, Lymphadenopathy, Hip osteoarthritis, Knee osteoarthritis, Arthritis, Synovitis, Joint sti... ORPHA:85408
Poems Syndrome
Lymphadenopathy, Sclerosis of hand bone, Sclerosis of foot bone, Polycythemia, Splenomegaly, Scle... ORPHA:2905
Hyper-Igd Syndrome
Lymphadenopathy, Arthritis, Leukocytosis, Lymphadenitis, Neutrophilia, Hepatosplenomegaly, Spleno... OMIM:260920
Acute Generalized Exanthematous Pustulosis
Lymphadenopathy, Leukocytosis, Neutrophilia, Eosinophilia, Neutropenia ORPHA:293173
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Impaired lymphocyte transformation with phytohemagglutinin, Absent peripheral lymph nodes in pres... OMIM:600802
Granulomatous Disease, Chronic, X-Linked
Liver abscess, Lymphadenopathy, Rectal abscess, Lymphadenitis, Granuloma, Osteomyelitis, Splenome... OMIM:306400
Sting-Associated Vasculopathy, Infantile-Onset
Anemia, Joint stiffness, Paratracheal lymphadenopathy, Leukopenia, Lymphopenia, Thrombocytosis, F... OMIM:615934
Immunodeficiency 55
Absent natural killer cells, Neutropenia, Lymphadenopathy, Lymphopenia OMIM:617827
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Autoimmune hemolytic anemia, Lymphadenopathy, Neutropenia in presence of anti-neutropil antibodie... ORPHA:436159
Graft Versus Host Disease
Limited elbow movement, Dupuytren contracture, Lymphadenopathy, Hemophagocytosis, Arthritis, Hepa... ORPHA:39812
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy ORPHA:2221
Lig4 Syndrome
Acute leukemia, Lymphadenopathy, Leukocytosis, Pancytopenia ORPHA:99812
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Anemia, Abnormal natural killer cell count, Pancytopenia, Abnormal lymphocyte count, T lymphocyto... ORPHA:79124
Hemophagocytic Lymphohistiocytosis, Familial, 2
Anemia, Hemophagocytosis, Lymphadenopathy, Pancytopenia, Leukopenia, Splenomegaly, Hepatosplenome... OMIM:603553
Immunodeficiency 31C
Osteopenia, Autoimmune hemolytic anemia, Impaired lymphocyte transformation with phytohemagglutin... OMIM:614162
Hemophagocytic Lymphohistiocytosis, Familial, 1
Anemia, Hemophagocytosis, Lymphadenopathy, Thrombocytopenia, Leukopenia, Splenomegaly OMIM:267700
Familial Hemophagocytic Lymphohistiocytosis
Anemia, Hemophagocytosis, Lymphadenopathy, Thrombocytopenia, Splenomegaly, Neutropenia ORPHA:540
Agammaglobulinemia, X-Linked
Anemia, B lymphocytopenia, T lymphocytopenia, Lymph node hypoplasia, Septic arthritis, Neutropenia OMIM:300755
Nephroblastoma
Lymphadenopathy ORPHA:654
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy, Juvenile rheumatoid arthritis, T lymphocytopenia, Rheumatoid arthritis, Lymphope... OMIM:607944
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Thrombocytopenia, Splenomegaly, Hemolytic anemia ORPHA:169090
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Mevalonic Aciduria
Fluctuating splenomegaly, Anemia, Lymphadenopathy, Leukocytosis, Normocytic hypoplastic anemia, H... OMIM:610377
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Hyperimmunoglobulinemia D With Periodic Fever
Arthritis, Limitation of joint mobility, Lymphadenopathy ORPHA:343
Multiple Myeloma
Osteopenia, Anemia, Lymphadenopathy, Splenomegaly, Pathologic fracture ORPHA:29073
Immunodeficiency With Hyper-Igm, Type 1
Enlarged tonsils, Thrombocytopenia, Splenomegaly, Absence of lymph node germinal center, Hemolyti... OMIM:308230
H Syndrome
Lymphadenopathy, Recurrent fractures, Camptodactyly, Hepatosplenomegaly, Histiocytosis, Microcyti... ORPHA:168569
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Lymphadenopathy, Lymphocytosis, Neutropenia in presence of anti-neut... ORPHA:3261
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy, Arthritis, Lymphopenia, Thrombocytopenia, Leukopenia, Microangiopathic hemolytic... ORPHA:93552
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Farber Disease
Anemia, Lymphadenopathy, Arthritis, Osteoporosis, Thrombocytopenia, Hepatosplenomegaly, Flexion c... ORPHA:333
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly, Arthritis ORPHA:36412
Cutaneous Neuroendocrine Carcinoma
Lymphoid leukemia, Chronic noninfectious lymphadenopathy ORPHA:79140
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Hereditary Amyloidosis With Primary Renal Involvement
Lymphadenopathy, Abnormal lymph node morphology, Hepatosplenomegaly, Anemia ORPHA:85450
Legionnaires Disease
Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy, Lymphopenia ORPHA:549
Drug Reaction With Eosinophilia And Systemic Symptoms
Lymphocytosis, Eosinophilia, Lymphadenopathy ORPHA:139402
Kikuchi-Fujimoto Disease
Anemia, Lymphadenopathy, Abnormal lymph node morphology, Lymphocytosis, Leukopenia, Splenomegaly,... ORPHA:50918
Histiocytosis-Lymphadenopathy Plus Syndrome
Flexion contracture of toe, Lymphadenopathy, Joint contracture of the 5th finger, Elbow flexion c... OMIM:602782
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Anemia, Lymphadenopathy, Lymphadenitis, Leukocytosis, Splenomegaly OMIM:615895
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy, Lymphocytosis, Decreased mean platelet volume, Thrombocytopenia, Cervical lympha... OMIM:617718
Selective Igm Deficiency
Decreased proportion of CD8-positive T cells, Lymphadenopathy, Decreased proportion of CD3-positi... ORPHA:331235
Lymphatic Filariasis
Lymphangiectasis, Lymphadenopathy, Knee osteoarthritis, Abnormality of the lymphatic system, Lymp... ORPHA:2035
Congenital Syphilis
Periostitis, Anemia, Lymphadenopathy, Synovitis, Thrombocytopenia, Hepatosplenomegaly, Extramedul... ORPHA:499009
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Anemia, Lymphadenopathy, Pancytopenia, Arthritis, Leukocytosis, Bone marrow hypocellularity, Leuk... OMIM:615688
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Pancreatoblastoma
Abnormal lymph node morphology ORPHA:677
Chédiak-Higashi Syndrome
Anemia, Hemophagocytosis, Increased proportion of CD25+ mast cells, Pancytopenia, Abnormal natura... ORPHA:167
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly, Lymphopenia, Autoimmune thrombocytopenia, Hemolytic anemia ORPHA:1572
Malt Lymphoma
Mediastinal lymphadenopathy, Anemia, Lymphadenopathy ORPHA:52417
Neuroblastoma
Pathologic fracture, Thrombocytopenia, Anemia, Lymphadenopathy ORPHA:635
Acute Interstitial Pneumonia
Reduced hematocrit, Lymphadenopathy ORPHA:79126
Waldenström Macroglobulinemia
Normocytic anemia, Lymphadenopathy, Splenomegaly, Abnormality of neutrophils, Leukemia ORPHA:33226
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Autoimmune hemolytic anemia, Iron deficiency anemia, Lymphadenopathy, Reduced proportion of CD4-n... ORPHA:37042
Autosomal Recessive Malignant Osteopetrosis
Osteopetrosis, Reduced bone mineral density, Anemia, Lymphadenopathy, Splenomegaly, Craniosynosto... ORPHA:667
Chikungunya
Periostitis, Stiff interphalangeal joints, Lymphadenopathy, Arthritis, Synovitis, Joint stiffness... ORPHA:324625
T-Cell Immunodeficiency With Thymic Aplasia
Lymphadenopathy, Decreased proportion of naive T cells, T lymphocytopenia, Coombs-positive hemoly... ORPHA:83471
Brucellosis
Lung abscess, Liver abscess, Anemia, Lymphadenopathy, Hip osteoarthritis, Knee osteoarthritis, Ar... ORPHA:1304
Immunodeficiency 82 With Systemic Inflammation
Anemia, Lymphadenopathy, B lymphocytopenia, Arthritis, Decreased proportion of naive T cells, T l... OMIM:619381
Q Fever
Anemia, Lymphadenopathy, Granuloma, Hepatosplenomegaly, Splenomegaly, Thrombocytopenia, Osteomyel... ORPHA:781
Idiopathic Hypereosinophilic Syndrome
Anemia, Generalized lymphadenopathy, Arthritis, Myeloproliferative disorder, Myelofibrosis, Leuko... ORPHA:3260
Hennekam Syndrome
Lymphadenopathy, Camptodactyly of finger, Lymphangioma, Splenomegaly, Pulmonary lymphangiectasia,... ORPHA:2136
Carney Triad
Mediastinal lymphadenopathy, Anemia, Lymphadenopathy ORPHA:139411
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Hilar lymph node enlargement, Mediastinal lymphadenopathy, Leukocytosis OMIM:620233
Coccidioidomycosis
Mediastinal lymphadenopathy, Lymphadenopathy, Arthritis, Granuloma, Osteomyelitis, Abnormality of... ORPHA:228123
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Anemia, Lymphadenopathy, Accessory spleen, Splenomegaly, Joint hypermobility, Polysplenia OMIM:619418
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Tangier Disease
Anemia, Chronic noninfectious lymphadenopathy, Orange discolored tonsils, Thrombocytopenia, Hepat... ORPHA:31150
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Leukocytosis, Splenomegaly, Arthritis ORPHA:32960
Familial Pancreatic Carcinoma
Peritoneal abscess, Hepatosplenomegaly, Lymphadenopathy ORPHA:1333
Familial Mediterranean Fever
Lymphadenopathy, Arthritis, Leukocytosis, Osteoarthritis, Splenomegaly ORPHA:342
Sarcoidosis
Anemia, Lymphadenopathy, Abnormal lymph node morphology, Bone cyst, Increased T cell count, Leuko... ORPHA:797
Sarcoidosis, Susceptibility To, 1
Mediastinal lymphadenopathy, Pancytopenia, Bone cyst, Arthritis, Splenomegaly, Generalized lympha... OMIM:181000
Systemic Lupus Erythematosus
Lymphadenopathy, Arthritis, Thrombocytopenia, Leukopenia, Hemolytic anemia ORPHA:536
Primary Sjögren Syndrome
Normocytic anemia, Lymphadenopathy, Normochromic anemia, Arthritis, Decreased proportion of CD4-p... ORPHA:289390
Marburg Hemorrhagic Fever
Lymphadenopathy, Neutrophilia in presence of infection, Arthritis, Abnormal lymphocyte morphology... ORPHA:99826
Lymphangioleiomyomatosis
Abnormality of the lymphatic system, Pulmonary lymphangiomyomatosis, Lymphadenopathy ORPHA:538
Ileal Neuroendocrine Tumor
Lymphadenopathy, Iron deficiency anemia ORPHA:100078
Proteasome-Associated Autoinflammatory Syndrome 1
Flexion contracture of toe, Lymphadenopathy, Elbow flexion contracture, Camptodactyly of finger, ... OMIM:256040
Cushing Syndrome Due To Ectopic Acth Secretion
Abnormal lymph node morphology, Decreased eosinophil count, Leukocytosis, Osteoporosis, Neoplasm ... ORPHA:99889
Crimean-Congo Hemorrhagic Fever
Stiff neck, Lymphadenopathy, Pancytopenia, Leukocytosis, Neutrophilia, Leukopenia, Splenomegaly, ... ORPHA:99827
Igg4-Related Submandibular Gland Disease
Eosinophilia, Lymphadenopathy ORPHA:449432
Blau Syndrome
Anemia, Lymphadenopathy, Limitation of joint mobility, Synovitis, Camptodactyly of finger, Spleno... ORPHA:90340
Behçet Disease
Lymphadenopathy, Splenomegaly, Arthritis ORPHA:117
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Igg4-Related Kidney Disease
Lymphadenitis, Eosinophilia, Lymphadenopathy ORPHA:449395
Igg4-Related Dacryoadenitis And Sialadenitis
Thrombocytopenia, Lymphadenopathy ORPHA:79078
Igg4-Related Ophthalmic Disease
Eosinophilia, Lymphadenopathy ORPHA:449563
Leptospirosis
Thrombocytopenia, Lymphadenopathy ORPHA:509
African Trypanosomiasis
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:3385

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cxcl1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cxcl1.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Activation of the adipocyte CREB/CRTC pathway in obesity. Communications biology (October 2021) Cxcl1em1(IMPC)Mbp PMC8536733

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cxcl1em1(IMPC)Mbp Whole-gene deletion Mice, Tissue

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