Phenotype: shortened RR interval

Definition
reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate
Synonyms
reduced RR interval,  decreased RR interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with shortened RR interval

Total number of significant genotype-phenotype associations: 79

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Gnb2
Gnb2em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.99×10-14
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.58×10-12
Far2
Far2tm2b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.68×10-09
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.00×10-09
Wdr6
Wdr6em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.43×10-09
Phf19
Phf19tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.90×10-08
Ppp2r2b
Ppp2r2btm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 4.14×10-08
Mbd5
Mbd5tm1b(EUCOMM)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR ICS | IMPC 1.09×10-07
H1f10
H1f10tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.46×10-07
D5Ertd579e
D5Ertd579eem1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.46×10-07
Nkg7
Nkg7tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.70×10-07
Hspb1
Hspb1tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.09×10-07
Ppfia3
Ppfia3em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.88×10-07
Ppp1r9b
Ppp1r9btm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.51×10-07
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.48×10-07
C9
C9tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.89×10-07
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.91×10-07
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 9.31×10-07
Wnk2
Wnk2em1Murr
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.48×10-06
Paqr6
Paqr6tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 1.54×10-06
Lin28b
Lin28btm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.08×10-06
Rbm22
Rbm22tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.08×10-06
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.09×10-06
Cbln3
Cbln3tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.22×10-06
Esd
Esdem1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.67×10-06
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HEM Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 3.30×10-06
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.99×10-06
Nox4
Nox4em1(IMPC)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.67×10-06
Dock11
Dock11tm2b(KOMP)Wtsi
HEM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 6.58×10-06
Ccdc30
Ccdc30em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.13×10-06
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.45×10-06
Vsig4
Vsig4tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.93×10-06
Crx
Crxem1(IMPC)Ccpcz
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 9.47×10-06
Hunk
Hunktm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 9.69×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.17×10-05
Pja2
Pja2tm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 1.18×10-05
Cyp4f14
Cyp4f14tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.28×10-05
Nmral1
Nmral1tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.33×10-05
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.47×10-05
Setd3
Setd3tm1.1(NCOM)Mfgc
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 1.51×10-05
Trip13
Trip13tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.57×10-05
Bzw2
Bzw2tm1b(KOMP)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.81×10-05
Csmd3
Csmd3em1(IMPC)Mbp
HOM Late adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.97×10-05
Dnajc28
Dnajc28tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.11×10-05
Rnmt
Rnmttm1b(KOMP)Mbp
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.33×10-05
Cgref1
Cgref1em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.72×10-05
Cnnm2
Cnnm2tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.02×10-05
Asb1
Asb1em1(IMPC)Ccpcz
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 3.03×10-05
Klk8
Klk8em1(IMPC)Ccpcz
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 3.05×10-05
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.27×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 3.47×10-05
Syce1
Syce1tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.71×10-05
Psmc6
Psmc6tm1b(KOMP)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.86×10-05
Spta1
Spta1em1(IMPC)Bay
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.08×10-05
Kctd11
Kctd11em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.25×10-05
Pcdh12
Pcdh12em2(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.67×10-05
Chtf18
Chtf18tm1b(KOMP)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.07×10-05
Lrrc15
Lrrc15tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.18×10-05
Acap1
Acap1tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.30×10-05
Fuca1
Fuca1em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.37×10-05
Fgf9
Fgf9tm1b(KOMP)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.43×10-05
Wdr70
Wdr70em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.69×10-05
Sycp3
Sycp3tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.88×10-05
Rundc3a
Rundc3atm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 6.18×10-05
Asf1b
Asf1bem1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.44×10-05
Chek2
Chek2tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.55×10-05
Herpud2
Herpud2tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 6.73×10-05
Gk2
Gk2em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.09×10-05
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 7.35×10-05
Espnl
Espnltm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.17×10-05
Cbx4
Cbx4tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 8.24×10-05
Rec8
Rec8tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.43×10-05
Fmnl2
Fmnl2em2(IMPC)Tcp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 9.20×10-05
Pax7
Pax7tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 9.46×10-05
Ddx39a
Ddx39atm1b(KOMP)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 9.82×10-05

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 The way we measure

 Phenotype associations stats

1.68% of tested genes with null mutations on a B6N genetic background have a phenotype association to shortened RR interval (74/4397)

0.83% females (36/4351) 0.48% males (21/4341)

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