Gene Summary

Name:
tectonin beta-propeller repeat containing 2
Synonyms:
4930573I19Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
hypoalgesia Tecpr2em1(IMPC)J HOM   Early adult 0.000284 *
increased thermal nociceptive threshold Tecpr2em1(IMPC)J HOM   Early adult 6.19×10-05 *
decreased mechanical nociceptive threshold Tecpr2em1(IMPC)J HOM   Early adult 0.000333 *
hyperactivity Tecpr2em1(IMPC)J HOM   Early adult 2.77×10-14
increased vertical activity Tecpr2em1(IMPC)J HOM Early adult 2.95×10-07

Download data as:  TSV  XLS

* Significant with a threshold of 1x10-3, check the Pain Sensitivity page for more information.
Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes
* Significant with a threshold of 1x10-3, check the Pain Sensitivity page for more information.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

4 Images

X-ray

XRay Images Forepaw

4 Images

X-ray

XRay Images Skull Lateral Orientation

4 Images

X-ray

XRay Images Whole Body Dorso Ventral

4 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

4 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Tecpr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tecpr2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hereditary Sensory And Autonomic Neuropathy Due To Tecpr2 Mutation
Gait ataxia, Dysmetria, Cerebral atrophy, Cerebellar atrophy ORPHA:320385
Neuropathy, Hereditary Sensory And Autonomic, Type Ix, With Developmental Delay
Spastic gait, Gait ataxia, Cerebral atrophy, Dysmetria OMIM:615031

The table below shows human diseases predicted to be associated to Tecpr2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Charcot-Marie-Tooth Disease, Axonal, Type 2S
Gait disturbance, Steppage gait, Axonal degeneration OMIM:616155
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Neurodegeneration Due To Cerebral Folate Transport Deficiency
Neurodegeneration OMIM:613068
Charcot-Marie-Tooth Disease, Axonal, Type 2P
Tip-toe gait, Axonal degeneration, Decreased motor nerve conduction velocity, Peripheral axonal d... OMIM:614436
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Charcot-Marie-Tooth Disease, Dominant Intermediate B
Axonal degeneration, Segmental peripheral demyelination/remyelination, Onion bulb formation, Peri... OMIM:606482
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Charcot-Marie-Tooth Disease, Type 4A
Inability to walk by childhood/adolescence, Decreased sensory nerve conduction velocity, Axonal d... OMIM:214400
Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic lateral sclerosis, Axonal degeneration, Degeneration of anterior horn cells, Peripher... OMIM:602433
Immunodeficiency 8
Hyperactivity OMIM:615401
Diaminopentanuria
Ataxia, Neurodegeneration OMIM:222350
Charcot-Marie-Tooth Disease Type 2B1
Decreased number of large peripheral myelinated nerve fibers, Inability to walk, Axonal degenerat... ORPHA:98856
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Gait disturbance, Decreased number of peripheral myelinated nerve fibers, Degeneration of anterio... OMIM:604484
Charcot-Marie-Tooth Disease, Axonal, Type 2R
Broad-based gait, Inability to walk, Axonal degeneration, Peripheral axonal neuropathy, Decreased... OMIM:615490
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1
Dysmetria, Axonal degeneration, Tip-toe gait, Onion bulb formation, Decreased motor nerve conduct... OMIM:302800
Charcot-Marie-Tooth Disease, Type 4C
Decreased number of large peripheral myelinated nerve fibers, Axonal degeneration, Decreased moto... OMIM:601596
Ceroid Lipofuscinosis, Neuronal, 7
Ataxia, Cerebral atrophy, Neurodegeneration, Optic atrophy, Cerebellar atrophy OMIM:610951
Leukoencephalopathy, Progressive, With Ovarian Failure
Ataxia, Neurodegeneration, Cerebellar atrophy OMIM:615889
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23
Waddling gait, Decreased nerve conduction velocity, Axonal degeneration OMIM:618138
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Ataxia, Cerebral atrophy, Dysmetria, Axonal degeneration, Dysdiadochokinesis, Neurodegeneration, ... OMIM:615157
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Decreased number of large peripheral myelinated nerve fibers, Ataxia, Loss of ambulation, Limb at... OMIM:208920
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity OMIM:616311
Hyperlysinemia, Type I
Hyperactivity OMIM:238700
Mitochondrial Dna Depletion Syndrome 18
Falls, Axonal degeneration OMIM:618811
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity ORPHA:356996
Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Ataxia, Cerebral atrophy, Peripheral hypomyelination, Axonal degeneration, Decreased motor nerve ... OMIM:604168
Neurodegeneration With Brain Iron Accumulation 6
Gait disturbance, Motor axonal neuropathy, Neurodegeneration, Tip-toe gait OMIM:615643
Neuropathy, Hereditary Sensory And Autonomic, Adult-Onset, With Anosmia
Decreased number of peripheral myelinated nerve fibers, Peripheral axonal degeneration, Axonal de... OMIM:608720
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Neurodegeneration, Childhood-Onset, With Brain Atrophy
Ataxia, Cerebral cortical atrophy, Cerebral atrophy, Neurodegeneration, Cerebellar atrophy, Perip... OMIM:617672
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Amyotrophy, Hereditary Neuralgic
Peripheral axonal degeneration, Axonal degeneration OMIM:162100
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 6
Peripheral axonal neuropathy, Axonal degeneration OMIM:620011
Spastic Paraplegia 35, Autosomal Recessive, With Or Without Neurodegeneration
Ataxia, Dysmetria, Dysdiadochokinesis, Neurodegeneration, Atrophy/Degeneration affecting the brai... OMIM:612319
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Gait ataxia, Neurodegeneration, Cerebellar atrophy ORPHA:438134
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Microcephaly, Seizures, And Developmental Delay
Ataxia, Hyperactivity OMIM:613402
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Ataxia, Axonal degeneration, Gait disturbance, Gait ataxia, Abnormal sensory nerve conduction vel... ORPHA:88628
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617182
Insulin-Like Growth Factor I Deficiency
Hyperactivity OMIM:608747
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1
Degeneration of anterior horn cells, Decreased nerve conduction velocity, Peripheral axonal degen... OMIM:604320
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Gait disturbance, Inability to walk, Hyperactivity, Dysmetria OMIM:618090
Combined Oxidative Phosphorylation Defect Type 29
Optic neuropathy, Diffuse cerebellar atrophy, Axonal degeneration, Neurodegeneration, Global brai... ORPHA:478029
Combined Oxidative Phosphorylation Deficiency 29
Optic neuropathy, Axonal degeneration, Optic atrophy, Cerebellar atrophy, Global brain atrophy OMIM:616811
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301008
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Ataxia, Hyperactivity OMIM:617113
Neurodegeneration With Brain Iron Accumulation 5
Cerebral atrophy, Neurodegeneration, Cerebellar atrophy OMIM:300894
Neurodegeneration With Brain Iron Accumulation 2A
Neuronal loss in central nervous system, Ataxia, Cerebral atrophy, Decreased nerve conduction vel... OMIM:256600
Aminoacylase 1 Deficiency
Hyperactivity OMIM:609924
Spastic Paraplegia 79, Autosomal Recessive
Ataxia, Cerebral atrophy, Dysmetria, Neurodegeneration, Optic atrophy, Cerebellar atrophy OMIM:615491
Developmental And Epileptic Encephalopathy 104
Hyperactivity OMIM:619970
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity OMIM:619031
Hyperprolinemia, Type I
Ataxia, Hyperactivity OMIM:239500
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity OMIM:301076
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
De Sanctis-Cacchione Syndrome
Ataxia, Cerebral atrophy, Axonal degeneration, Optic atrophy, Choreoathetosis, Scissor gait, Glob... OMIM:278800
Angioedema, Hereditary, 1
Peripheral axonal neuropathy, Axonal degeneration OMIM:106100
Morm Syndrome
Hyperactivity ORPHA:75858
Krabbe Disease
Decreased nerve conduction velocity, Neurodegeneration, Optic atrophy, Diffuse cerebral atrophy, ... OMIM:245200
Ataxia-Telangiectasia-Like Disorder 2
Ataxia, Unsteady gait, Neurodegeneration, Cerebellar atrophy OMIM:615919
Gm2 Gangliosidosis, Ab Variant
Cerebral atrophy, Neurodegeneration, Exaggerated startle response ORPHA:309246
Encephalopathy, Progressive, With Or Without Lipodystrophy
Ataxia, Hyperactivity OMIM:615924
Adrenomyeloneuropathy
Axonal degeneration, Atrophy/Degeneration involving the corticospinal tracts, Peripheral axonal d... ORPHA:139399
Intellectual Developmental Disorder, Autosomal Dominant 67
Attention deficit hyperactivity disorder, Hyperactivity OMIM:619927
Intellectual Developmental Disorder, Autosomal Recessive 74
Hyperactivity OMIM:617169
Hsd10 Disease, Infantile Type
Loss of ambulation, Cerebral atrophy, Neurodegeneration, Optic atrophy, Diffuse cerebral atrophy,... ORPHA:391428
Juvenile Huntington Disease
Broad-based gait, Ataxia, Progressive cerebellar ataxia, Hyperactivity, Gait ataxia ORPHA:248111
Pyruvate Dehydrogenase E2 Deficiency
Broad-based gait, Difficulty walking, Neurodegeneration, Gait disturbance ORPHA:79244
Gm2-Gangliosidosis, Ab Variant
Cerebral atrophy, Neurodegeneration, Exaggerated startle response OMIM:272750
Neurodegeneration With Brain Iron Accumulation 4
Ataxia, Loss of ambulation, Neurodegeneration, Optic atrophy, Abnormal lower motor neuron morphol... OMIM:614298
Guanidinoacetate Methyltransferase Deficiency
Ataxia, Hyperactivity, Athetosis ORPHA:382
Combined Oxidative Phosphorylation Deficiency 24
Neuronal loss in central nervous system, Neurodegeneration, Optic atrophy, Cerebellar atrophy, Fa... OMIM:616239
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Ataxia, Choreoathetosis, Hyperactivity OMIM:612716
Kanzaki Disease
Cerebral atrophy, Peripheral axonal neuropathy, Axonal degeneration OMIM:609242
Cerebrooculofacioskeletal Syndrome 1
Diffuse cerebral atrophy, Neurodegeneration, Brain atrophy, Cerebellar atrophy OMIM:214150
Neurodegeneration With Brain Iron Accumulation 2B
Cerebral atrophy, Dysmetria, Dysdiadochokinesis, Neurodegeneration, Optic atrophy, Gait ataxia, C... OMIM:610217
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Optic atrophy, Ataxia, Neurodegeneration OMIM:618476
Amyotrophic Lateral Sclerosis
Motor neuron atrophy, Amyotrophic lateral sclerosis, Neurodegeneration ORPHA:803
Neurodegeneration With Brain Iron Accumulation 3
Ataxia, Choreoathetosis, Neurodegeneration OMIM:606159
Cerebrotendinous Xanthomatosis
Optic neuropathy, Ataxia, Decreased nerve conduction velocity, Axonal degeneration, Optic atrophy... ORPHA:909
Adrenoleukodystrophy
Truncal ataxia, Neurodegeneration, Limb ataxia OMIM:300100
Cerebral Visual Impairment
Increased cup-to-disc ratio, Optic nerve hypoplasia, Neurodegeneration, Optic atrophy, Optic disc... ORPHA:447788
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Unsteady gait OMIM:615516
Complex Regional Pain Syndrome
Allodynia ORPHA:83452
Intellectual Developmental Disorder, Autosomal Recessive 71
Attention deficit hyperactivity disorder, Hyperactivity OMIM:618504
Cln5 Disease
Ataxia, Inability to walk, Hyperactivity, Dysmetria, Dysdiadochokinesis, Truncal ataxia, Unsteady... ORPHA:228360
Intellectual Developmental Disorder, X-Linked 107
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301013
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Ataxia, Cerebral atrophy, Neurodegeneration, Optic atrophy, Gait disturbance, Gait ataxia OMIM:616878
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Ataxia, Gait ataxia, Cerebral atrophy, Neurodegeneration OMIM:618321
Trigeminal Neuralgia
Allodynia ORPHA:221091
Chediak-Higashi Syndrome
Gait disturbance, Ataxia, Neurodegeneration, Decreased nerve conduction velocity OMIM:214500
Neurodegeneration With Brain Iron Accumulation 1
Ataxia, Akinesia, Neurodegeneration, Optic atrophy, Gait disturbance, Choreoathetosis, Cerebral d... OMIM:234200
Anterior Cutaneous Nerve Entrapment Syndrome
Allodynia ORPHA:51890
Histidinemia
Hyperactivity ORPHA:2157
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity OMIM:618314
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity ORPHA:85327
Multiple System Atrophy 1, Susceptibility To
Ataxia, Neurodegeneration OMIM:146500
Neurotrophic Keratopathy
Allodynia ORPHA:137596
Mucopolysaccharidosis, Type Ii
Papilledema, Neurodegeneration OMIM:309900
Hyperthyroidism, Nonautoimmune
Hyperactivity OMIM:609152
Mucopolysaccharidosis, Type Vii
Neurodegeneration OMIM:253220
Hereditary Sensory And Autonomic Neuropathy Due To Tecpr2 Mutation
Gait ataxia, Dysmetria, Cerebral atrophy, Cerebellar atrophy ORPHA:320385
Benign Schwannoma
Allodynia ORPHA:252164
Neuropathy, Hereditary Sensory And Autonomic, Type Ix, With Developmental Delay
Spastic gait, Gait ataxia, Cerebral atrophy, Dysmetria OMIM:615031
Hurler Syndrome
Neurodegeneration OMIM:607014
Microcephaly 29, Primary, Autosomal Recessive
Ataxia, Hyperactivity OMIM:620047
Nijmegen Breakage Syndrome
Neurodegeneration OMIM:251260
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Broad-based gait, Ataxia, Tip-toe gait, Neurodegeneration, Falls, Neurofibromas, Peripheral demye... OMIM:619475
Familial Gestational Hyperthyroidism
Hyperactivity ORPHA:99819
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Allodynia OMIM:603041
Primrose Syndrome
Ataxia, Neurodegeneration OMIM:259050

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tecpr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tecpr2.

No publications found that use IMPC mice or data for Tecpr2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Tecpr2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tecpr2em1(IMPC)J Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter