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Phenotype: heart block

Definition
a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart
Synonyms
cardiac conduction block,  cardiac block
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with heart block

Total number of significant genotype-phenotype associations: 54

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Shmt2
Shmt2em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 7.87×10-28
Eral1
Eral1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 3.15×10-19
Eva1a
Eva1aem1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.74×10-13
Usp53
Usp53em1(IMPC)Tcp 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 2.00×10-11
Gba1
Gba1em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.94×10-09
Fbrsl1
Fbrsl1em1(IMPC)Tcp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 5.05×10-09
Slc41a2
Slc41a2em1(IMPC)J 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 6.99×10-09
Ntf5
Ntf5tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 3.34×10-08
Pigq
Pigqtm2b(EUCOMM)Wtsi 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 3.62×10-08
Rab33b
Rab33bem1(IMPC)J 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 9.33×10-08
Cbl
Cbltm1b(EUCOMM)Hmgu 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 9.85×10-08
Gria2
Gria2em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.50×10-07
Ing5
Ing5em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 8.89×10-07
Pcdhb9
Pcdhb9em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.25×10-06
Gde1
Gde1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.39×10-06
Zfp280d
Zfp280dem1(IMPC)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.54×10-06
Pcm1
Pcm1em1(IMPC)Tcp 		HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 1.88×10-06
Ldb3
Ldb3tm2b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.03×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 2.61×10-06
Trmt1
Trmt1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 2.91×10-06
Nsun5
Nsun5tm2b(EUCOMM)Wtsi 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 4.09×10-06
Usp35
Usp35em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 5.75×10-06
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 BCM
IMPC		 9.81×10-06
Chrdl1
Chrdl1em1(IMPC)H 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.05×10-05
Mxd4
Mxd4em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.20×10-05
Psd3
Psd3em1(IMPC)H 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.27×10-05
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.58×10-05
Klf16
Klf16em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.82×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.93×10-05
Setd2
Setd2tm1b(NCOM)Mfgc 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 1.96×10-05
Fbxo42
Fbxo42em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 2.11×10-05
Asxl2
Asxl2tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 2.48×10-05
Gtf2h3
Gtf2h3em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 3.69×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 4.42×10-05
Smim20
Smim20em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 4.67×10-05
Foxo3
Foxo3tm1.1(KOMP)Vlcg 		HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 4.75×10-05
Cct3
Cct3em1(IMPC)Tcp 		HET   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 4.78×10-05
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 5.49×10-05
Hif1an
Hif1anem1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.08×10-05
Il25
Il25em1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.96×10-05
Dusp11
Dusp11tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 6.96×10-05
Synpo2
Synpo2tm1b(EUCOMM)Wtsi 		HET   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 6.97×10-05
Nalf1
Nalf1em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.99×10-05
Pierce2
Pierce2em1(IMPC)H 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 7.20×10-05
Gxylt1
Gxylt1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 7.27×10-05
Eml4
Eml4em1(IMPC)J 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 7.72×10-05
Tmco5
Tmco5tm1b(KOMP)Wtsi 		HOM Late adult prolonged PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 8.40×10-05
Homer2
Homer2em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 8.58×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu 		HET Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 9.76×10-05
Snca
Sncaem1(IMPC)H 		HOM   Late adult prolonged PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.80×10-05
Plce1
Plce1em1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.82×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

0.82% of tested genes with null mutations on a B6N genetic background have a phenotype association to heart block (51/6185)

0.34% females (21/6168) 0.44% males (27/6165)

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