Eye Morphology: Images Ophthalmoscopy

WT Images

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: LEFT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia ; LEFT EYE: A little bit of Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia; LEFT EYE: Slight opacity on lens, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Severe Rd8; LEFT EYE: Slight lens opacity, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

Mutant Images

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina ; LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina ; LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, very slight hemorrhage; RIGHT EYE: Hyaloid present, difficult to focus

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Bright dysplasia and lesion present on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina ; LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE: Crystallized debris

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE: Slight rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing; LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), slight rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity and crystallized debris present (difficult to focus), slight dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina ; LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, no data retina

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; LEFT EYE: Difficult to image and focus.,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, some lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, severe abnormal retinal pigmentation/hemorrhage, moderate rd8; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris (difficut to focus), severe rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight rd8, dysplasia and lens opacity ( difficult to focus).; RIGHT EYE:

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; LEFT EYE: Slight corneal opacity, cotton patch debris, severe dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8; RIGHT EYE: Blood vessel early branching and crossing, some dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia and lens opacity (difficult to focus).; LEFT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE: Some rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia; LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, some corneal opacity (difficult to focus), slight dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, blood vessel crossing, some rd8 and dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia; LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, hyaloid and crystallized debris present. Some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight lens opacity.; RIGHT EYE:

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes some lens opacity, slight hemorrhage; RIGHT EYE: Crystallized debris present, difficult to focus, slight rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; LEFT EYE: Hyaloid present, slight dysplasia, lesion present,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus), slight rd8 ; RIGHT EYE: Slight hemorrhage

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia ; RIGHT EYE: Slight lens opacity, lesion present

58 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia ; LEFT EYE: Thick corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Hyaloid present, slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Thick corneal opacity (difficult to focus and image)

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe dysplasia, a small bright orange spot on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.; LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Small crystallized debris. Some rd8, slight dysplasia and hemorrhaging,
Ophthalmoscope Observation: RIGHT EYE: some lens opacity and some white, cotton debris (difficult to focus). Moderate rd8.

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes slight rd8/dysplasia; RIGHT EYE: Slight lens opacity, crystallized debris, multiple tiny hyaloids present

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Severe rd8, crystallized debris present,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate rd8

57 weeks old

Foxr1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity ; RIGHT EYE: Moderate dysplasia, blood vessel crossing

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