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Gene: Spn MGI:98384

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Gene Summary

Name:
sialophorin
Synonyms:
3E8 antigen,  Ly-48,  Galgp,  A630014B01Rik,  Cd43,  leukosialin,  Ly48

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Spnem1(IMPC)Ics HOM Early adult 5.25×10-11
long tibia Spnem1(IMPC)Ics HOM Early adult 3.00×10-06
increased body length Spnem1(IMPC)Ics HOM Early adult 2.64×10-05
increased cornea thickness Spnem1(IMPC)Ics HOM Early adult 7.72×10-07
abnormal freezing behavior Spnem1(IMPC)Ics HOM Early adult 2.19×10-05
decreased exploration in new environment Spnem1(IMPC)Ics HOM   Early adult 8.20×10-06
abnormal locomotor behavior Spnem1(IMPC)Ics HOM Early adult 1.36×10-05
abnormal behavior Spnem1(IMPC)Ics HOM   Early adult 3.28×10-05
increased total body fat amount Spnem1(IMPC)Ics HOM Early adult 3.00×10-09

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Spn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Spn by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Monocyte Chemotactic Disorder
Cutaneous anergy OMIM:252250
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Autoimmune Disease
Autoimmune antibody positivity, Autoimmunity OMIM:109100
Pa Polymorphism Of Alpha-2-Globulin
Abnormal immunoglobulin level OMIM:260100
Complement Component 4, Partial Deficiency Of
Systemic lupus erythematosus OMIM:120790
Pemphigus Vulgaris, Familial
Autoimmune antibody positivity, Autoimmunity OMIM:169610
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Tn Polyagglutination Syndrome
Autoimmunity OMIM:300622
Hashimoto Thyroiditis
Autoimmune antibody positivity, Hashimoto thyroiditis OMIM:140300
Candidiasis, Familial, 1
Cutaneous anergy OMIM:114580
Immunodeficiency 18
Defective T cell proliferation OMIM:615615
Immunodeficiency 24
Decreased circulating IgG level, Defective T cell proliferation, Reduced antigen-specific T cell ... OMIM:615897
Systemic Lupus Erythematosus 16
Antinuclear antibody positivity, Perinuclear antineutrophil antibody positivity, Anti-dsDNA antib... OMIM:614420
Megalocornea
Iridodonesis, Cataract, Mosaic corneal dystrophy, Deep anterior chamber, Iris transillumination d... OMIM:309300
Brittle Cornea Syndrome 2
Keratoconus, Inguinal hernia, Flat cornea, Sclerocornea, Keratoglobus, Gait disturbance, Decrease... OMIM:614170
Reticular Dysgenesis
Impaired T cell function, Lack of T cell function OMIM:267500
Corneal Dystrophy, Congenital Stromal
Band-shaped corneal dystrophy, Corneal erosion, Increased corneal thickness, Corneal dystrophy OMIM:610048
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Cutaneous anergy OMIM:183350
C1Q Deficiency 1
Autoimmunity, Systemic lupus erythematosus OMIM:613652
Complement Component C1S Deficiency
Hashimoto thyroiditis, Systemic lupus erythematosus OMIM:613783
Immunodeficiency With Hyper-Igm, Type 3
Impaired Ig class switch recombination, Impaired memory B cell generation, Increased circulating ... OMIM:606843
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Depression, Irritability, Tics, Attention ... ORPHA:66624
Immunodeficiency 11A
Agammaglobulinemia, Reduced antigen-specific T cell proliferation, Decreased circulating antibody... OMIM:615206
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Aggressive behavior, Abnormal fear-induced behavior, Pseudobulbar paralysis, Abnormal digit morph... ORPHA:208441
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Decreased circulating IgA level OMIM:235500
Brittle Cornea Syndrome 1
Keratoconus, Congenital hip dislocation, Atypical scarring of skin, Keratoglobus, Disproportionat... OMIM:229200
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Reduced natural killer cell activity OMIM:614493
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Broad-based gait, Anorexia, Aggressive behavior, Abnormal fear-induced behavior, O... ORPHA:3077
Keratoconus 9
Keratoconus, Decreased corneal thickness OMIM:617928
Cornea Plana 2, Autosomal Recessive
Flat cornea, Corneal opacity, Sclerocornea, Corneal arcus, Decreased corneal thickness OMIM:217300
Complement Component 2 Deficiency
Systemic lupus erythematosus OMIM:217000
Corneal Endothelial Dystrophy
Abnormal Descemet membrane morphology, Increased corneal thickness, Corneal dystrophy, Opacificat... OMIM:217700
Metaphyseal Dysostosis-Intellectual Disability-Conductive Deafness Syndrome
Metaphyseal dysplasia, Broad tibial metaphyses, Bowing of the legs, Metaphyseal widening, Flared ... ORPHA:2502
Keratoconus 1
Keratoconus, Astigmatism OMIM:148300
Secondary Non-Traumatic Avascular Necrosis
Autoimmunity, Hematological neoplasm, Systemic lupus erythematosus, Neoplasm, Rheumatoid arthritis ORPHA:399180
Acquired Ichthyosis
Autoimmunity, Lymphoma, Neoplasm, Multiple myeloma, Sarcoma ORPHA:454
Congenital Hereditary Endothelial Dystrophy Type Ii
Increased corneal thickness, Corneal opacity, Abnormal Descemet membrane morphology, Irregular as... ORPHA:293603
Macular Corneal Dystrophy
Hyperopic astigmatism, Corneal crystals, Punctate opacification of the cornea, Recurrent corneal ... ORPHA:98969
Linear Iga Dermatosis
Renal neoplasm, Autoimmunity, Bladder neoplasm ORPHA:46488
Brittle Cornea Syndrome
Hallux valgus, Arachnodactyly, Corneal dystrophy, Corneal erosion, Corneal scarring, Keratoglobus... ORPHA:90354
Immunodeficiency 66
Defective T cell proliferation OMIM:618847
Microtriplication 11Q24.1
Keratoconus, Metatarsus adductus, Small hand, Obesity, Genu valgum, Short foot, Talipes equinovar... ORPHA:289522
Unclassified Myelodysplastic Syndrome
Acute myeloid leukemia, Multiple lineage myelodysplasia, Autoimmunity, Myelodysplasia ORPHA:98827
Griscelli Syndrome, Type 2
Reduced delayed hypersensitivity OMIM:607624
Leber Congenital Amaurosis 7
Keratoconus, Cataract OMIM:613829
Keratoconus 6
Keratoconus OMIM:614623
Keratoconus 5
Keratoconus OMIM:614622
Keratoconus 8
Keratoconus OMIM:614628
Keratoconus 7
Keratoconus OMIM:614629
Spondyloepimetaphyseal Dysplasia, X-Linked
Long fibula, Short palm, Short phalanx of finger, Broad metacarpals, Genu varum, Waddling gait, R... OMIM:300106
Eosinophilopenia
Autoimmunity OMIM:131430
Leber Congenital Amaurosis 2
Keratoconus, Cataract, Eye poking OMIM:204100
Keratoconus Posticus Circumscriptus
Clinodactyly of the 5th finger, Keratoconus, Central posterior corneal opacity, Brachydactyly OMIM:244600
Leber Congenital Amaurosis 6
Keratoconus, Cataract OMIM:613826
Arthrogryposis, Distal, Type 5
Keratoconus, Arachnodactyly, Absent phalangeal crease, Keratoglobus, Distal arthrogryposis, Bilat... OMIM:108145
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Reduced delayed hypersensitivity, Increased circulating IgE level, Increased circulating IgM leve... OMIM:617241
Retinitis Pigmentosa
Atypical scarring of skin, Keratoconus, Cataract, Obesity ORPHA:791
Corneal Dystrophy, Posterior Polymorphous, 3
Keratoconus, Inguinal hernia, Corneal dystrophy, Ectopia pupillae, Corneal guttata OMIM:609141
Immunodeficiency, Common Variable, 2
Partial absence of specific antibody response to unconjugated pneumococcus vaccine, Decreased cir... OMIM:240500
Leber Congenital Amaurosis 1
Keratoconus, Cataract, Eye poking OMIM:204000
Immunodeficiency, Common Variable, 1
Decreased circulating total IgM, Decreased circulating IgG level, Impaired T cell function, Decre... OMIM:607594
Metaphyseal Dysplasia, Braun-Tinschert Type
Broad tibial metaphyses, Humerus varus, Tibial bowing, Exostoses of the ulna, Sclerosis of middle... ORPHA:85188
Leber Congenital Amaurosis 8
Keratoconus, Cataract, Eye poking OMIM:613835
Léri-Weill Dyschondrosteosis
Micromelia, Abnormal tibia morphology, Abnormal carpal morphology, Abnormal femur morphology, Tib... ORPHA:240
Spondylometaphyseal Dysplasia, Sedaghatian Type
Short metacarpal, Cone-shaped metacarpal epiphyses, Iliac crest serration, Widened greater sciati... OMIM:250220
Dermatitis, Atopic
Keratoconus, Cataract, Conjunctivitis OMIM:603165
Hypogonadotropic Hypogonadism-Severe Microcephaly-Sensorineural Hearing Loss-Dysmorphism Syndrome
Overlapping toe, Broad hallux, Genu valgum, Decreased corneal thickness, Contracture of the proxi... ORPHA:293967
Spondyloepimetaphyseal Dysplasia, Missouri Type
Waddling gait, Radial bowing, Rhizomelia, Ulnar bowing, Flared metaphysis, Coxa vara, Tibial bowi... OMIM:602111
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased T cell activation, Decreased specific anti-polysaccharide antibody level, Decreased CD6... OMIM:300853
Leber Congenital Amaurosis 4
Keratoconus OMIM:604393
Edict Syndrome
Keratoconus, Microcornea, Hypoplasia of the iris, Astigmatism, Anterior polar cataract OMIM:614303
Angelman Syndrome
Keratoconus, Hyperactivity, Broad-based gait, Ataxia, Aggressive behavior, Inability to walk, Ton... ORPHA:72
Porphyria Due To Ala Dehydratase Deficiency
Restlessness, Confusion, Ankle flexion contracture, Abnormal fear-induced behavior, Depression, A... ORPHA:100924
Subcorneal Pustular Dermatosis
Rheumatoid arthritis, Autoimmunity, Multiple myeloma, Systemic lupus erythematosus ORPHA:48377
Optic Atrophy-Intellectual Disability Syndrome
Keratoconus, Tapered finger, Repetitive compulsive behavior, Compulsive behaviors, Attention defi... ORPHA:401777
Leber Congenital Amaurosis
Keratoconus, Cataract ORPHA:65
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Increased circulating IgE level, Lack of T cell function ORPHA:277
Immunodeficiency 81
Impaired collagen-induced platelet aggregation, Reduced natural killer cell activity, Reduced ant... OMIM:619374
Pemphigus Erythematosus
Antinuclear antibody positivity, Anti-acetylcholine receptor antibody positivity, Autoimmunity, S... ORPHA:79480
Immunodeficiency With Hyper-Igm, Type 1
Dysgammaglobulinemia, Impaired Ig class switch recombination, Increased circulating IgA level, Im... OMIM:308230
Nail-Patella Syndrome
Keratoconus, Cataract, Glenoid fossa hypoplasia, Patellar aplasia, Hypoplastic radial head, Patel... OMIM:161200
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgA level, Increased circulating IgG level, Increased circulating IgM level... OMIM:601859
Leber Congenital Amaurosis 9
Keratoconus, Eye poking, Macular scar OMIM:608553
Mixed-Type Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia, Lymphoma, Autoimmunity, Systemic lupus erythematosus ORPHA:90036
Immunodeficiency 96
Decreased circulating total IgM, Defective T cell proliferation, Decreased circulating IgG level,... OMIM:619774
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Inguinal hernia, Long fibula, Abnormal metaphysis morphology, Cognitive impairment ORPHA:935
Lacrimoauriculodentodigital Syndrome
Syndactyly, Finger syndactyly, Toe syndactyly, Increased corneal thickness, Abnormal dental ename... ORPHA:2363
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type
Short metacarpal, Broad long bones, Micromelia, Bowing of the legs, Hip subluxation, Metatarsus a... OMIM:271665
Spondyloepimetaphyseal Dysplasia, Genevieve Type
Ataxia, Flared metaphysis, Advanced ossification of carpal bones, Flat acetabular roof, Irregular... OMIM:610442
Autoimmune Hemolytic Anemia, Warm Type
Autoimmune hemolytic anemia, Lymphoproliferative disorder, Autoimmunity, Systemic lupus erythemat... ORPHA:90033
Sjogren Syndrome
Autoimmunity, Rheumatoid arthritis OMIM:270150
Combined Immunodeficiency Due To Partial Rag1 Deficiency
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Autoimmunity ORPHA:231154
Spondylometaphyseal Dysplasia, Sedaghatian Type
Short metacarpal, Iliac crest serration, Metaphyseal chondrodysplasia, Cone-shaped epiphysis, Rhi... ORPHA:93317
Alagille Syndrome
Keratoconus, Hypoplasia of the ulna, Corneal dystrophy, Abnormal pupil morphology, Clinodactyly o... ORPHA:52
Gm2 Gangliosidosis, Ab Variant
Abnormal fear-induced behavior, Inappropriate behavior, Cognitive impairment ORPHA:309246
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Cutaneous anergy, Panhypogammaglobulinemia, Decreased lymphocyte proliferation in response to ant... OMIM:600802
Arterial Tortuosity Syndrome
Keratoconus, Inguinal hernia, Femoral hernia, Arachnodactyly, Rocker bottom foot, Hiatus hernia, ... ORPHA:3342
Warburg-Cinotti Syndrome
Symblepharon, Ankle flexion contracture, Elbow flexion contracture, Osteolytic defects of the pha... OMIM:618175
Costello Syndrome
Keratoconus, Failure to thrive in infancy, Abnormal dental enamel morphology, Ulnar deviation of ... ORPHA:3071
Roifman Syndrome
Decreased T cell activation, Decreased circulating antibody level ORPHA:353298
Autoimmune Lymphoproliferative Syndrome, Type Iia
Increased circulating IgA level, Increased circulating IgG level, Increased circulating IgM level... OMIM:603909
Bare Lymphocyte Syndrome, Type Ii
Agammaglobulinemia, Cutaneous anergy, Panhypogammaglobulinemia OMIM:209920
Gapo Syndrome
Keratoconus, Umbilical hernia, Abnormal pelvic girdle bone morphology, Abnormal metaphysis morpho... ORPHA:2067
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Keratoconus, Failure to thrive, Conjunctivitis OMIM:242150
Arterial Tortuosity Syndrome
Keratoconus, Inguinal hernia, Arachnodactyly, Congenital diaphragmatic hernia, Hiatus hernia, Fle... OMIM:208050
Immunodeficiency By Defective Expression Of Mhc Class Ii
Decreased lymphocyte proliferation in response to mitogen, Panhypogammaglobulinemia, Lack of T ce... ORPHA:572
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Keratoconus, Inguinal hernia, Congenital hip dislocation, Arachnodactyly, Protrusio acetabuli, Mi... OMIM:225400
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Cataract, Broad hallux, Impulsivity, Aggressive behavior, Avascular necrosis of th... ORPHA:353281
Congenital Disorder Of Glycosylation, Type Iil
Decreased specific anti-polysaccharide antibody level, Impaired T cell function OMIM:614576
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Partial IgA deficiency, Lack of T cell function, Decreased circulating total IgM, Decreased lymph... ORPHA:35078
Mental Retardation, Keratoconus, Febrile Seizures, And Sinoatrial Block
Keratoconus OMIM:609438
Orotic Aciduria
Impaired T cell function OMIM:258900
Purine Nucleoside Phosphorylase Deficiency
Abnormality of B cell physiology, Impaired T cell function, Decreased lymphocyte proliferation in... OMIM:613179
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Compulsive behaviors, Abnormal repetitive mannerisms, Syndactyly, Hyperactivity, Broad hallux, Ob... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Compulsive behaviors, Abnormal repetitive mannerisms, Syndactyly, Hyperactivity, Broad hallux, Ob... ORPHA:353277
Hereditary Orotic Aciduria
Impaired T cell function ORPHA:30
Obesity Due To Congenital Leptin Deficiency
Decreased T cell activation ORPHA:66628
Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome
Keratoconus ORPHA:542306
T-Cell Immunodeficiency With Thymic Aplasia
Reduced delayed hypersensitivity OMIM:242700
Obesity Due To Leptin Receptor Gene Deficiency
Decreased T cell activation ORPHA:179494
Gapo Syndrome
Keratoconus, Umbilical hernia, Megalocornea, Shallow anterior chamber OMIM:230740
Schimke Immuno-Osseous Dysplasia
Bone marrow hypocellularity, Impaired T cell function, Abnormal lymphocyte physiology ORPHA:1830
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Impaired T cell function OMIM:201100
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Defective T cell proliferation, Increased circulating IgG level, Decreased T cell activation, Inc... OMIM:618213
Immunodeficiency 58
Decreased specific antibody response to vaccination, Decreased T cell activation, Decreased circu... OMIM:618131
Hypermobile Ehlers-Danlos Syndrome
Keratoconus, Inguinal hernia, Genital hernia, Cystocele, Hip dislocation, Depression, Atypical sc... ORPHA:285
T-Cell Immunodeficiency With Thymic Aplasia
Oligoclonal T cell expansion, Decreased lymphocyte proliferation in response to mitogen ORPHA:83471
Wiskott-Aldrich Syndrome
Reduced natural killer cell activity, Increased circulating IgA level, Increased circulating IgE ... OMIM:301000
Vici Syndrome
Decreased circulating IgG2 level, Cutaneous anergy, Decreased circulating IgG level, Decreased T ... OMIM:242840
Velocardiofacial Syndrome
Impaired T cell function OMIM:192430
Ehlers-Danlos Syndrome, Vascular Type
Keratoconus, Inguinal hernia, Cigarette-paper scars, Cystocele, Foot acroosteolysis, Osteolytic d... OMIM:130050
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Abnormality of T cell physiology ORPHA:2237
Sarcoidosis, Susceptibility To, 1
Abnormality of T cell physiology, Increased circulating antibody level OMIM:181000
Progeroid Short Stature With Pigmented Nevi
Impaired T cell function OMIM:176690
Vascular Ehlers-Danlos Syndrome
Keratoconus, Inguinal hernia, Congenital hip dislocation, Abnormal pupil morphology, Cigarette-pa... ORPHA:286
22Q11.2 Deletion Syndrome
Impaired T cell function ORPHA:567
Digeorge Syndrome
Impaired T cell function OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Spn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Spn.

There are 18 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. Journal of the American Heart Association (July 2021) Spns2tm1c(KOMP)Wtsi PMC8483458
Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. The Journal of biological chemistry (December 2020) Spns2tm1a(KOMP)Wtsi PMC7948482
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Spns2tm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Spns2tm1a(KOMP)Wtsi Spns2tm1b(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Spns2tm1a(KOMP)Wtsi Spns2tm1b(KOMP)Wtsi PMC6459510
Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide. Glia (November 2018) Spns2tm1b(KOMP)Wtsi 30484906
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature communications (October 2017) Spns2tm1b(KOMP)Wtsi PMC5638796
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Spns2tm1a(KOMP)Wtsi PMC5827107
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature (May 2017) Spns2tm1c(KOMP)Wtsi PMC5683179
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature (January 2017) Spns2tm1c(KOMP)Wtsi Spns2tm1a(KOMP)Wtsi PMC5603286
Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. Nature immunology (November 2016) Spns2tm1c(KOMP)Wtsi Spns2tm1a(KOMP)Wtsi PMC5675020
Allele, phenotype and disease data at Mouse Genome Informatics: improving access and analysis. Mammalian genome : official journal of the International Mammalian Genome Society (July 2015) Spns2tm1b(KOMP)Wtsi PMC4534497
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. PLoS genetics (October 2014) Spns2tm1c(KOMP)Wtsi Spns2tm1a(KOMP)Wtsi Spns2tm1b(KOMP)Wtsi PMC4214598
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (July 2013) Spns2tm1a(KOMP)Wtsi PMC3717207
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (November 2012) Spns2tm1a(KOMP)Wtsi PMC3574288
The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Cell reports (October 2012) Spns2tm1c(KOMP)Wtsi Spns2tm1a(KOMP)Wtsi PMC3616498
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS genetics (August 2012) Spns2tm1a(KOMP)Wtsi PMC3410859
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. Journal of immunology (Baltimore, Md. : 1950) (June 2012) Spns2tm1c(KOMP)Wtsi Spns2tm1a(KOMP)Wtsi Spns2tm1b(KOMP)Wtsi PMC3381845

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MGI Allele Allele Type Produced
Spntm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Spnem1(IMPC)Ics Deletion Mice
Spntm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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