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Gene: Zfhx2 MGI:2686934

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Gene Summary

Name:
zinc finger homeobox 2
Synonyms:
zfh-5

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal epididymis morphology Zfhx2em1(IMPC)Rbrc HOM Early adult 0.00
hyperactivity Zfhx2em1(IMPC)Rbrc HOM   Early adult 9.22×10-07
abnormal vertebral arch morphology Zfhx2em1(IMPC)Rbrc HOM Early adult 2.39×10-06
decreased thigmotaxis Zfhx2em1(IMPC)Rbrc HOM   Early adult 9.23×10-05
decreased anxiety-related response Zfhx2em1(IMPC)Rbrc HOM Early adult 3.30×10-07

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Pathology and Tissue Collection

Images

6 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Human diseases caused by Zfhx2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Zfhx2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Marsili Syndrome
OMIM:147430

The table below shows human diseases predicted to be associated to Zfhx2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder, Depression OMIM:613003
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Gilles De La Tourette Syndrome
Compulsive behaviors, Phonic tics, Motor tics, Attention deficit hyperactivity disorder, Self-mut... OMIM:137580
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity, Scoliosis OMIM:616311
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Bruxism, Aggressive behavior OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Bruxism, Aggressive behavior ORPHA:356996
Smith-Magenis syndrome
Hyperactivity, Self-mutilation, Motor stereotypy DECIPHER:8
Pandas
Anorexia, Obsessive-compulsive trait, Irritability, Abnormal fear-induced behavior, Depression, E... ORPHA:66624
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity, Motor stereotypy OMIM:300271
Intellectual Developmental Disorder, X-Linked 109
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... OMIM:309548
Fraxe Intellectual Disability
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... ORPHA:100973
Megalencephalic Leukoencephalopathy With Subcortical Cysts 4, Remitting
Hyperactivity, Dysphagia, Impulsivity OMIM:620448
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity, Self-injurious behavior, Aggressive behavior OMIM:619031
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:301008
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Irritability, Kyphoscoliosis, Abnormal fear-induced behavior, Hyperactivity, Abnormal a... ORPHA:3077
Morm Syndrome
Hyperactivity, Micropenis, Aggressive behavior ORPHA:75858
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Intellectual Developmental Disorder, X-Linked 111
Kyphoscoliosis, Hyperactivity, Compulsive behaviors, Phonic tics, Aggressive behavior OMIM:301107
8p23.1 deletion syndrome
Hyperactivity, Cryptorchidism DECIPHER:39
Developmental And Epileptic Encephalopathy 104
Hyperactivity, Self-injurious behavior, Agitation OMIM:619970
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Glycine Encephalopathy 1
Irritability, Hyperactivity, Impulsivity, Restlessness, Aggressive behavior OMIM:605899
Hartnup Disorder
Hyperactivity, Attention deficit hyperactivity disorder, Emotional lability OMIM:234500
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity, Kyphosis ORPHA:85288
Intellectual Developmental Disorder, X-Linked, Syndromic, Stocco Dos Santos Type
Hyperactivity, Scoliosis, Bruxism, Kyphosis OMIM:300434
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Pseudobulbar paralysis, Abnormal fear-induced behavior, Aggressive behavior ORPHA:208441
Coffin-Siris Syndrome 8
Hyperactivity, Scoliosis, Self-injurious behavior, Cryptorchidism, Aggressive behavior OMIM:618362
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines OMIM:301076
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:617113
Hyperprolinemia, Type I
Hyperactivity, Motor stereotypy, Aggressive behavior OMIM:239500
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity, Depression, Thoracic kyphosis, Compulsive behaviors, Self-injurious behavior, Lumb... OMIM:619467
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Kyphoscoliosis, Motor stereotypy, Aggressive behavior OMIM:615541
Intellectual Developmental Disorder, Autosomal Dominant 67
Hyperactivity, Attention deficit hyperactivity disorder, Compulsive behaviors, Motor tics OMIM:619927
Intellectual Developmental Disorder, Autosomal Recessive 54
Attention deficit hyperactivity disorder, Emotional lability OMIM:617028
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Phenylketonuria
Irritability, Hyperactivity, Depression, Compulsive behaviors, Attention deficit hyperactivity di... OMIM:261600
Fragile X Syndrome
Congenital macroorchidism, Hyperactivity, Macroorchidism, postpubertal, Scoliosis, Recurrent hand... OMIM:300624
Ck Syndrome
Irritability, Hyperactivity, Scoliosis, Hyperlordosis, Kyphosis, Aggressive behavior OMIM:300831
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hyperactivity, Scoliosis, Precocious puberty, Aggressive behavior ORPHA:457260
Lennox-Gastaut Syndrome
Hyperactivity, Irritability, Aggressive behavior ORPHA:2382
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Scoliosis, Frequent temper tantrums, Impulsivity, Motor stereotypy, Attention defi... OMIM:620141
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Compulsive behaviors, Impulsivity, Abnormal eating behavior, Aggressive behavior ORPHA:101039
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Inappropriate behavior, Nail-biting, Hyperactivity, Attention deficit hyperactivity disorder, Sel... OMIM:619827
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Hypospadias, Abnormal testis morphology, Vaginal neoplasm, Abnormality ... ORPHA:1916
Lodder-Merla Syndrome, Type 2, With Developmental Delay And With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Macroorchidism, Aggressive behavior ORPHA:85327
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity, Macroorchidism, Impulsivity OMIM:300143
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Hyperactivity, Motor stereotypy, Self-injurious behavior, Bruxism, Paroxysmal bursts of laughter OMIM:618718
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Recurrent hand flapping, Self-mutilation, Aggressive behavior OMIM:615516
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures
Hyperactivity, Self-injurious behavior, Scoliosis, Aggressive behavior OMIM:620023
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Kyphoscoliosis, Irritability, Hyperactivity, Scoliosis, Motor stereotypy, Aggressive behavior ORPHA:391307
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Hyperactivity, Kyphosis, Impulsivity, Dysphagia, Aggressive behavior ORPHA:500180
Guanidinoacetate Methyltransferase Deficiency
Hyperactivity, Self-injurious behavior, Aggressive behavior ORPHA:382
Intellectual Developmental Disorder, Autosomal Recessive 13
Hyperactivity, Short neck, Bruxism, Recurrent hand flapping OMIM:613192
2Q23.1 Microdeletion Syndrome
Hypoplasia of penis, Hyperactivity, Polyphagia, Motor stereotypy, Self-injurious behavior, Crypto... ORPHA:228402
47,Xyy Syndrome
Hypospadias, Azoospermia, Hyperactivity, Oligozoospermia, Impulsivity, Varicocele, Attention defi... ORPHA:8
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hyperactivity, Scoliosis, Precocious puberty, Aggressive behavior OMIM:300958
Lamb-Shaffer Syndrome
Abnormal temper tantrums, Fused cervical vertebrae, Hyperactivity, Scoliosis, Thoracic kyphosis, ... ORPHA:530983
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Attention deficit hyperactivity disorder, Aggressive behavior OMIM:301013
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Irritability, Hyperactivity, Depression, Scoliosis, Recurrent hand flap... ORPHA:449291
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Scoliosis, Recurrent hand flapping, Motor stereotypy, Attention deficit hyperactiv... OMIM:617600
Graves Disease
Hyperactivity, Irritability, Polyphagia OMIM:275000
Acrodysostosis 2 With Or Without Hormone Resistance
Hyperactivity, Spinal canal stenosis, Cryptorchidism, Hypospadias OMIM:614613
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Hyperactivity, Depression, Dysphoria, Motor stereotypy, Attention deficit hyperactivity disorder,... OMIM:620242
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Low frustration tolerance, Microphallus, Motor stereotypy, Small scrotum, Cryptorc... OMIM:300486
Stankiewicz-Isidor Syndrome
Sacral dimple, Hypospadias, Hyperactivity, Shawl scrotum, Cryptorchidism, Micropenis OMIM:617516
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Abnormal fear-induced behavior ORPHA:309246
Mucopolysaccharidosis, Type Iiic
Beaking of vertebral bodies, Kyphoscoliosis, Hyperactivity, Ovoid thoracolumbar vertebrae, Dysphagia OMIM:252930
Pituitary Adenoma 4, Acth-Secreting
Abnormal fear-induced behavior, Vertebral compression fracture, Emotional lability, Kyphosis, Bic... OMIM:219090
Porphyria Due To Ala Dehydratase Deficiency
Depression, Agitation, Abnormal fear-induced behavior, Restlessness ORPHA:100924
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Attention deficit hyperactivity disorder, Motor stereotypy, Aggressive behavior OMIM:610042
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Self-biting OMIM:618314
Histidinemia
Hyperactivity ORPHA:2157
Floating-Harbor Syndrome
Kyphoscoliosis, Abnormal temper tantrums, Hypospadias, Compulsive behaviors, Impulsivity, Epididy... ORPHA:2044
Familial Gestational Hyperthyroidism
Hyperactivity, Agitation ORPHA:99819
Microcephaly 29, Primary, Autosomal Recessive
Hyperactivity, Emotional lability OMIM:620047
Floating-Harbor Syndrome
Kyphoscoliosis, Hypospadias, Glandular hypospadias, Varicocele, Epididymal cyst, Short neck, Cryp... OMIM:136140
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353281
Myhre Syndrome
Enlarged vertebral pedicles, Platyspondyly, Short neck, Cryptorchidism, Vertebral fusion OMIM:139210
Osteogenesis Imperfecta
Vertebral compression fracture, Enlarged vertebral pedicles, Abnormal form of the vertebral bodie... ORPHA:666
Von Hippel-Lindau Syndrome
Epididymal cyst, Papillary cystadenoma of the epididymis OMIM:193300
Renal Cysts And Diabetes Syndrome
Hypospadias, Bicornuate uterus, Atretic vas deferens, Epididymal cyst, Hypoplasia of the uterus OMIM:137920
Von Hippel-Lindau Disease
Epididymal cyst, Back pain, Papillary cystadenoma of the epididymis ORPHA:892
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear-induced behavior, Hypospadias, Hyperactivity, Emotional lability, Compulsive behavi... ORPHA:353277
Marsili Syndrome
OMIM:147430

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfhx2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfhx2.

No publications found that use IMPC mice or data for Zfhx2.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Zfhx2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zfhx2tm261548(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Zfhx2tm407023(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Zfhx2em1(IMPC)Rbrc Exon Deletion Mice
Zfhx2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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