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Gene: Tm4sf5 MGI:1922854

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Gene Summary

Name:
transmembrane 4 superfamily member 5
Synonyms:
2010003F10Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin coloration Tm4sf5em1(IMPC)Kmpc HOM   Late adult 5.33×10-05
decreased fluid intake Tm4sf5em1(IMPC)Kmpc HOM Early adult 4.85×10-05
increased grip strength Tm4sf5em1(IMPC)Kmpc HOM Early adult 3.44×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Hind Leg and Hip

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Hind Leg and Hip

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Human diseases caused by Tm4sf5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tm4sf5 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hydroxyacyl Glutathione Hydrolase Deficiency
Glyoxalase deficiency OMIM:614033
Lactate Dehydrogenase B Deficiency
Reduced circulating lactate dehydrogenase concentration OMIM:614128
Deoxyribose-5-Phosphate Aldolase Deficiency
Abnormal circulating enzyme concentration or activity OMIM:125460
Hairy Palms And Soles
Hypermelanotic macule OMIM:139650
Hyperpigmentation, Familial Progressive, 1
Hyperpigmentation of the skin OMIM:614233
Nasal Hyperpigmentation, Familial Transverse
Hyperpigmentation of the skin OMIM:161530
Acroleukopathy, Symmetric
Symmetric great toe depigmentation OMIM:102000
Dowling-Degos Disease 1
Progressive reticulate hyperpigmentation OMIM:179850
Lentiginosis, Inherited Patterned
Hypermelanotic macule OMIM:151001
Hyperpigmentation Of Fuldauer And Kuijpers
Hyperpigmentation of the skin OMIM:145200
Linear Atrophoderma Of Moulin
Linear hyperpigmentation ORPHA:140933
Familial Isolated Café-Au-Lait Macules
Freckling, Multiple cafe-au-lait spots ORPHA:2678
Alcohol Sensitivity, Acute
Reduced acetaldehyde dehydrogenase level OMIM:610251
Dowling-Degos Disease 3
Reticulated skin pigmentation, Hyperpigmented/hypopigmented macules OMIM:615674
Acatalasemia
Reduced circulating catalase activity OMIM:614097
Adrenocortical Unresponsiveness To Acth With Postreceptor Defect
Hyperpigmentation of the skin OMIM:202355
Dyschromatosis Symmetrica Hereditaria
Hyperpigmented/hypopigmented macules OMIM:127400
Mediosternal Depigmentation Line
Mediosternal, longitudinal streak of hypopigmentation OMIM:155200
Raindrop Hypopigmentation
Hypopigmentation of the skin OMIM:179500
Dyschromatosis Universalis Hereditaria 1
Hyperpigmented/hypopigmented macules OMIM:127500
Diamond-Blackfan Anemia 17
Hyperpigmentation of the skin OMIM:617409
Angioma, Tufted
Abnormality of skin pigmentation OMIM:607859
Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive
Hypopigmented skin patches, Multiple lentigines, Hypermelanotic macule, Cafe-au-lait spot, Progre... OMIM:145250
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1
Vitiligo OMIM:606579
Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-activating factor acetylhydrolase deficiency OMIM:614278
Hyperbilirubinemia, Rotor Type
Abnormality of skin pigmentation OMIM:237450
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 6
Vitiligo OMIM:193200
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Kleine-Levin Syndrome
Polydipsia, Agitation, Abnormal eating behavior, Polyphagia, Repetitive compulsive behavior, Swee... ORPHA:33543
Autoimmune Disease, Susceptibility To, 1
Vitiligo OMIM:607836
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Hereditary Central Diabetes Insipidus
Polydipsia ORPHA:30925
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Central Diabetes Insipidus
Polydipsia, Anorexia ORPHA:178029
Nephronophthisis 9
Polydipsia OMIM:613824
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Familial Cold Urticaria
Polydipsia ORPHA:47045
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Ochoa Syndrome
Polydipsia ORPHA:2704
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Nephronophthisis 4
Polydipsia OMIM:606966
Cystinosis
Polydipsia, Motor stereotypy ORPHA:213
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia OMIM:304800
Pediatric-Onset Graves Disease
Polydipsia, Polyphagia, Hyperactivity ORPHA:525731
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Nephrogenic Diabetes Insipidus
Polydipsia, Anorexia ORPHA:223
Nephronophthisis 1
Polydipsia OMIM:256100
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Brain-Lung-Thyroid Syndrome
Hyperactivity, Abnormal eating behavior, Compulsive behaviors, Abnormal drinking behavior ORPHA:209905
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Whipple Disease
Polydipsia, Anorexia ORPHA:3452
Nephronophthisis 11
Polydipsia OMIM:613550
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Nephronophthisis 3
Polydipsia OMIM:604387
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia OMIM:617994
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Renal Hypoplasia
Polydipsia ORPHA:93101
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Helix Syndrome
Polydipsia OMIM:617671
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Panhypophysitis
Polydipsia ORPHA:95513
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Gitelman Syndrome
Polydipsia, Salt craving OMIM:263800
Oligomeganephronia
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Rabson-Mendenhall Syndrome
Polydipsia ORPHA:769
Erdheim-Chester Disease
Polydipsia ORPHA:35687
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Polyphagia, Compulsive behaviors, Self-injurious behavior, Aggressive behavior ORPHA:293987
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Hyperparathyroidism-Jaw Tumor Syndrome
Polydipsia, Dysphagia ORPHA:99880
Wolfram Syndrome
Polydipsia ORPHA:3463
Parathyroid Carcinoma
Polydipsia, Dysphagia ORPHA:143
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Gitelman Syndrome
Polydipsia, Salt craving ORPHA:358
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Cystinosis, Nephropathic
Polydipsia, Dysphagia OMIM:219800
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731
Bartter Syndrome, Type 2, Antenatal
Polydipsia OMIM:241200
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tm4sf5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tm4sf5.

No publications found that use IMPC mice or data for Tm4sf5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tm4sf5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Tm4sf5em1(IMPC)Kmpc Deletion Mice
Tm4sf5tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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