Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased thermal nociceptive threshold | Trim14em1(IMPC)Mbp | HOM | Early adult | 0.000254 * |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Trim14 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12Rb1 Deficiency | Recurrent Klebsiella infections, Recurrent candida infections, BCGosis, Coccidioidomycosis, Sever... | ORPHA:319552 | |
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome | Recurrent abscess formation, Abnormal circulating interferon-gamma concentration, Recurrent respi... | ORPHA:79124 | |
Aicardi-Goutieres Syndrome 6 | Increased circulating Interferon-alpha concentration | OMIM:615010 | |
Infection-Related Hemolytic Uremic Syndrome | Increased circulating interleukin 6 concentration, Severe viral infection, Abnormal circulating c... | ORPHA:544482 | |
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome | Abnormal circulating interferon-gamma concentration, Recurrent Aspergillus infections, Recurrent ... | ORPHA:391487 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Trim14em1(IMPC)Mbp | Inter-exon deletion | Mice, Tissue |
Trim14tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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