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Gene: Zfp746 MGI:1916478

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Gene Summary

Name:
zinc finger protein 746
Synonyms:
2810407L07Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal coat/hair pigmentation Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 3.00×10-05
increased total body fat amount Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 1.57×10-13
enlarged seminal vesicle Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 0.00
decreased bone mineral density Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 4.76×10-07
decreased grip strength Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 5.70×10-06
decreased bone mineral content Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 6.27×10-08
increased total body fat amount Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 2.56×10-06
decreased lean body mass Zfp746tm1b(EUCOMM)Hmgu HOM Late adult 8.24×10-08
increased lean body mass Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 1.37×10-08
decreased bone mineral density Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 2.10×10-06

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

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3 Images

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Eye Morphology

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2 Images

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Human diseases caused by Zfp746 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp746 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Griscelli Syndrome, Type 3
Large clumps of pigment irregularly distributed along hair shaft, White eyelashes, Silver-gray hair OMIM:609227
Griscelli Syndrome, Type 1
Silver-gray hair, Melanin pigment aggregation in hair shafts, Hypopigmentation of the skin, Large... OMIM:214450
Osteopathia Striata-Pigmentary Dermopathy-White Forelock Syndrome
White forelock, Coarse metaphyseal trabecularization, Macular hyperpigmented dermopathy ORPHA:2779
Albinism, Oculocutaneous, Type Iii
Albinism, Red hair, Partial albinism OMIM:203290
Tietz Syndrome
White eyebrow, Abnormality of skin pigmentation, Hypopigmentation of the skin, Hypopigmentation o... ORPHA:42665
Hidrotic Ectodermal Dysplasia
Nail dystrophy, Slow-growing nails, Hypopigmentation of hair, Small nail, Absent pubic hair, Hype... ORPHA:189
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Osteoporosis, Albinism, Hypopigmentation of the skin, Hypopigmentation of hair ORPHA:2786
Waardenburg Syndrome, Type 2F
Premature graying of hair, Hypermelanotic macule, Hypopigmentation of the skin, Heterochromia iri... OMIM:619947
Uncombable Hair Syndrome
Abnormal hair morphology, White hair, Patchy alopecia, Woolly hair, Trichodysplasia, Coarse hair ORPHA:1410
Albinism, Oculocutaneous, Type Ib
Albinism, Hypopigmentation of the skin, Hypopigmentation of hair OMIM:606952
Woolly Hair
Hypopigmentation of hair, Brittle hair, Slow-growing hair, Abnormality of hair texture, Woolly ha... ORPHA:170
Congenital Heart Defect-Round Face-Developmental Delay Syndrome
Generalized hyperpigmentation, Hypospadias, Hypopigmentation of hair ORPHA:1355
Griscelli Syndrome, Type 2
Melanin pigment aggregation in hair shafts, Hypopigmentation of the skin, Accumulation of melanos... OMIM:607624
Griscelli Syndrome Type 3
Iris hypopigmentation, Hypopigmentation of hair, Partial albinism ORPHA:79478
Obesity Due To Prohormone Convertase I Deficiency
Childhood-onset truncal obesity, Decreased response to growth hormone stimulation test, Red hair,... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Childhood-onset truncal obesity, Decreased response to growth hormone stimulation test, Red hair,... ORPHA:71526
Primary Immunodeficiency Syndrome Due To Lamtor2 Deficiency
Partial albinism, Hypopigmentation of hair ORPHA:90023
Albinism, Oculocutaneous, Type Iv
Albinism, Blue irides, Hypopigmentation of hair OMIM:606574
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Woolly Hair Nevus
Woolly scalp hair, Heterochromia iridis, Curly hair, Precocious puberty, Congenital posterior occ... ORPHA:79414
Prader-Willi Syndrome Due To Imprinting Mutation
External genital hypoplasia, Hypopigmentation of hair, Hypopigmentation of the skin, Iris hypopig... ORPHA:177910
Waardenburg Syndrome, Type 4B
Hypopigmented skin patches, Premature graying of hair, Heterochromia iridis, White forelock, Whit... OMIM:613265
Waardenburg Syndrome, Type 2A
Premature graying of hair, Numerous pigmented freckles, Heterochromia iridis, Synophrys, White fo... OMIM:193510
Albinism, Oculocutaneous, Type Ii
Red hair, Hypopigmentation of hair, Hypopigmentation of the skin, Albinism, Blue irides, Freckles... OMIM:203200
Oculocutaneous Albinism, Type Viii
Iris transillumination defect, Hypopigmentation of the skin, Hypopigmentation of hair OMIM:619165
Waardenburg Syndrome Type 2
Hypopigmented skin patches, Premature graying of hair, Hypopigmentation of hair, Heterochromia ir... ORPHA:895
Neuroectodermal Melanolysosomal Disease
Premature graying of hair, Generalized hyperpigmentation, Hypopigmentation of the skin, Hypopigme... ORPHA:33445
Acrodysostosis 2 With Or Without Hormone Resistance
Red hair, Hypospadias, Obesity, Advanced ossification of carpal bones, Cryptorchidism, Blue iride... OMIM:614613
Elejalde Neuroectodermal Melanolysosomal Syndrome
Melanin pigment aggregation in hair shafts, Hypopigmentation of the skin, Accumulation of melanos... OMIM:256710
Hypotrichosis 8
Coarse hair, Ridged nail, Sparse scalp hair, Woolly hair, Sparse eyelashes, Nail pits, Sparse eye... OMIM:278150
Piebald Trait-Neurologic Defects Syndrome
Hypopigmented skin patches, Irregular hyperpigmentation, Hypopigmentation of hair, Abnormal eyela... ORPHA:2885
Waardenburg-Shah Syndrome
Premature graying of hair, Hypopigmentation of hair, Synophrys, White forelock, Abnormal eyebrow ... ORPHA:897
Ermine Phenotype
White hair, White eyelashes, Vitiligo, Spotty hyperpigmentation, White eyebrow, Abnormal iris pig... OMIM:227010
Oculocutaneous Albinism Type 3
Blue irides, Red hair, Hypopigmentation of the skin, Iris hypopigmentation, White eyelashes, Whit... ORPHA:79433
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Hypopigmentation of hair, Abnormal eyebrow morphology, Generalized hirsutism, W... ORPHA:2221
Obesity And Hypopigmentation
Obesity, Red hair OMIM:620195
Ataxia-Telangiectasia
Premature graying of hair, Hypopigmentation of hair, Multiple cafe-au-lait spots, Abnormal testis... ORPHA:100
Waardenburg Syndrome Type 1
Premature graying of hair, Hypopigmented skin patches, Hypopigmentation of hair, Abnormal hair mo... ORPHA:894
Sim1-Related Prader-Willi-Like Syndrome
Osteopenia, External genital hypoplasia, Premature pubarche, Hypopigmentation of hair, Small pitu... ORPHA:398079
Piebaldism
Hypopigmented skin patches, Hypopigmentation of hair, Piebald skin depigmentation, Heterochromia ... ORPHA:2884
Oculocutaneous Albinism Type 4
Hypopigmentation of hair, White hair, Hypopigmentation of the skin, Iris hypopigmentation, Abnorm... ORPHA:79435
Hypopigmentation, Organomegaly, And Delayed Myelination And Development
Cafe-au-lait spot, Osteopetrosis, Hypopigmentation of the skin, Hypopigmentation of hair OMIM:618541
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
Hypopigmentation of hair, Alopecia ORPHA:1067
Squalene Synthase Deficiency
Hypospadias, Elbow flexion contracture, Abnormality of hair pigmentation, Bilateral cryptorchidis... OMIM:618156
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Iris hypopigmentation, Obesity, Hypopigmentation of the skin, Hypopigmentation of hair ORPHA:411515
Muenke Syndrome
Hypopigmented skin patches, Hypermelanotic macule, Tarsal synostosis, Hypopigmentation of hair, C... ORPHA:53271
Hermansky-Pudlak Syndrome 3
Albinism, Hypopigmentation of the skin, Hypopigmentation of hair OMIM:614072
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Osteopenia, Decreased response to growth hormone stimulation test, External genital hypoplasia, P... ORPHA:98754
Magel2-Related Prader-Willi-Like Syndrome
Osteopenia, External genital hypoplasia, Premature pubarche, Hypopigmentation of hair, Small pitu... ORPHA:398069
Waardenburg Syndrome, Type 4C
Hypopigmented skin patches, Premature graying of hair, Lacrimal gland hypoplasia, Heterochromia i... OMIM:613266
Congenital Lactic Acidosis, Saguenay-Lac-Saint-Jean Type
Failure to thrive, Abnormal reproductive system morphology, Hypopigmentation of hair ORPHA:70472
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Osteopenia, Decreased response to growth hormone stimulation test, External genital hypoplasia, P... ORPHA:98793
Waardenburg Syndrome
Premature graying of hair, Hypopigmented skin patches, Hypopigmentation of hair, Abnormal vagina ... ORPHA:3440
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Osteopenia, Decreased response to growth hormone stimulation test, External genital hypoplasia, P... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Osteopenia, Decreased response to growth hormone stimulation test, External genital hypoplasia, P... ORPHA:177901
Oculocutaneous Albinism Type 2
Blue irides, Iris transillumination defect, Hypopigmentation of hair, Hyperpigmented nevi, Hypopi... ORPHA:79432
Oculocutaneous Albinism Type 1
Iris transillumination defect, Generalized hypopigmentation, Iris hypopigmentation, White eyelash... ORPHA:352731
Prader-Willi Syndrome
Osteopenia, Decreased response to growth hormone stimulation test, External genital hypoplasia, P... ORPHA:739
Carney Complex, Type 1
Multiple lentigines, Red hair, Pheochromocytoma, Hirsutism, Thyroid follicular hyperplasia, Profu... OMIM:160980
Piebald Trait
Piebald skin depigmentation, Heterochromia iridis, White forelock, Absent pigmentation of the ven... OMIM:172800
Brittle Cornea Syndrome
Abnormality of hair pigmentation, Corneal scarring, Camptodactyly, Osteoporosis, Joint hypermobil... ORPHA:90354
Oculocutaneous Albinism Type 1B
Hypopigmentation of hair, Hypopigmentation of the skin, Iris hypopigmentation, Abnormality of ret... ORPHA:79434
Griscelli Syndrome Type 2
Premature graying of hair, Partial albinism, Iris hypopigmentation, Hypopigmentation of hair ORPHA:79477
Brittle Cornea Syndrome 1
Joint hypermobility, Atypical scarring of skin, Red hair, Dentinogenesis imperfecta OMIM:229200
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Decreased response to growth hormone stimulation test, Red hair, Decreased growth hormone respons... OMIM:609734
Ermine Phenotype
Hypopigmented skin patches, Irregular hyperpigmentation, Hypopigmentation of hair, Iris hypopigme... ORPHA:999
Oculocutaneous Albinism Type 1A
Hypopigmentation of hair, Hypopigmentation of the skin, Iris hypopigmentation, Albinism, Frecklin... ORPHA:79431
Hypohidrotic Ectodermal Dysplasia
Irregular hyperpigmentation, Trichorrhexis nodosa, Breast aplasia, Abnormality of the nail, Abnor... ORPHA:238468
Albinism, Oculocutaneous, Type Ia
Hypopigmentation of hair, Ocular albinism, White hair, Albinism, Blue irides, Absent skin pigment... OMIM:203100
Hermansky-Pudlak Syndrome 1
Hypopigmentation of hair, Hypopigmentation of the skin, Melanocytic nevus, Albinism, Freckling, F... OMIM:203300
Hoyeraal-Hreidarsson Syndrome
Premature graying of hair, Nail dystrophy, Sparse scalp hair, Failure to thrive, Generalized hype... ORPHA:3322
Koolen-De Vries Syndrome
Hypospadias, Hypopigmentation of hair, Abnormal dental enamel morphology, Abnormality of hair tex... ORPHA:96169
Menkes Disease
Tarsal synostosis, Chondrocalcinosis, Hypopigmentation of hair, Inguinal hernia, Woolly hair, Ost... ORPHA:565
Deaf Blind Hypopigmentation Syndrome, Yemenite Type
Hypopigmented skin patches, Hypopigmentation of hair, Hyperpigmentation of the skin, Multiple caf... ORPHA:3214
Classic Phenylketonuria
Hypopigmentation of the skin, Hypopigmentation of hair ORPHA:79254
Angelman Syndrome Due To A Point Mutation
Iris hypopigmentation, Obesity, Hypopigmentation of the skin, Hypopigmentation of hair ORPHA:411511
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Hypopigmentation of hair, Hypopigmentation of the skin, Limitation of movement at ankles, Iris hy... ORPHA:98794
Angelman Syndrome Due To Paternal Uniparental Disomy Of Chromosome 15
Iris hypopigmentation, Hypopigmentation of the skin, Hypopigmentation of hair ORPHA:98795
Oculocerebral Hypopigmentation Syndrome, Cross Type
Hypopigmentation of hair, Inguinal hernia, Limitation of joint mobility, Iris hypopigmentation, C... ORPHA:2719
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Premature graying of hair, Hypopigmented skin patches, Hypopigmentation of hair, Heterochromia ir... ORPHA:163746
Syndromic Diarrhea
Trichorrhexis nodosa, Hypopigmentation of hair, Brittle hair, Inguinal hernia, Generalized hypopi... ORPHA:84064
Hermansky-Pudlak Syndrome
Hypopigmentation of hair, Abnormal dental enamel morphology, Hypopigmentation of the skin, Long e... ORPHA:79430
Autosomal Recessive Faciodigitogenital Syndrome
Dry hair, Hypopigmentation of hair, Joint hypermobility, Shawl scrotum, Coarse hair, Widow's peak ORPHA:1974
Degcags Syndrome
Premature graying of hair, Hypopigmentation of the skin, Low posterior hairline, Abnormal eyebrow... OMIM:619488
Chediak-Higashi Syndrome
Hypopigmentation of hair, Silver-gray hair, Hypopigmentation of the skin, Giant melanosomes in me... OMIM:214500
Prader-Willi Syndrome Due To Translocation
Decreased response to growth hormone stimulation test, External genital hypoplasia, Hypopigmentat... ORPHA:177907
Vici Syndrome
Hypopigmentation of hair, Hypopigmentation of the skin, Failure to thrive, Penile hypospadias, Al... OMIM:242840
Cystinosis, Nephropathic
Rickets, Hypophosphatemic rickets, Hypopigmentation of hair, Hypopigmentation of the skin, Failur... OMIM:219800
Smith-Lemli-Opitz Syndrome
Congenital diaphragmatic hernia, Clitoral hypertrophy, Hypospadias, Hypopigmentation of hair, Hyp... ORPHA:818
Chédiak-Higashi Syndrome
Hypopigmentation of hair, Hypopigmentation of the skin, Large clumps of pigment irregularly distr... ORPHA:167

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp746

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp746.

No publications found that use IMPC mice or data for Zfp746.

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MGI Allele Allele Type Produced
Zfp746tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Zfp746tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Zfp746tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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