MP:0003394 (increased cardiac output) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: increased cardiac output

Definition

greater than normal blood volume pumped by each ventricle per minute

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 7

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Psd3 Psd3^em1(IMPC)H	HOM	Late adult	increased cardiac output	Cardiac Output Echo	MRC Harwell IMPC	6.51×10^-10
Ces1a Ces1a^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	1.24×10^-06
Hycc1 Hycc1^{em1(IMPC)Ccpcz}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	CCP-IMG IMPC	3.88×10^-06
Wdr27 Wdr27^{em1(IMPC)Ccpcz}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	CCP-IMG IMPC	2.24×10^-05
Man2a1 Man2a1^{em1(IMPC)Hmgu}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	HMGU IMPC	3.44×10^-05
Zfp300 Zfp300^em1(IMPC)Bay	HOM	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	4.73×10^-05
Vars2 Vars2^em1(IMPC)Bay	HET	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	6.55×10^-05

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Procedure
Echo

0.37% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac output (7/1898)

0.11% females (2/1882) 0.31% males (5/1600)

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