The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Adrenal gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Aorta | Wholemount images | heterozygote | 100% (2 of 2) |
| Bone | Wholemount images | heterozygote | Ambiguous |
| Brain | Wholemount images | heterozygote | 100% (2 of 2) |
| Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
| Cartilage tissue | Wholemount images | heterozygote | 100% (2 of 2) |
| Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
| Cerebral cortex | Wholemount images | heterozygote | 100% (2 of 2) |
| Esophagus | Wholemount images | heterozygote | 100% (2 of 2) |
| Eye | Wholemount images | heterozygote | 100% (2 of 2) |
| Gall bladder | Wholemount images | heterozygote | 100% (2 of 2) |
| Heart | Wholemount images | heterozygote | 100% (2 of 2) |
| Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
| Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
| Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
| Large intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Liver | Wholemount images | heterozygote | 100% (2 of 2) |
| Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
| Lung | Wholemount images | heterozygote | 100% (2 of 2) |
| Lymph node | Wholemount images | heterozygote | 100% (2 of 2) |
| Mammary gland | Wholemount images | heterozygote | 50% (1 of 2) |
| Olfactory lobe | Wholemount images | heterozygote | 100% (2 of 2) |
| Oral epithelium | Wholemount images | heterozygote | 50% (1 of 2) |
| Ovary | Wholemount images | heterozygote | 50% (1 of 2) |
| Oviduct | Wholemount images | heterozygote | 50% (1 of 2) |
| Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Peripheral nervous system | Wholemount images | heterozygote | 100% (2 of 2) |
| Peyer's patch | Wholemount images | heterozygote | 100% (2 of 2) |
| Pituitary gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Prostate gland | Wholemount images | heterozygote | 50% (1 of 2) |
| Skeletal muscle | Wholemount images | heterozygote | 100% (2 of 2) |
| Skin | Wholemount images | heterozygote | 100% (2 of 2) |
| Small intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
| Stomach | Wholemount images | heterozygote | 100% (2 of 2) |
| Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
| Testis | Wholemount images | heterozygote | 50% (1 of 2) |
| Thymus | Wholemount images | heterozygote | 100% (2 of 2) |
| Thyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Trachea | Wholemount images | heterozygote | 100% (2 of 2) |
| Uterus | Wholemount images | heterozygote | 50% (1 of 2) |
| Vascular system | Wholemount images | heterozygote | 100% (2 of 2) |
| Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
| Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
| Spleen | N/A | heterozygote | 0.0% (0 of 2) |
| White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Brain | N/A | heterozygote | 100% (1 of 1) |
| Brain | N/A | homozygote | 100% (3 of 3) |
| Ear | N/A | heterozygote | 100% (1 of 1) |
| Ear | N/A | homozygote | 33.33% (1 of 3) |
| Embryo | N/A | heterozygote | 100% (1 of 1) |
| Embryo | N/A | homozygote | 100% (3 of 3) |
| Eye | N/A | heterozygote | 100% (1 of 1) |
| Eye | N/A | homozygote | 100% (3 of 3) |
| Footplate | N/A | heterozygote | Ambiguous |
| Footplate | N/A | homozygote | 33.33% (1 of 3) |
| Forebrain | N/A | heterozygote | 100% (1 of 1) |
| Forebrain | N/A | homozygote | 100% (3 of 3) |
| Forelimb | N/A | heterozygote | 100% (1 of 1) |
| Forelimb | N/A | homozygote | 100% (3 of 3) |
| Handplate | N/A | heterozygote | Ambiguous |
| Handplate | N/A | homozygote | 33.33% (1 of 3) |
| Head | N/A | heterozygote | 100% (1 of 1) |
| Head | N/A | homozygote | 100% (3 of 3) |
| Heart | N/A | heterozygote | 100% (1 of 1) |
| Heart | N/A | homozygote | 33.33% (1 of 3) |
| Hindbrain | N/A | heterozygote | 100% (1 of 1) |
| Hindbrain | N/A | homozygote | 100% (3 of 3) |
| Hindlimb | N/A | heterozygote | 100% (1 of 1) |
| Hindlimb | N/A | homozygote | 100% (3 of 3) |
| Liver | N/A | heterozygote | 100% (1 of 1) |
| Liver | N/A | homozygote | 33.33% (1 of 3) |
| Lung | N/A | heterozygote | 100% (1 of 1) |
| Lung | N/A | homozygote | 33.33% (1 of 3) |
| Mandibular process | N/A | heterozygote | 100% (1 of 1) |
| Mandibular process | N/A | homozygote | 33.33% (1 of 3) |
| Maxillary process | N/A | heterozygote | 100% (1 of 1) |
| Maxillary process | N/A | homozygote | 33.33% (1 of 3) |
| Midbrain | N/A | heterozygote | 100% (1 of 1) |
| Midbrain | N/A | homozygote | 100% (3 of 3) |
| Oral cavity | N/A | heterozygote | 100% (1 of 1) |
| Oral cavity | N/A | homozygote | 33.33% (1 of 3) |
| Skin | N/A | heterozygote | 100% (1 of 1) |
| Skin | N/A | homozygote | 33.33% (1 of 3) |
| Tail somite | N/A | heterozygote | 100% (1 of 1) |
| Tail somite | N/A | homozygote | 33.33% (1 of 3) |
| Tail | N/A | heterozygote | 100% (1 of 1) |
| Tail | N/A | homozygote | 100% (3 of 3) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.0% |
| aorta | 0.0% |
| bone | 0.0% |
| brain | 0.0% |
| brainstem | 0.0% |
| brown adipose tissue | 0.0% |
| cartilage tissue | 0.0% |
| cerebellum | 0.0% |
| cerebral cortex | 0.0% |
| esophagus | 0.0% |
| eye | 0.0% |
| gall bladder | 0.0% |
| heart | 0.0% |
| hippocampus | 0.0% |
| hypothalamus | 0.0% |
| kidney | 0.0% |
| large intestine | 0.0% |
| liver | 0.0% |
| lower urinary tract | 0.0% |
| lung | 0.0% |
| lymph node | 0.0% |
| mammary gland | 0.0% |
| olfactory lobe | 0.0% |
| oral epithelium | 0.0% |
| ovary | 0.0% |
| oviduct | 0.0% |
| pancreas | 0.0% |
| parathyroid gland | 0.0% |
| peripheral nervous system | 0.0% |
| peyers patch | 0.0% |
| pituitary gland | 0.0% |
| prostate gland | 0.0% |
| skeletal muscle | 0.0% |
| skin | 0.0% |
| small intestine | 0.0% |
| spinal cord | 0.0% |
| spleen | 0.0% |
| stomach | 0.0% |
| striatum | 0.0% |
| testis | 0.0% |
| thymus | 0.0% |
| thyroid gland | 0.0% |
| trachea | 0.0% |
| uterus | 0.0% |
| vascular system | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| brain | 0.0% |
| ear | 0.0% |
| embryo | 0.0% |
| eye | 0.0% |
| footplate | 0.0% |
| forebrain | 0.0% |
| forelimb | 0.0% |
| handplate | 0.0% |
| head | 0.0% |
| heart | 0.0% |
| hindbrain | 0.0% |
| hindlimb | 0.0% |
| liver | 0.0% |
| lung | 0.0% |
| mandibular process | 0.0% |
| maxillary process | 0.0% |
| midbrain | 0.0% |
| oral cavity | 0.0% |
| skin | 0.0% |
| tail | 0.0% |
| tail somite group | 0.0% |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
M-Mode Images
44 Images
XRay Images Whole Body Dorso Ventral
15 Images
LacZ Images Wholemount
25 Images
XRay Images Forepaw
14 Images
XRay Images Skull Dorso Ventral Orientation
17 Images
XRay Images Skull Lateral Orientation
15 Images
XRay Images Whole Body Lateral Orientation
15 Images
LacZ images wholemount
4 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Usp3.
There are 8 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| MGI Allele | Allele Type | Produced |
|---|---|---|
| Usp3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
| Usp3tm42256(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
| Usp3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
| Usp3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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