Gene: Crispld2 MGI:1926142
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal embryo size | Crispld2tm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
abnormal heart morphology | Crispld2tm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
decreased circulating triglyceride level | Crispld2tm1.1(KOMP)Vlcg | HET | Early adult | 8.52×10-09 | ||
decreased bone mineral density | Crispld2tm1.1(KOMP)Vlcg | HET | Early adult | 3.71×10-07 | ||
prenatal lethality prior to heart atrial septation | Crispld2tm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
preweaning lethality, complete penetrance | Crispld2tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Bone | Section images | heterozygote | 100% (1 of 1) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Heart | Section images | heterozygote | 50% (1 of 2) |
Lung | Section images | heterozygote | 100% (2 of 2) |
Pituitary gland | Section images | heterozygote | 50% (1 of 2) |
Stomach | Section images | heterozygote | 100% (2 of 2) |
Trachea | Section images | heterozygote | 100% (2 of 2) |
Vascular system | Section images | heterozygote | 100% (2 of 2) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 50% (1 of 2) |
Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
Kidney | N/A | heterozygote | 100% (2 of 2) |
Large intestine | N/A | heterozygote | 100% (2 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 50% (1 of 2) |
Oviduct | N/A | heterozygote | 50% (1 of 2) |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | 50% (1 of 2) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | 50% (1 of 2) |
Small intestine | N/A | heterozygote | 100% (2 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
Striatum | N/A | heterozygote | 0.0% (0 of 2) |
Testis | N/A | heterozygote | 0.0% (0 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 50% (1 of 2) |
Tongue | N/A | heterozygote | 100% (1 of 1) |
Uterus | N/A | heterozygote | 50% (1 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | homozygote | 0.0% (0 of 1) |
Brain | N/A | homozygote | 0.0% (0 of 1) |
Central nervous system ganglion | N/A | homozygote | 100% (1 of 1) |
Ear | N/A | homozygote | 0.0% (0 of 1) |
Embryo | N/A | homozygote | 100% (1 of 1) |
Eye | N/A | homozygote | 100% (1 of 1) |
Footplate | N/A | homozygote | 100% (1 of 1) |
Forebrain | N/A | homozygote | 0.0% (0 of 1) |
Forelimb | N/A | homozygote | 100% (1 of 1) |
Gut | N/A | homozygote | 100% (1 of 1) |
Handplate | N/A | homozygote | 0.0% (0 of 1) |
Head | N/A | homozygote | 0.0% (0 of 1) |
Heart | N/A | homozygote | 0.0% (0 of 1) |
Hindbrain | N/A | homozygote | 0.0% (0 of 1) |
Hindlimb | N/A | homozygote | 100% (1 of 1) |
Liver | N/A | homozygote | 100% (1 of 1) |
Lung | N/A | homozygote | 0.0% (0 of 1) |
Mandibular process | N/A | homozygote | 0.0% (0 of 1) |
Maxillary process | N/A | homozygote | 0.0% (0 of 1) |
Midbrain | N/A | homozygote | 0.0% (0 of 1) |
Nose | N/A | homozygote | 100% (1 of 1) |
Oral cavity | N/A | homozygote | 0.0% (0 of 1) |
Skeleton | N/A | homozygote | 0.0% (0 of 1) |
Skin | N/A | homozygote | 0.0% (0 of 1) |
Spinal cord | N/A | homozygote | 0.0% (0 of 1) |
Tail somite | N/A | homozygote | 100% (1 of 1) |
Tail | N/A | homozygote | 0.0% (0 of 1) |
Trachea | N/A | homozygote | 100% (1 of 1) |
Urinary system | N/A | homozygote | 100% (1 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
esophagus | 0.0% |
eye | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
uterus | 0.0% |
vascular system | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
trachea | Ambiguous |
urinary system | Ambiguous |
Human diseases caused by Crispld2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Crispld2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Osteoporosis | Osteoporosis | OMIM:166710 | |
Metaphyseal Modeling Abnormality, Skin Lesions, And Spastic Paraplegia | Increased bone mineral density | OMIM:250500 | |
Hypertriglyceridemia 2 | Hypercholesterolemia, Hypertriglyceridemia | OMIM:619324 | |
Pyknoachondrogenesis | Increased bone mineral density | OMIM:265880 | |
Melorheostosis, Isolated | Hyperostosis, Increased bone mineral density | OMIM:155950 | |
Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hypophosphatemic rickets, Increased bone mineral density, Rickets, Craniosynostosis | OMIM:241520 | |
Dacryocystitis-Osteopoikilosis Syndrome | Increased bone mineral density, Osteopoikilosis | ORPHA:1562 |
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Crispld2
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MGI Allele | Allele Type | Produced |
---|---|---|
Crispld2tm43718(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Crispld2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Crispld2tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Crispld2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
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