Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Cdk8tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
abnormal embryo turning | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal heart morphology | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal freezing behavior | Cdk8tm1b(EUCOMM)Hmgu | HET | Early adult | 6.56×10-05 | ||
decreased exploration in new environment | Cdk8tm1b(EUCOMM)Hmgu | HET | Early adult | 6.48×10-06 | ||
abnormal neural tube closure | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal embryo size | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Cdk8 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities | Ventricular septal defect, Hypoplastic left heart, Tetralogy of Fallot, Patent foramen ovale | OMIM:618748 |
The table below shows human diseases predicted to be associated to Cdk8 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk8.
There are 6 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
The Role of CDKs and CDKIs in Murine Development. | International journal of molecular sciences (July 2020) | Cdk8tm1a(EUCOMM)Hmgu | PMC7432401 |
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. | Development (Cambridge, England) (June 2020) | Cdk8tm1a(EUCOMM)Hmgu | PMC7295591 |
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. | Nature communications (October 2019) | Cdk8tm1c(EUCOMM)Hmgu | PMC6802219 |
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. | Molecular cell (September 2019) | Cdk8tm1c(EUCOMM)Hmgu | 31495563 |
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. | Cell reports (September 2019) | Cdk8tm1a(EUCOMM)Hmgu | 31509750 |
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. | Cancer immunology research (January 2018) | Cdk8tm1c(EUCOMM)Hmgu | 29386186 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Cdk8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Cdk8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Cdk8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
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