Welcome to IMPReSS

International Mouse Phenotyping Resource of Standardised Screens

IMPReSS (International Mouse Phenotyping Resource of Standardised Screens), the successor of EMPReSS, contains standardized phenotyping protocols which are essential for the characterization of mouse phenotypes. IMPReSS contains definitions of the phenotyping Pipelines and mandatory and optional Procedures and Parameters carried out and data collected by international mouse clinics following the protocols defined. This allows data to be comparable and shareable and ontological annotations permit interspecies comparison which may help in the identification of phenotypic mouse-models of human diseases.

The Adult and Embryonic Phenotype Pipeline

The IMPC (International Mouse Phenotyping Consortium) core pipeline describes the phenotype pipeline that has been agreed by the research institutions. The pipeline is currently in development. The protocols in the core IMPC Pipeline are currently being developed by the IMPC phenotyping working groups and the current versions on this site are still under final review. The phenotyping working groups are working closely with the data wranglers to complete an agreed first version. Updates on the progress of this will be available through IMPReSS.

Fertility procedure Viability procedure Gross Morphology Embryo procedure Gross Morphology Placenta procedure MicroCT procedure Viability Secondary Screen procedure Embryo LacZ Gross Morphology Embryo E12.5 Gross Morphology Placenta E12.5 Embryo LacZ Viability E12.5 Secondary Screen Gross Morphology Embryo E14.5-E15.5 Gross Morphology Placenta E14.5-E15.5 MicroCT E14.5-E15.5 Viability E14.5-E15.5 Secondary Screen Gross Morphology Embryo E9.5 Gross Morphology Placenta E9.5 OPT E9.5 Viability E9.5 Secondary Screen Body Weight Open Field Combined SHIRPA and Dysmorphology Grip Strength Light-Dark Test Acoustic Startle and Pre-pulse Inhibition (PPI) Fear Conditioning Indirect Calorimetry Echo Electrocardiogram (ECG) Challenge Whole Body Plethysmography Intraperitoneal glucose tolerance test (IPGTT) X-ray Auditory Brain Stem Response Body Composition (DEXA lean/fat) Eye Morphology Hematology Adult LacZ Clinical Chemistry Insulin Blood Level Immunophenotyping Heart Weight Organ Weight Gross Pathology and Tissue Collection Tissue Embedding and Block Banking Histopathology