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Mouse Phenotyping

The International Mouse Phenotyping Resource of Standardised Screens (IMPReSS) coordinates and presents standardized protocols that are used by the IMPC mouse research clinics to phenotipically assess mutant mouse strains. The focus is on analysing homozygous mutant mice generated on an isogenic C57BL/6N background; when the homozygous results in a lethal phenotype, the heterozygotes are phenotyped. The IMPC phenotyping pipeline (see interactive diagram here) is broad and attempts to reveal insights into human disease by measuring embryonic, neuromuscular, sensory, cardiovascular, metabolic, respiratory, haematological and neurological parameters.

IMPReSS was launched in 2011 and is actively developed. In 2013 the IMPC published the Bloomsbury report on mouse embryo phenotyping, outlining a standard pipeline for the screening of embryonic-lethal knockouts in homozygote mutants.

A bit of  history

IMPReSS is the successor of The European Mouse Phenotyping Resource for Standardized Screens (EMPReSS), which developed more than a 150 standardized protocols for the characterization of mutant mouse strains across European research institutes (the EUMODIC and EUMORPHIA projects). EMPReSS was actively developed from 2002 until it was superseded by IMPReSS in 2011. Phenotype data collected from EMPReSS protocols is available at Europhenome.

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