What is a mouse model?
The genotype-phenotype associations made by the IMPC are used to identify models of human disease based on phenotypic similarity scores (Meehan et al. 2017). Phenodigm scores (Smedley et al. 2013), which capture the similiarity between a knockout mouse and the clinical manifestations (phenotype) of a human disease, are listed in the Gene page. They establish a link between IMPC mouse phenotypes mapped to the Mammalian Phenotype Ontology (MP terms) and the clinical descriptions of human diseases, as featured in OMIM, Orphanet and DECIPHER, described using the Human Phenotype Ontology (Köhler et al. 2017; HP terms). Disease model information is provided in a dedicated section of the Gene page or in the Disease pages.
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