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Phenotype: abnormal KLRG1-positive NK cell number

Definition
deviation in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal KLRG1-positive NK cell number

Total number of significant genotype-phenotype associations: 27

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cnot4
Cnot4tm1b(EUCOMM)Wtsi 		HET Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Fbxw26
Fbxw26tm1b(KOMP)Wtsi 		HOM   Early adult increased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Ifnar1
Ifnar1tm2a(EUCOMM)Wtsi 		HOM Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Ncf2
Ncf2tm1a(EUCOMM)Wtsi 		HOM Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM Early adult increased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Trappc9
Trappc9tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00

Download data as:   TSV   XLS

 The way we measure

Procedure
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

2.95% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal KLRG1-positive NK cell number (14/474)

38.89% females (7/18) 45.00% males (9/20)

Select a parameter    



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