Phenotype: increased heart left ventricle size

Definition
greater than average size of the left ventricle
Synonyms
enlarged left ventricle,  enlarged heart left ventricle
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart left ventricle size

Total number of significant genotype-phenotype associations: 26

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.47×10-11
Erg
Ergem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.51×10-10
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart left ventricle size LVAWd
Echo
MRC Harwell
IMPC
4.53×10-08
Gcdh
Gcdhtm2b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.02×10-07
Oxa1l
Oxa1lem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.33×10-07
Rai2
Rai2em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.46×10-07
Iqcb1
Iqcb1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
3.51×10-07
Slc10a2
Slc10a2tm1b(KOMP)Mbp
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
4.23×10-07
Scn2b
Scn2bem1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
8.11×10-07
Gngt2
Gngt2em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
9.51×10-07
Arhgap24
Arhgap24tm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.49×10-06
Tonsl
Tonslem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.31×10-06
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.60×10-06
Man1b1
Man1b1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.55×10-05
Apol10b
Apol10btm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.99×10-05
Dnd1
Dnd1em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.41×10-05
Slc2a12
Slc2a12em2(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.95×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
3.93×10-05
Col11a1
Col11a1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.32×10-05
Prdm15
Prdm15tm1b(EUCOMM)Wtsi
HET   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.43×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.85×10-05
Skil
Skiltm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
6.22×10-05
Atp1a1
Atp1a1em1(IMPC)Ccpcz
HET Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
6.31×10-05
Btbd8
Btbd8em1(IMPC)Ccpcz
HOM Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
7.61×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.49% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart left ventricle size (24/1606)

0.64% females (10/1566) 0.85% males (11/1293)



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