Phenotype: prolonged QRS complex duration

Definition
increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
widened QRS complex,  prolonged QRS duration,  prolonged QRS interval,  QRS interval elongation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QRS complex duration

Total number of significant genotype-phenotype associations: 33

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Eva1a
Eva1aem1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
9.23×10-14
Gria2
Gria2em1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.12×10-09
Fbrsl1
Fbrsl1em1(IMPC)Tcp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
4.22×10-09
Gba
Gbaem1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.74×10-09
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
3.34×10-08
Slc41a2
Slc41a2em1(IMPC)J
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
6.16×10-08
Gde1
Gde1tm1b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.39×10-06
Chrdl1
Chrdl1em1(IMPC)H
HOM   Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.58×10-06
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.66×10-06
Pcm1
Pcm1em1(IMPC)Tcp
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.62×10-06
Trmt1
Trmt1tm1b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
2.91×10-06
Ldb3
Ldb3tm2b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.10×10-06
Klf16
Klf16em1(IMPC)J
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
8.70×10-06
Psd3
Psd3em1(IMPC)H
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.22×10-06
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
BCM
IMPC
9.81×10-06
Nsun5
Nsun5tm2b(EUCOMM)Wtsi
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.26×10-05
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.58×10-05
Tcea2
Tcea2em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.91×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.93×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
1.96×10-05
Ccpg1os
Ccpg1osem1(IMPC)H
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.45×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
4.12×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
4.42×10-05
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
4.83×10-05
Hif1an
Hif1anem1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
6.08×10-05
Rnf168
Rnf168em1(IMPC)H
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
6.80×10-05
Dusp11
Dusp11tm1b(EUCOMM)Wtsi
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
6.96×10-05
Fam155a
Fam155aem1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
6.99×10-05
Klhdc7b
Klhdc7bem1(IMPC)H
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.54×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu
HET   Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
9.32×10-05
Ing5
Ing5em1(IMPC)J
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
9.49×10-05
Plce1
Plce1em1(IMPC)Mbp
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
9.93×10-05

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 The way we measure

 Phenotype associations stats

0.59% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QRS complex duration (32/5424)

0.19% females (10/5389) 0.30% males (16/5379)

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