Phenotype: decreased heart rate

Definition
fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
bradycardia,  bradyrhythmia,  reduced heart rate
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 111

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Atp2b3
Atp2b3em1(IMPC)J
HOM Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 5.93×10-10
Trh
Trhem1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 5.26×10-09
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 6.27×10-09
Hcn1
Hcn1em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.05×10-08
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.13×10-08
Vgf
Vgfem1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.27×10-08
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.69×10-08
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.06×10-08
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.40×10-08
Atp2b3
Atp2b3em1(IMPC)J
HOM Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.14×10-08
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 5.32×10-08
Prkra
Prkraem1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 7.07×10-08
Gabra2
Gabra2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 8.45×10-08
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.28×10-07
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Echo | HR HMGU | IMPC 1.43×10-07
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.13×10-07
Itga11
Itga11em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.49×10-07
Bmx
Bmxtm1b(EUCOMM)Wtsi
HEM Early adult decreased heart rate Echo | HR ICS | IMPC 5.39×10-07
Pcm1
Pcm1em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 7.85×10-07
Trh
Trhem1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 9.06×10-07
Vgf
Vgfem1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.01×10-06
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.14×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.42×10-06
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.07×10-06
Gabra2
Gabra2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.09×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.13×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.19×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 2.33×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.38×10-06
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 2.38×10-06
Setbp1
Setbp1tm1b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 2.48×10-06
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.72×10-06
Tat
Tatem1(IMPC)J
HOM Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.98×10-06
Grm7
Grm7em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.02×10-06
Tnip1
Tnip1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.22×10-06
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.43×10-06
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 4.62×10-06
Nfix
Nfixem6(IMPC)H
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.88×10-06
Pde2a
Pde2aem1(IMPC)H
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.89×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.46×10-06
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 6.27×10-06
Tbc1d24
Tbc1d24tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 6.32×10-06
Pde2a
Pde2aem1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 7.01×10-06
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 7.45×10-06
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 8.11×10-06
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 8.43×10-06
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 8.52×10-06
Pcm1
Pcm1em1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 8.54×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR CCP-IMG | IMPC 8.85×10-06
Zbtb37
Zbtb37em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 8.88×10-06
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 9.18×10-06
Nbr1
Nbr1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR MRC Harwell | IMPC 1.01×10-05
Ppm1m
Ppm1mtm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.02×10-05
Got1
Got1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.28×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.30×10-05
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.37×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.50×10-05
Itga11
Itga11em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.58×10-05
Spock1
Spock1em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.66×10-05
Tmem203
Tmem203em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.76×10-05
Iho1
Iho1tm2b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.84×10-05
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.06×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.11×10-05
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.18×10-05
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.35×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 2.43×10-05
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.44×10-05
Rps6kc1
Rps6kc1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.46×10-05
Arl5a
Arl5aem1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 2.53×10-05
Ano3
Ano3em2(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.61×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.69×10-05
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 2.77×10-05
Grm7
Grm7em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.84×10-05
Anks1
Anks1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.85×10-05
P3h1
P3h1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 3.09×10-05
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.15×10-05
Ano3
Ano3em2(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.67×10-05
Zbtb37
Zbtb37em1(IMPC)J
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.87×10-05
Fbxw9
Fbxw9tm1a(EUCOMM)Wtsi
HET Early adult decreased heart rate Echo | HR BCM | IMPC 3.98×10-05
Gcsh
Gcshem1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.58×10-05
Tat
Tatem1(IMPC)J
HOM Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 4.72×10-05
Amdhd1
Amdhd1tm2b(EUCOMM)Hmgu
HOM Late adult decreased heart rate Echo | HR MRC Harwell | IMPC 4.91×10-05
Pak2
Pak2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 5.15×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.25×10-05
Tex2
Tex2em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 5.31×10-05
Col9a3
Col9a3em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 5.34×10-05
Tmem203
Tmem203em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.42×10-05
Smo
Smotm1b(KOMP)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 6.63×10-05
Stx6
Stx6em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 7.33×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 7.39×10-05
Dcaf8
Dcaf8em1(IMPC)Ccpcz
HOM Early adult decreased heart rate Echo | HR CCP-IMG | IMPC 7.91×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 7.97×10-05
Prkra
Prkraem1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 8.26×10-05
Col9a3
Col9a3em1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 8.48×10-05
Ubap2l
Ubap2lem1(IMPC)Bay
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.83×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 9.10×10-05
Pla2g4d
Pla2g4dem1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 9.16×10-05
Tnip1
Tnip1tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 9.20×10-05
P4ha3
P4ha3em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 9.41×10-05
Masp1
Masp1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 9.68×10-05
Grp
Grpem1(IMPC)H
HOM Late adult decreased heart rate Echo | HR MRC Harwell | IMPC 9.91×10-05
P3h2
P3h2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 0.000100

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 The way we measure

 Phenotype associations stats

1.33% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (66/4951)

0.45% females (22/4869) 0.68% males (32/4695)

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