Phenotype: decreased fatty acid level

Definition
reduction in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated
Synonyms
lowered fatty acid level,  reduced fatty acid level
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased fatty acid level

Total number of significant genotype-phenotype associations: 82

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 4.57×10-12
Cyb5d1
Cyb5d1tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 1.24×10-11
Dcun1d3
Dcun1d3em1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.67×10-11
Klk14
Klk14tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 4.76×10-11
Cpgi15344
Cpgi15344tm1.1(NCC)WCS
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 9.67×10-11
4930404H24Rik
4930404H24Riktm1a(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.60×10-10
Cpgi5563
Cpgi5563tm1.1(NCC)WCS
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.13×10-09
Kif26b
Kif26btm2b(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 2.29×10-09
Jmjd7
Jmjd7em1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 3.03×10-09
Mindy1
Mindy1tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 6.04×10-09
Rpia
Rpiatm1a(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 9.64×10-09
Acap1
Acap1tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 2.07×10-08
Dclk1
Dclk1tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 3.60×10-08
Polr2f
Polr2ftm1e(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.99×10-08
Hspb3
Hspb3tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 8.37×10-08
Ceacam16
Ceacam16tm1.1(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 1.25×10-07
Cc2d1b
Cc2d1btm1a(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 1.41×10-07
Coq4
Coq4tm1a(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.09×10-07
Cc2d1b
Cc2d1btm1a(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 3.70×10-07
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | MGP 4.21×10-07
C2cd4b
C2cd4bem1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 4.70×10-07
Cd300ld2
Cd300ld2em1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 4.74×10-07
Plcg2
Plcg2Ali14
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid HMGU | EuroPhenome 7.50×10-07
H2bl1
H2bl1tm1b(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.03×10-06
Ift80
Ift80tm1a(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.20×10-06
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 1.28×10-06
Dll1
Dll1m1Mhda
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid HMGU | EuroPhenome 1.39×10-06
Prep
Preptm1b(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 1.80×10-06
Abhd16a
Abhd16atm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.81×10-06
Acbd5
Acbd5tm1b(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.99×10-06
Chn1
Chn1tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 3.90×10-06
Hint1
Hint1tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 4.60×10-06
Cibar1
Cibar1tm1b(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 5.19×10-06
Zdhhc11
Zdhhc11tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 7.07×10-06
Il6ra
Il6raem1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.15×10-06
Rimbp2
Rimbp2em1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.80×10-06
Vamp3
Vamp3tm2b(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.86×10-06
Tpgs2
Tpgs2tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 8.19×10-06
Pdia4
Pdia4tm1b(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 9.32×10-06
Dpy19l3
Dpy19l3tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids ICS | EuroPhenome 9.76×10-06
Usp19
Usp19tm1b(EUCOMM)Hmgu
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.02×10-05
Hyal3
Hyal3tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 1.04×10-05
Plscr2
Plscr2tm1b(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.29×10-05
Hmx3
Hmx3tm1Ebo
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | MGP 1.95×10-05
Ube2d1
Ube2d1tm3e(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.08×10-05
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids HMGU | EuroPhenome 2.65×10-05
Gbp3
Gbp3tm1b(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.76×10-05
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 2.79×10-05
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 2.94×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 3.23×10-05
Cenpo
Cenpotm1b(KOMP)Mbp
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 3.26×10-05
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 3.71×10-05
Osm
Osmtm1b(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 3.88×10-05
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids HMGU | EuroPhenome 3.91×10-05
Emid1
Emid1tm1e(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 4.18×10-05
Mir96
Mir96Dmdo
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids WTSI | MGP 5.90×10-05
Snf8
Snf8tm1a(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | MGP 5.94×10-05
Dnajc28
Dnajc28tm1.1(KOMP)Vlcg
HET Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 5.96×10-05
Mmp8
Mmp8tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 6.00×10-05
Bloc1s2
Bloc1s2tm1.1(KOMP)Mbp
HET Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 6.23×10-05
Krt7
Krt7tm1b(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 6.28×10-05
H2-T24
H2-T24em1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 6.38×10-05
Srrm4
Srrm4tm1e(EUCOMM)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 6.43×10-05
Pus10
Pus10tm1b(EUCOMM)Hmgu
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 6.76×10-05
Rnf169
Rnf169tm1a(EUCOMM)Hmgu
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 6.90×10-05
Thrb
Thrbtm2a(EUCOMM)Wtsi
HOM Early adult decreased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids MRC Harwell | EuroPhenome 7.33×10-05
Slc38a2
Slc38a2tm1a(KOMP)Wtsi
HET Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.71×10-05
Ppp1cc
Ppp1ccem1(IMPC)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 8.41×10-05
Dixdc1
Dixdc1tm1.1(KOMP)Vlcg
HOM Early adult decreased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 8.92×10-05
Esco1
Esco1tm1(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | MGP 9.92×10-05
Gm12253
Gm12253tm1a(KOMP)Wtsi
HOM Early adult decreased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 9.94×10-05

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 The way we measure

 Phenotype associations stats

100.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased fatty acid level (70/70)

36.76% females (25/68) 57.97% males (40/69)

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