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Phenotype: abnormal QRS complex

Definition
anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal QRS complex

Total number of significant genotype-phenotype associations: 63

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Eva1a
Eva1aem1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.74×10-13
Acad11
Acad11em1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.88×10-09
Gba1
Gba1em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.94×10-09
Fbrsl1
Fbrsl1em1(IMPC)Tcp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 4.22×10-09
Slc41a2
Slc41a2em1(IMPC)J 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 6.99×10-09
Ntf5
Ntf5tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 3.34×10-08
Gria2
Gria2em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.50×10-07
Ttc29
Ttc29em1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 2.21×10-07
Ggnbp2
Ggnbp2tm1b(KOMP)Wtsi 		HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 2.62×10-07
Ing5
Ing5em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 6.30×10-07
Pcdhb9
Pcdhb9em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 7.76×10-07
Mgrn1
Mgrn1em1(IMPC)Tcp 		HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 1.06×10-06
Gde1
Gde1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.39×10-06
Zfp280d
Zfp280dem1(IMPC)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.49×10-06
Pcm1
Pcm1em1(IMPC)Tcp 		HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 1.86×10-06
Ldb3
Ldb3tm2b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.03×10-06
Trmt1
Trmt1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 2.91×10-06
Nsun5
Nsun5tm2b(EUCOMM)Wtsi 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.59×10-06
Usp35
Usp35em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 4.41×10-06
Mxd4
Mxd4em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 5.19×10-06
Nxnl2
Nxnl2em1(IMPC)Ccpcz 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 6.72×10-06
Zc3h7b
Zc3h7bem1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 7.53×10-06
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 BCM
IMPC		 9.81×10-06
Nhs
Nhsem1(IMPC)Tcp 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 9.83×10-06
Chrdl1
Chrdl1em1(IMPC)H 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.05×10-05
Psd3
Psd3em1(IMPC)H 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.27×10-05
Fastkd5
Fastkd5em1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.34×10-05
Fbxo42
Fbxo42em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.39×10-05
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.58×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.71×10-05
Klf16
Klf16em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 1.82×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 1.93×10-05
Setd2
Setd2tm1b(NCOM)Mfgc 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 1.96×10-05
Smim20
Smim20em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 2.09×10-05
Thoc6
Thoc6em5(IMPC)Tcp 		HET   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 2.19×10-05
Rbl1
Rbl1tm1b(EUCOMM)Hmgu 		HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 HMGU
IMPC		 2.31×10-05
Asxl2
Asxl2tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 2.48×10-05
Prdm12
Prdm12tm2b(EUCOMM)Hmgu 		HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 2.56×10-05
Rcan3
Rcan3em1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 3.64×10-05
Il25
Il25em1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.68×10-05
Atp1b1
Atp1b1em1(IMPC)Mbp 		HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.14×10-05
Mphosph8
Mphosph8em1(IMPC)J 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 4.27×10-05
Plscr1
Plscr1tm1b(EUCOMM)Hmgu 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 4.37×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 4.42×10-05
Cct3
Cct3em1(IMPC)Tcp 		HET   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 4.56×10-05
Foxo3
Foxo3tm1.1(KOMP)Vlcg 		HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 4.73×10-05
Snx12
Snx12em1(IMPC)J 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 5.35×10-05
Ptp4a2
Ptp4a2em1(IMPC)Tcp 		HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 6.08×10-05
Hif1an
Hif1anem1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.08×10-05
Clcnkb
Clcnkbem1(IMPC)Mbp 		HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.47×10-05
Tagln2
Tagln2em1(IMPC)Tcp 		HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 6.48×10-05
Homer2
Homer2em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 6.72×10-05
Dusp11
Dusp11tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 6.96×10-05
Nalf1
Nalf1em1(IMPC)H 		HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.99×10-05
Pierce2
Pierce2em1(IMPC)H 		HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 7.20×10-05
Pipox
Pipoxtm1b(EUCOMM)Wtsi 		HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 TCP
IMPC		 8.14×10-05
Ecrg4
Ecrg4tm1b(EUCOMM)Hmgu 		HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)		 ICS
IMPC		 8.75×10-05
Adgrg4
Adgrg4em1(IMPC)J 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 9.76×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu 		HET Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 JAX
IMPC		 9.76×10-05
Plce1
Plce1em1(IMPC)Mbp 		HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.83×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

1.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QRS complex (60/6012)

0.52% females (31/5979) 0.40% males (24/5972)

Select a parameter    



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