Phenotype: prolonged QT interval

Definition
increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Synonyms
increased QT interval,  widened QT interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QT interval

Total number of significant genotype-phenotype associations: 21

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
HMGU
IMPC
2.22×10-14
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
ICS
IMPC
3.76×10-10
Dennd5b
Dennd5bem1(IMPC)Tcp
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
7.58×10-09
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
HMGU
IMPC
9.78×10-09
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
HMGU
IMPC
5.09×10-07
Ypel2
Ypel2em1(IMPC)Tcp
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
2.12×10-06
Sun5
Sun5em1(IMPC)Mbp
HOM Late adult prolonged QT interval QT
Electrocardiogram (ECG)
UC Davis
IMPC
3.70×10-06
Col6a3
Col6a3em1(IMPC)Tcp
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
9.44×10-06
Clcf1
Clcf1tm1.1(KOMP)Vlcg
HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
1.35×10-05
Zfp804a
Zfp804aem1(IMPC)Tcp
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
1.41×10-05
Atp13a3
Atp13a3em1(IMPC)J
HOM   Early adult prolonged QT interval QT
Electrocardiogram (ECG)
JAX
IMPC
1.96×10-05
Btnl4
Btnl4em1(IMPC)Tcp
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
2.02×10-05
Cap2
Cap2tm1b(EUCOMM)Wtsi
HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)
HMGU
IMPC
2.11×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
ICS
IMPC
3.76×10-05
Vdac3
Vdac3em1(IMPC)Hmgu
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
HMGU
IMPC
3.89×10-05
Ssh2
Ssh2em1(IMPC)J
HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)
JAX
IMPC
4.03×10-05
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)
ICS
IMPC
4.12×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM   Early adult prolonged QT interval QT
Electrocardiogram (ECG)
CCP-IMG
IMPC
4.32×10-05
Cct3
Cct3em1(IMPC)Tcp
HET   Early adult prolonged QT interval QT
Electrocardiogram (ECG)
TCP
IMPC
6.42×10-05
Klf16
Klf16em1(IMPC)J
HET   Early adult prolonged QT interval QT
Electrocardiogram (ECG)
JAX
IMPC
8.17×10-05
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM   Early adult prolonged QT interval QT
Electrocardiogram (ECG)
ICS
IMPC
9.13×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.60% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QT interval (21/3477)

0.20% females (7/3462) 0.26% males (9/3458)

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