Phenotype: decreased heart weight

Definition
less than average weight of the heart compared to controls
Synonyms
reduced heart weight
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 69

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.32×10-19
Ghrh
Ghrhtm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
9.38×10-19
Gh
Ghtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.89×10-16
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
1.01×10-14
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
7.91×10-14
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.41×10-11
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.55×10-11
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
8.17×10-11
Phex
Phexnot yet available
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
HMGU
EuroPhenome
1.97×10-10
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
WTSI
IMPC
2.70×10-10
Camk1d
Camk1dem1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.86×10-10
Duox2
Duox2em1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
2.71×10-08
Ppp1r12b
Ppp1r12bem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
5.05×10-08
Rnf14
Rnf14em1(IMPC)Ccpcz
HOM Early adult decreased heart weight Heart weight
Heart Weight
CCP-IMG
IMPC
2.27×10-07
Naa10
Naa10em1(IMPC)Mbp
HEM   Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
3.22×10-07
Nucb1
Nucb1em1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.23×10-06
Dytn
Dytnem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
2.70×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
ICS
IMPC
3.07×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
RBRC
IMPC
4.33×10-06
Fbxo11
Fbxo11Jf
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
4.38×10-06
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
6.20×10-06
Exoc3l2
Exoc3l2em1(IMPC)J
HET Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
6.55×10-06
Trh
Trhem1(IMPC)Tcp
HOM   Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
8.45×10-06
Cisd2
Cisd2tm1a(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
9.06×10-06
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
1.04×10-05
Hrh4
Hrh4tm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart weight Heart weight
Heart Weight
ICS
IMPC
1.07×10-05
Ppia
Ppiaem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
1.33×10-05
Rab28
Rab28em1(IMPC)J
HOM   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
1.44×10-05
Mreg
Mregtm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
KMPC
IMPC
1.49×10-05
Atp8b1
Atp8b1em1(IMPC)Tcp
HOM Late adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
1.59×10-05
Fndc3a
Fndc3aem1(IMPC)Tcp
HOM Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
1.60×10-05
Acta2
Acta2em1(IMPC)H
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.05×10-05
Dpp8
Dpp8em1(IMPC)J
HOM   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
2.09×10-05
Coq2
Coq2tm1b(EUCOMM)Hmgu
HET Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.12×10-05
Neurl4
Neurl4em1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.55×10-05
Krt26
Krt26em1(IMPC)KMPC
HOM Late adult decreased heart weight Heart weight
Heart Weight
KMPC
IMPC
2.71×10-05
Tle4
Tle4em1(IMPC)Mbp
HOM   Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.16×10-05
Ythdc2
Ythdc2em1(IMPC)Bay
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
3.42×10-05
Tenm4
Tenm4em1(IMPC)Tcp
HOM Late adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
3.47×10-05
Eif2b5
Eif2b5tm1a(EUCOMM)Wtsi
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
ICS
EuroPhenome
3.66×10-05
Optn
Optntm1a(EUCOMM)Wtsi
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
HMGU
EuroPhenome
4.01×10-05
Mc3r
Mc3rem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
4.06×10-05
Zfp593
Zfp593em1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
4.11×10-05
Fundc1
Fundc1tm1c(KOMP)Wtsi
HEM   Early adult decreased heart weight Heart weight
Heart Weight
WTSI
IMPC
4.25×10-05
Mir96
Mir96Dmdo
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
WTSI
MGP
4.50×10-05
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
MARC
IMPC
4.98×10-05
Nup153
Nup153em1(IMPC)J
HET   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
6.14×10-05
Tmem248
Tmem248tm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
6.15×10-05
Gabrg2
Gabrg2em1(IMPC)Mbp
HET Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
6.23×10-05
1700008P02Rik
1700008P02Rikem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
7.54×10-05
G2e3
G2e3em1(IMPC)Tcp
HOM Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
7.62×10-05
Tram1
Tram1em1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
7.88×10-05
Kctd1
Kctd1em1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
8.40×10-05
Arhgap33
Arhgap33tm1b(KOMP)Wtsi
HET Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
8.58×10-05
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
HMGU
IMPC
8.95×10-05
Mast1
Mast1em1(IMPC)Marc
HOM Early adult decreased heart weight Heart weight
Heart Weight
MARC
IMPC
9.39×10-05
Pcyox1l
Pcyox1lem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
9.78×10-05
Adgrg7
Adgrg7tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
9.83×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (58/7299)

0.27% females (19/7065) 0.59% males (42/7059)

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