Phenotype: increased circulating HDL cholesterol level

Definition
higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 84

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 0.00
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 8.57×10-23
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.78×10-20
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.24×10-15
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.09×10-12
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.25×10-11
Rexo2
Rexo2tm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.31×10-11
Ankrd22
Ankrd22em1(IMPC)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.02×10-10
Nodal
Nodaltm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.17×10-10
Elmod2
Elmod2tm1b(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.20×10-10
Abcg2
Abcg2tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 9.82×10-10
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 3.90×10-09
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.27×10-09
Arrb2
Arrb2tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.43×10-08
Reg3g
Reg3gtm1a(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.67×10-08
Gemin4
Gemin4em1(IMPC)Ics
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.87×10-08
Matn4
Matn4em1(IMPC)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.85×10-08
Skida1
Skida1tm1.1(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.93×10-08
Hdac1
Hdac1tm1a(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 5.79×10-08
Cmpk2
Cmpk2tm1b(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.12×10-08
Cyp7a1
Cyp7a1tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 6.59×10-08
Nat8f2
Nat8f2tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 8.69×10-08
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 9.63×10-08
Sertad3
Sertad3em1(IMPC)Tcp
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 6.69×10-07
Lrba
Lrbaem1(IMPC)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.40×10-07
Btbd9
Btbd9tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 9.61×10-07
D6Wsu163e
D6Wsu163etm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.18×10-06
Snx15
Snx15tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.24×10-06
Kif18b
Kif18btm1a(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.34×10-06
Ptpn23
Ptpn23tm1b(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.35×10-06
Ccl9
Ccl9tm1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.37×10-06
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.39×10-06
Nxn
Nxntm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol CCP-IMG | IMPC 1.54×10-06
Il12a
Il12atm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.55×10-06
Dmap1
Dmap1tm1.1(KOMP)Vlcg
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.56×10-06
Gins3
Gins3em1(IMPC)Tcp
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.61×10-06
Fgf10
Fgf10tm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.78×10-06
Aspm
Aspmtm1a(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.88×10-06
Elk3
Elk3em1(IMPC)Ics
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.96×10-06
Tox3
Tox3tm1b(KOMP)Mbp
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 2.42×10-06
Casq1
Casq1tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 3.12×10-06
Tut4
Tut4tm1a(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.84×10-06
Map3k10
Map3k10tm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 6.52×10-06
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 6.57×10-06
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.93×10-06
Stk16
Stk16tm1.1(KOMP)Vlcg
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 9.24×10-06
Celsr1
Celsr1Scy
HET Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.37×10-06
Slc24a4
Slc24a4tm1b(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.20×10-05
Krit1
Krit1tm1.1(KOMP)Vlcg
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.22×10-05
Otud6a
Otud6atm1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.43×10-05
Ap2a2
Ap2a2em1(IMPC)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.47×10-05
Fbxl22
Fbxl22tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.58×10-05
Pawr
Pawrtm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.65×10-05
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.70×10-05
Tcf7
Tcf7tm1a(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 1.70×10-05
Dnase2b
Dnase2btm1a(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.70×10-05
Gm5155
Gm5155em1(IMPC)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.03×10-05
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.10×10-05
Grm3
Grm3tm1b(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.11×10-05
Acan
Acantm1b(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.12×10-05
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 2.22×10-05
Ube2o
Ube2otm1.1(KOMP)Mbp
HET Early adult increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 2.24×10-05
Ggps1
Ggps1tm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.37×10-05
Pdzk1
Pdzk1tm2b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.43×10-05
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.52×10-05
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.93×10-05
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.93×10-05
Aqp12
Aqp12tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.96×10-05
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.68×10-05
Fpr3
Fpr3tm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.03×10-05
Cul7
Cul7tm1a(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 4.39×10-05
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.53×10-05
Zfp658
Zfp658tm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.81×10-05
Arid3a
Arid3atm1b(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 5.14×10-05
Gckr
Gckrem1(IMPC)H
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.19×10-05
Prkra
Prkraem1(IMPC)H
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.76×10-05
Cdca8
Cdca8tm1a(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | MGP 5.96×10-05
Lhx6
Lhx6tm1b(KOMP)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 6.50×10-05
Il13
Il13tm1.1(KOMP)Vlcg
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 7.12×10-05
Obp2a
Obp2atm1b(EUCOMM)Wtsi
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 7.31×10-05
Runx1t1
Runx1t1tm1b(EUCOMM)Hmgu
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 7.45×10-05
Kdm8
Kdm8tm1b(EUCOMM)Wtsi
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 7.70×10-05
Snx8
Snx8tm2a(EUCOMM)Hmgu
HOM Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.00×10-05
Mettl16
Mettl16tm1b(KOMP)Mbp
HET Early adult increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 9.74×10-05

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 The way we measure

 Phenotype associations stats

2.02% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating HDL cholesterol level (84/4166)

0.18% females (7/3812) 2.02% males (77/3818)

Select a parameter    



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