Phenotype: abnormal heart looping

Definition
any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration
Synonyms
abnormal cardiac looping
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart looping

Total number of significant genotype-phenotype associations: 61

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Aurka
Aurkatm1b(EUCOMM)Hmgu
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Bicc1
Bicc1em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Brap
Brapem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Cad
Cadem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Cubn
Cubntm1b(EUCOMM)Hmgu
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Ddx24
Ddx24em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Dennd1a
Dennd1aem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Eloa
Eloaem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Faf2
Faf2em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Fam32a
Fam32aem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Flnc
Flncem1(IMPC)Bay
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Flnc
Flncem1(IMPC)Bay
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Fuz
Fuzem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Hyls1
Hyls1em1(IMPC)Tcp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping TCP | IMPC 0.00
Ift43
Ift43tm1b(EUCOMM)Hmgu
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Ift52
Ift52em1(IMPC)Bay
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Ift52
Ift52em1(IMPC)Bay
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Ino80b
Ino80btm1b(KOMP)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Kdelr2
Kdelr2em1(IMPC)Bay
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Krit1
Krit1tm1.1(KOMP)Vlcg
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Krit1
Krit1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Lamtor5
Lamtor5tm1b(EUCOMM)Hmgu
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Lss
Lsstm1b(KOMP)Wtsi
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Naa50
Naa50em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Ndufs7
Ndufs7tm1b(EUCOMM)Hmgu
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Nmnat2
Nmnat2em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Nmnat2
Nmnat2em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Nr6a1
Nr6a1tm1b(EUCOMM)Wtsi
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Pcgf1
Pcgf1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Pcnp
Pcnpem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Pcnp
Pcnpem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Pdhb
Pdhbem1(IMPC)Bay
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Pibf1
Pibf1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Pigq
Pigqtm2b(EUCOMM)Wtsi
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Pigq
Pigqtm2b(EUCOMM)Wtsi
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Pkdcc
Pkdccem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Pole2
Pole2em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Rb1cc1
Rb1cc1em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Rgl1
Rgl1em1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Rgl1
Rgl1em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Rprd2
Rprd2em1(IMPC)J
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Slc25a3
Slc25a3tm1b(EUCOMM)Wtsi
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Snapin
Snapintm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Tbx20
Tbx20em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Tedc1
Tedc1em1(IMPC)Tcp
HOM E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping TCP | IMPC 0.00
Thbd
Thbdtm1.1(KOMP)Vlcg
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Ubtf
Ubtfem1(IMPC)Mbp
HET E9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

5.76% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart looping (40/695)

6.99% females (32/458) 5.66% males (25/442)

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter