Phenotype Allele Zygosity Sex Life Stage Procedure Parameter Phenotyping Center Source P Value Data preweaning lethality, incomplete penetrance Aak1 homozygote not_considered Early adult Viability Primary Screen Viability Outcome ICS IMPC 0.0 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_VIA_001_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_VIA_001¶meter_stable_id=IMPC_VIA_001_001&phenotyping_center=ICS abnormal auditory brainstem response Aak1 homozygote not_considered Early adult Auditory Brain Stem Response 24kHz-evoked ABR Threshold ICS IMPC 4.27E-16 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ABR_010_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ABR_002¶meter_stable_id=IMPC_ABR_010_001&phenotyping_center=ICS abnormal auditory brainstem response Aak1 homozygote not_considered Early adult Auditory Brain Stem Response 12kHz-evoked ABR Threshold ICS IMPC 7.23E-16 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ABR_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ABR_002¶meter_stable_id=IMPC_ABR_006_001&phenotyping_center=ICS increased circulating aspartate transaminase level Aak1 homozygote female Early adult Clinical Chemistry Aspartate aminotransferase ICS IMPC 3.45E-15 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_012_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_012_001&phenotyping_center=ICS abnormal auditory brainstem response Aak1 homozygote not_considered Early adult Auditory Brain Stem Response 30kHz-evoked ABR Threshold ICS IMPC 4.81E-15 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ABR_012_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ABR_002¶meter_stable_id=IMPC_ABR_012_001&phenotyping_center=ICS short tibia Aak1 homozygote female Early adult X-ray Tibia length ICS IMPC 4.7E-14 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_XRY_033_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_XRY_001¶meter_stable_id=IMPC_XRY_033_001&phenotyping_center=ICS abnormal auditory brainstem response Aak1 homozygote not_considered Early adult Auditory Brain Stem Response 18kHz-evoked ABR Threshold ICS IMPC 7.08E-14 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ABR_008_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ABR_002¶meter_stable_id=IMPC_ABR_008_001&phenotyping_center=ICS increased vertical activity Aak1 homozygote female Early adult Open Field Number of rears - total ICS IMPC 3.21E-13 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_OFD_021_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_OFD_001¶meter_stable_id=IMPC_OFD_021_001&phenotyping_center=ICS short tibia Aak1 homozygote female Early adult Heart Weight Tibia length ICS IMPC 6.52E-13 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_HWT_002_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HWT_001¶meter_stable_id=IMPC_HWT_002_001&phenotyping_center=ICS increased circulating alkaline phosphatase level Aak1 homozygote female Early adult Clinical Chemistry Alkaline phosphatase ICS IMPC 3.27E-11 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_014_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_014_001&phenotyping_center=ICS abnormal bone structure Aak1 homozygote female Early adult Body Composition (DEXA lean/fat) Bone Area ICS IMPC 3.8E-10 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_DXA_010_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_DXA_001¶meter_stable_id=IMPC_DXA_010_001&phenotyping_center=ICS short tibia Aak1 homozygote male Early adult X-ray Tibia length ICS IMPC 7.3E-9 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_XRY_033_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_XRY_001¶meter_stable_id=IMPC_XRY_033_001&phenotyping_center=ICS increased vertical activity Aak1 homozygote male Early adult Open Field Number of rears - total ICS IMPC 1.19E-8 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_OFD_021_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_OFD_001¶meter_stable_id=IMPC_OFD_021_001&phenotyping_center=ICS short tibia Aak1 homozygote male Early adult Heart Weight Tibia length ICS IMPC 5.42E-8 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_HWT_002_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_HWT_001¶meter_stable_id=IMPC_HWT_002_001&phenotyping_center=ICS decreased startle reflex Aak1 homozygote male Early adult Acoustic Startle and Pre-pulse Inhibition (PPI) Response amplitude - S ICS IMPC 5.19E-7 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ACS_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ACS_003¶meter_stable_id=IMPC_ACS_006_001&phenotyping_center=ICS decreased circulating total protein level Aak1 homozygote male Early adult Clinical Chemistry Total protein ICS IMPC 7.2E-7 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_006_001&phenotyping_center=ICS decreased circulating total protein level Aak1 homozygote female Early adult Clinical Chemistry Total protein ICS IMPC 1.9E-6 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_006_001&phenotyping_center=ICS increased prepulse inhibition Aak1 homozygote male Early adult Acoustic Startle and Pre-pulse Inhibition (PPI) % Pre-pulse inhibition - PPI1 ICS IMPC 3.04E-6 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ACS_033_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ACS_003¶meter_stable_id=IMPC_ACS_033_001&phenotyping_center=ICS decreased grip strength Aak1 homozygote not_considered Early adult Grip Strength Forelimb and hindlimb grip strength measurement mean ICS IMPC 4.91E-6 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_GRS_009_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_GRS_001¶meter_stable_id=IMPC_GRS_009_001&phenotyping_center=ICS increased circulating alkaline phosphatase level Aak1 homozygote male Early adult Clinical Chemistry Alkaline phosphatase ICS IMPC 8.74E-6 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_014_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_014_001&phenotyping_center=ICS abnormal contextual conditioning behavior Aak1 homozygote not_considered Early adult Fear Conditioning Context freezing total ICS IMPC 3.39E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=ICS_FEA_005_001&pipeline_stable_id=ICS_001&procedure_stable_id=ICS_FEA_001¶meter_stable_id=ICS_FEA_005_001&phenotyping_center=ICS abnormal heart left ventricle morphology Aak1 homozygote not_considered Early adult Echo LVIDd ICS IMPC 3.41E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_ECH_008_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_ECH_001¶meter_stable_id=IMPC_ECH_008_001&phenotyping_center=ICS hyperactivity Aak1 homozygote not_considered Early adult Open Field Periphery average speed ICS IMPC 3.54E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_OFD_013_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_OFD_001¶meter_stable_id=IMPC_OFD_013_001&phenotyping_center=ICS abnormal contextual conditioning behavior Aak1 homozygote not_considered Early adult Fear Conditioning % Context freezing total ICS IMPC 3.57E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=ICS_FEA_009_001&pipeline_stable_id=ICS_001&procedure_stable_id=ICS_FEA_001¶meter_stable_id=ICS_FEA_009_001&phenotyping_center=ICS decreased circulating serum albumin level Aak1 homozygote male Early adult Clinical Chemistry Albumin ICS IMPC 4.81E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_007_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_007_001&phenotyping_center=ICS increased circulating alanine transaminase level Aak1 homozygote female Early adult Clinical Chemistry Alanine aminotransferase ICS IMPC 5.01E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_013_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_013_001&phenotyping_center=ICS decreased circulating cholesterol level Aak1 homozygote not_considered Early adult Clinical Chemistry Total cholesterol ICS IMPC 5.63E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_CBC_015_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_CBC_003¶meter_stable_id=IMPC_CBC_015_001&phenotyping_center=ICS abnormal retina outer nuclear layer morphology Aak1 homozygote not_considered Early adult Eye Morphology Left outer nuclear layer ICS IMPC 6.76E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_EYE_070_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_EYE_003¶meter_stable_id=IMPC_EYE_070_001&phenotyping_center=ICS abnormal contextual conditioning behavior Aak1 homozygote not_considered Early adult Fear Conditioning % Freezing duration context-1 ICS IMPC 6.89E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=ICS_FEA_006_001&pipeline_stable_id=ICS_001&procedure_stable_id=ICS_FEA_001¶meter_stable_id=ICS_FEA_006_001&phenotyping_center=ICS hyperactivity Aak1 homozygote not_considered Early adult Open Field Whole arena average speed ICS IMPC 6.98E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_OFD_009_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_OFD_001¶meter_stable_id=IMPC_OFD_009_001&phenotyping_center=ICS impaired glucose tolerance Aak1 homozygote male Early adult Intraperitoneal glucose tolerance test (IPGTT) Initial response to glucose challenge ICS IMPC 8.41E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=IMPC_IPG_011_001&pipeline_stable_id=ICS_001&procedure_stable_id=IMPC_IPG_001¶meter_stable_id=IMPC_IPG_011_001&phenotyping_center=ICS abnormal contextual conditioning behavior Aak1 homozygote not_considered Early adult Fear Conditioning % Freezing duration context-2 ICS IMPC 9.62E-5 //dev.mousephenotype.org/data/charts?accession=MGI:1098687&allele_accession_id=MGI:5766745&zygosity=homozygote¶meter_stable_id=ICS_FEA_007_001&pipeline_stable_id=ICS_001&procedure_stable_id=ICS_FEA_001¶meter_stable_id=ICS_FEA_007_001&phenotyping_center=ICS