The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|preweaning lethality, complete penetrance||Alg6em1(IMPC)Tcp||HOM||Early adult||0.00|
|abnormal embryo size||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|embryonic growth retardation||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|abnormal sensory capabilities/reflexes/nociception||Alg6em1(IMPC)Tcp||HET||Early adult||0.000158 *|
|abnormal embryo development||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|enlarged lymph nodes||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
|abnormal allantois morphology||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|abnormal skin morphology||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
|prenatal lethality prior to heart atrial septation||Alg6em1(IMPC)Tcp||HOM||E15.5||0.00|
|enlarged urinary bladder||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Alg6 by orthology or direct annotation.
The table below shows human diseases predicted to be associated to Alg6 by phenotypic similarity.
|Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation||
||Generalized lymphadenopathy, Absent tonsils, Hepatomegaly, Aplasia of the thymus, Lymph node hypo...||OMIM:602450|
|T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency||
||Lymph node hypoplasia, Hepatomegaly, Absent tonsils||ORPHA:276|
||Lymph node hypoplasia, Absence of lymph node germinal center||ORPHA:90186|
|Purine Nucleoside Phosphorylase Deficiency||
||Lymph node hypoplasia, Splenomegaly||OMIM:613179|
||Lymph node hypoplasia||OMIM:300755|
|Congenital Disorder Of Glycosylation, Type Ic||
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|MGI Allele||Allele Type||Produced|
|Alg6tm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Alg6tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|