Gene Summary

Name:
yippee like 2
Synonyms:
E130113K08Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
prolonged QT interval Ypel2em1(IMPC)Tcp HOM Early adult 2.12×10-06
decreased prepulse inhibition Ypel2em1(IMPC)Tcp HOM   Early adult 1.78×10-05
abnormal sternum morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
enlarged urinary bladder Ypel2em1(IMPC)Tcp HOM Early adult 0.00
abnormal eye morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
abnormal tooth morphology Ypel2em1(IMPC)Tcp HOM Early adult 4.21×10-06
decreased body length Ypel2em1(IMPC)Tcp HOM Early adult 8.90×10-05

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Eye Morphology

Images Slit Lamp

21 Images

Eye Morphology

Images Ophthalmoscopy

47 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Gross Pathology and Tissue Collection

Images

9 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Ypel2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ypel2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Jervell And Lange-Nielsen Syndrome 1
Torsade de pointes, Sudden cardiac death, Prolonged QTc interval, Syncope, Prolonged QT interval OMIM:220400
Long Qt Syndrome 2
Torsade de pointes, Sudden cardiac death, Prolonged QTc interval, Syncope, Prolonged QT interval,... OMIM:613688
Long Qt Syndrome 10
Sudden cardiac death, T-wave alternans, Atrial fibrillation, Prolonged QT interval, Atrioventricu... OMIM:611819
Long Qt Syndrome 13
Torsade de pointes, Permanent atrial fibrillation, Palpitations, Pulmonary embolism, Syncope, Pro... OMIM:613485
Long Qt Syndrome 6
Torsade de pointes, Sudden cardiac death, Prolonged QTc interval, Syncope, Prolonged QT interval,... OMIM:613693
Atrial Fibrillation, Familial, 9
Permanent atrial fibrillation, Palpitations, Prolonged QTc interval, Syncope, Paroxysmal atrial f... OMIM:613980
Long Qt Syndrome 1
Torsade de pointes, Sudden cardiac death, Prolonged QTc interval, Syncope, Ventricular fibrillati... OMIM:192500
Long Qt Syndrome 14
Prolonged QTc interval, Prolonged QT interval, T-wave alternans, Ventricular fibrillation, Cardia... OMIM:616247
Atrial Fibrillation, Familial, 3
Permanent atrial fibrillation, Sudden cardiac death, Prolonged QTc interval, Syncope, Atrial fibr... OMIM:607554
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3
Cardiac arrest, Premature ventricular contraction, Polymorphic ventricular tachycardia, Bidirecti... OMIM:614021
Long Qt Syndrome 11
Syncope, Prolonged QTc interval OMIM:611820
Brugada Syndrome 9
Presyncope, Palpitations, ST segment elevation, Prolonged QT interval OMIM:616399
Long Qt Syndrome 9
Cardiac arrest, Abnormal U wave, Ventricular arrhythmia, Syncope, Sinus bradycardia, Prolonged QT... OMIM:611818
Regional Odontodysplasia
Macrodontia, Delayed eruption of teeth, Carious teeth, Yellow-brown discoloration of the teeth, D... ORPHA:83450
Andersen-Tawil Syndrome
High palate, Abnormality of the dentition, Bidirectional ventricular ectopy, Hypoplasia of the ma... ORPHA:37553
Andersen Cardiodysrhythmic Periodic Paralysis
High palate, Cleft palate, Bidirectional ventricular ectopy, Small finger, Hypoplasia of the maxi... OMIM:170390
Cardiac Arrhythmia Syndrome, With Or Without Skeletal Muscle Weakness
Cardiac arrest, Premature ventricular contraction, Polymorphic ventricular tachycardia, Syncope, ... OMIM:615441
Jervell And Lange-Nielsen Syndrome 2
Torsade de pointes, Premature ventricular contraction, Sudden cardiac death, Syncope, Prolonged Q... OMIM:612347
Progressive Familial Heart Block, Type Ib
Left anterior fascicular block, Arrhythmia, Syncope, Shortened PR interval, Right bundle branch b... OMIM:604559
Sick Sinus Syndrome 1
Ventricular escape rhythm, Sick sinus syndrome, Absent P wave, Sinus bradycardia, Prolonged QT in... OMIM:608567
Long Qt Syndrome 8
Sudden cardiac death, Syndactyly, Prolonged QTc interval, Syncope, Ventricular fibrillation, Sinu... OMIM:618447
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Left anterior fascicular block, Atrial arrhythmia, Premature ventricular contraction, Tachycardia... OMIM:616117
Cardiac Arrhythmia, Ankyrin-B-Related
Sudden cardiac death, Syncope, Atrial fibrillation, Sinus bradycardia, Prolonged QT interval OMIM:600919
Long Qt Syndrome 16
T-wave alternans, Second degree atrioventricular block, Bradycardia, Prolonged QTc interval OMIM:618782
Myofibrillar Myopathy 10
Left ventricular hypertrophy, Prolonged QTc interval, Sandal gap, Increased QRS voltage, Mandibul... OMIM:619040
Long Qt Syndrome 5
Torsade de pointes, Sudden cardiac death, Prolonged QTc interval, Syncope, Ventricular fibrillati... OMIM:613695
Amelogenesis Imperfecta
Taurodontia, Fragile teeth, Abnormal jaw morphology, Anterior open-bite malocclusion, Multiple un... ORPHA:88661
Long Qt Syndrome 12
Torsade de pointes, Ventricular fibrillation, Syncope, Prolonged QTc interval OMIM:612955
Sick Sinus Syndrome 2
Torsade de pointes, Left ventricular hypertrophy, Sudden cardiac death, Syncope, Atrial fibrillat... OMIM:163800
Cardiomyopathy, Dilated, 1D
Left ventricular hypertrophy, Sudden cardiac death, Increased left ventricular end-diastolic volu... OMIM:601494
Timothy Syndrome
Cutaneous syndactyly, Syndactyly, Microdontia, Thin upper lip vermilion, Prolonged QT interval, C... OMIM:601005
Atrial Fibrillation, Familial, 7
Permanent atrial fibrillation, Premature atrial contractions, Palpitations, Prolonged QTc interva... OMIM:612240
Cardiomyopathy, Familial Hypertrophic 27
Cardiac arrest, Tricuspid regurgitation, Concentric hypertrophic cardiomyopathy, Right ventricula... OMIM:618052
Long Qt Syndrome 15
Polymorphic ventricular tachycardia, Ventricular bigeminy, Ventricular ectopy, Prolonged QTc inte... OMIM:616249
Long Qt Syndrome 3
Torsade de pointes, Ventricular flutter, Sudden cardiac death, Prolonged QTc interval, Syncope, V... OMIM:603830
Tako-Tsubo Cardiomyopathy
Angina pectoris, ST segment depression, Mitral regurgitation, Palpitations, Decreased QRS voltage... ORPHA:66529
Sick Sinus Syndrome 4
Abnormal QT interval, Abnormal QRS complex, Sinoatrial block, Syncope, Chronotropic incompetence,... OMIM:619464
3-Methylglutaconic Aciduria, Type V
3-Methylglutaric aciduria, Hypospadias, Sudden cardiac death, Dilated cardiomyopathy, Noncompacti... OMIM:610198
Romano-Ward Syndrome
Torsade de pointes, Abnormal T-wave, Sudden cardiac death, Ventricular arrhythmia, Syncope, Prolo... ORPHA:101016
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Amelogenesis imperfecta, Anterior open-bite malocclusion, Abnormal dental enamel morphology, Cari... OMIM:204700
Cardiomyopathy, Familial Hypertrophic, 26
Left anterior fascicular block, Permanent atrial fibrillation, Left bundle branch block, Mitral r... OMIM:617047
Amelogenesis Imperfecta, Type Ij
Carious teeth, Enamel hypoplasia, Widely spaced teeth, Increased overbite, Amelogenesis imperfecta OMIM:617297
Metaphyseal Chondrodysplasia, Spahr Type
Metaphyseal dysplasia, Abnormality of the dentition, Genu varum, Short lower limbs, Carious teeth... ORPHA:2501
Familial Short Qt Syndrome
Sudden cardiac death, Palpitations, Ventricular arrhythmia, Syncope, Ventricular fibrillation, At... ORPHA:51083
Jervell And Lange-Nielsen Syndrome
Torsade de pointes, Arrhythmia, Prolonged QTc interval, Syncope, Ventricular fibrillation ORPHA:90647
Dentin Dysplasia, Type I
Taurodontia, Dentinogenesis imperfecta limited to primary teeth, Microdontia, Pulp obliteration, ... OMIM:125400
Brugada Syndrome 3
J wave, Sudden cardiac death, Ventricular arrhythmia, Syncope, Atrial fibrillation, Shortened QT ... OMIM:611875
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Amelogenesis imperfecta, Carious teeth OMIM:615887
Oligodontia
Eclabion, Abnormality of canine, Delayed eruption of teeth, Microdontia, Hypoplasia of teeth, Peg... ORPHA:99798
Dental Ankylosis
Mandibular prognathia, Tooth agenesis, Clinodactyly of the 5th finger, Abnormal dental enamel mor... ORPHA:1077
Short Qt Syndrome 1
Cardiac arrest, Palpitations, Sudden cardiac death, Syncope, Paroxysmal atrial fibrillation, Shor... OMIM:609620
Dentinogenesis Imperfecta
Persistence of primary teeth, Fragile teeth, Generalized hypoplasia of dental enamel, Finger join... ORPHA:49042
Sinoatrial Node Dysfunction And Deafness
Bradycardia, Increased heart rate variability, Abnormal QRS complex, Syncope OMIM:614896
Cirrhotic Cardiomyopathy
Fourth heart sound, Hepatomegaly, Left ventricular hypertrophy, Left ventricular diastolic dysfun... ORPHA:57777
Neonatal Lupus Erythematosus
Hepatomegaly, Splenomegaly, Arrhythmia, Abnormal electrophysiology of sinoatrial node origin, Dil... ORPHA:398124
Taurodontism, Microdontia, And Dens Invaginatus
Dens in dente, Taurodontia, Microdontia, Pulp calcification OMIM:313490
Short Qt Syndrome 2
Sudden cardiac death, Syncope, Ventricular fibrillation, Atrial fibrillation, Shortened QT interv... OMIM:609621
Incessant Infant Ventricular Tachycardia
Bundle branch block, Wolff-Parkinson-White syndrome, Supraventricular tachycardia, Prolonged QRS ... ORPHA:45453
Pseudohypoparathyroidism Type 1B
Diaphyseal sclerosis, Delayed eruption of teeth, Enamel hypoplasia, Cortical subperiosteal resorp... ORPHA:94089
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Anterior open-bite malocclusion, Amelogenesis imperfecta, Abnormal dental enamel morphology OMIM:612529
Brugada Syndrome
Supraventricular tachycardia, Trifascicular block, Paroxysmal ventricular tachycardia, Tachycardi... ORPHA:130
Florid Cemento-Osseous Dysplasia
Dental malocclusion, Abnormal number of teeth, Mandibular osteomyelitis, Abnormal cementum morpho... ORPHA:83451
Familial Hyperaldosteronism Type Iii
Left ventricular hypertrophy, Intracranial hemorrhage, Epistaxis, Hypercalciuria, Hypertension, P... ORPHA:251274
Dentinogenesis Imperfecta, Shields Type Iii
Dentinogenesis imperfecta, Anterior open-bite malocclusion, Dental enamel pits, Odontodysplasia, ... OMIM:125500
Otodental Dysplasia
Taurodontia, Agenesis of premolar, Long philtrum, Delayed eruption of teeth, Pulp calcification, ... OMIM:166750
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Prolonged QT interval, Arrhythmia ORPHA:2151
Idiopathic Neonatal Atrial Flutter
Supraventricular tachycardia, Abnormal left ventricular function, Arrhythmia, Abnormal QRS comple... ORPHA:45452
Pyle Disease
Metaphyseal dysplasia, Metaphyseal widening, Delayed eruption of teeth, Carious teeth, Hypoplasti... OMIM:265900
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 14
Prolonged QT interval OMIM:615351
Rubinstein-Taybi Syndrome 2
High palate, Dental malocclusion, Narrow palate, Retrognathia, Micrognathia, Syndactyly, Carious ... OMIM:613684
Acquired Aneurysmal Subarachnoid Hemorrhage
Cerebral hemorrhage, ST segment depression, Left ventricular hypertrophy, Cerebral ischemia, Sync... ORPHA:90065
Amelogenesis Imperfecta, Type Iiia
Dental malocclusion, Amelogenesis imperfecta, Anterior open-bite malocclusion OMIM:130900
Amelogenesis Imperfecta, Type Ic
Taurodontia, Anterior open-bite malocclusion, Enamel hypomineralization, Yellow-brown discolorati... OMIM:204650
Pseudohypoparathyroidism Type 2
Prolonged QT interval ORPHA:94090
Wolff-Parkinson-White Syndrome
Wolff-Parkinson-White syndrome, Prolonged QRS complex, Ventricular preexcitation with multiple ac... OMIM:194200
Amelogenesis Imperfecta, Type Ih
Anterior open-bite malocclusion, Enamel hypoplasia, Yellow-brown discoloration of the teeth, Dent... OMIM:616221
Autoimmune Hypoparathyroidism
Abnormal left ventricular function, Prolonged QT interval, Ventricular arrhythmia, Calcium nephro... ORPHA:36913
Rett Syndrome
Abnormality of the dentition, Abnormal T-wave, Short foot, Prolonged QTc interval OMIM:312750
Short Qt Syndrome 3
Palpitations, Tachycardia, Shortened QT interval OMIM:609622
Atrial Standstill
Ventricular escape rhythm, Abnormal P wave, Atrial standstill, Palpitations, Mobitz I atrioventri... ORPHA:1344
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Tachycardia, Arrhythmia, Dilated cardiomyopathy, Ventricular tachycardia, Ventricul... ORPHA:26793
Brugada Syndrome 4
Atrial fibrillation, Shortened QT interval, Syncope OMIM:611876
Simpson-Golabi-Behmel Syndrome
Wide mouth, Hepatomegaly, Cleft palate, Congenital hip dislocation, Mandibular prognathia, Prolon... ORPHA:373
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5
Prolonged QRS complex, Premature ventricular contraction, Right ventricular cardiomyopathy, Presy... OMIM:604400
Muscular Dystrophy, Becker Type
Abnormal EKG, Arrhythmia, Cardiomyopathy OMIM:300376
Muscular Dystrophy, Cardiac Type
Abnormal EKG, Cardiomyopathy, Carnosinuria OMIM:309930
Cardiomyopathy, Familial Hypertrophic, 6
Wolff-Parkinson-White syndrome, Prolonged QRS complex, Left bundle branch block, Atrioventricular... OMIM:600858
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
Prolonged QRS complex, Right ventricular cardiomyopathy, Ventricular arrhythmia, Syncope, T-wave ... OMIM:611528
Otodental Syndrome
Gingival overgrowth, Taurodontia, Periodontitis, Agenesis of premolar, Abnormality of canine, Abn... ORPHA:2791
Nathalie Syndrome
Abnormal EKG OMIM:255990
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Hypocalcification of dental enamel, Yellow-brown discoloration of the te... OMIM:618386
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Epsilon wave, Premature ventricular contraction, Right ventricular cardiomyopathy, Palpitations, ... OMIM:610193
Pseudohypoparathyroidism Type 1C
Short fifth metatarsal, Brachydactyly, Delayed eruption of teeth, Short 3rd metacarpal, Enamel hy... ORPHA:79444
Cocaine Intoxication
Supraventricular arrhythmia, Prolonged QRS complex, Cerebral hemorrhage, Diffuse alveolar hemorrh... ORPHA:90068
Epidermolysis Bullosa, Junctional 1A, Intermediate
Oral mucosal blisters, Hypodontia, Camptodactyly of finger, Carious teeth, Enamel hypoplasia OMIM:226650
Amelogenesis Imperfecta, Type If
Enamel hypoplasia, Amelogenesis imperfecta, Dental enamel pits, Abnormality of dental color OMIM:616270
Atrial Fibrillation, Familial, 11
Atrial fibrillation, Prolonged QRS complex, Prolonged P wave OMIM:614049
Cardiomyopathy, Familial Hypertrophic, 10
Supraventricular tachycardia, Left bundle branch block, Left ventricular hypertrophy, Palpitation... OMIM:608758
Ethylene Glycol Poisoning
Renal tubular dysfunction, Tachycardia, Hematuria, Hypotension, Atrial fibrillation, Shock, Renal... ORPHA:31826
Amelogenesis Imperfecta, Type Iv
Enamel hypoplasia, Yellow-brown discoloration of the teeth, Taurodontia, Amelogenesis imperfecta OMIM:104510
Lipodystrophy, Congenital Generalized, Type 4
Hepatomegaly, Splenomegaly, Tachycardia, Atrial fibrillation, Prolonged QT interval, Bradycardia OMIM:613327
Cardiomyopathy, Familial Hypertrophic, 8
Restrictive cardiomyopathy, Left ventricular hypertrophy, Sudden cardiac death, Palpitations, T-w... OMIM:608751
Drug-Induced Lupus Erythematosus
Pericarditis, Hematuria, Prolonged QTc interval ORPHA:231111
Dilated Cardiomyopathy With Ataxia
Hypoplasia of penis, Dilated cardiomyopathy, 3-Methylglutaconic aciduria, Perineal hypospadias, P... ORPHA:66634
Gitelman Syndrome
Polyuria, Hypocalciuria, Nocturia, Palpitations, Hypotension, Ventricular tachycardia, Renal pota... OMIM:263800
Pseudohypoparathyroidism Type 1A
Short fifth metatarsal, Brachydactyly, Delayed eruption of teeth, Short 3rd metacarpal, Enamel hy... ORPHA:79443
Cerebral Creatine Deficiency Syndrome 1
Mandibular prognathia, Prolonged QT interval, Malar flattening OMIM:300352
17Q24.2 Microdeletion Syndrome
Tooth malposition, Pulmonic stenosis, Micrognathia, Short philtrum, Upper limb undergrowth, Prolo... ORPHA:529962
Hypophosphatemic Rickets, Autosomal Recessive, 2
Medullary nephrocalcinosis, Pulmonic stenosis, Genu varum, Carious teeth, Genu valgum, Hyperphosp... OMIM:613312
Brugada Syndrome 7
Permanent atrial fibrillation, Prolonged P wave, ST segment elevation, Atrial flutter, Paroxysmal... OMIM:613120
Cleidocranial Dysplasia
Cleft palate, Abnormality of the dentition, Down-sloping shoulders, Delayed eruption of teeth, Ta... ORPHA:1452
Gitelman Syndrome
Renal tubular acidosis, Abnormal T-wave, ST segment depression, Raynaud phenomenon, Palpitations,... ORPHA:358
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Torsade de pointes, Ketonuria, Myoglobinuria, Prolonged QTc interval, Ventricular tachycardia, Ve... OMIM:616878
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Ketonuria, Abnormal EKG, Prolonged QT interval, Arrhythmia ORPHA:480864
Amelo-Onycho-Hypohidrotic Syndrome
Abnormal dental enamel morphology, Tooth agenesis, Everted lower lip vermilion, Delayed eruption ... ORPHA:1028
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Myoglobinuria, Dicarboxylic aciduria, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Prolon... ORPHA:71212
Dentin Dysplasia, Type Ii
Abnormal dentin morphology, Dentinogenesis imperfecta limited to primary teeth, Pulp calcification OMIM:125420
Attrv122I Amyloidosis
Angina pectoris, Atrial arrhythmia, Aortic valve stenosis, Restrictive cardiomyopathy, Left ventr... ORPHA:85451
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Prolonged QRS complex, Epsilon wave, Premature ventricular contraction, Right ventricular cardiom... OMIM:609040
Thyrotoxic Periodic Paralysis
Palpitations, Decreased urinary potassium, Shortened PR interval, Urinary retention, Second degre... ORPHA:79102
Craniometadiaphyseal Dysplasia
High palate, Broad long bones, Malar flattening, Flared metaphysis, Microdontia, Genu varum, Cari... OMIM:269300
Cardiomyopathy, Dilated, 1Nn
Mitral regurgitation, Abnormal ST segment, Ventricular arrhythmia, Increased left ventricular end... OMIM:615916
Cardiomyopathy, Familial Hypertrophic, 13
Angina pectoris, Left anterior fascicular block, ST segment depression, Concentric hypertrophic c... OMIM:613243
Pycnodysostosis
Narrow palate, Persistence of primary teeth, Hypodontia, Micrognathia, Narrow iliac wing, Brachyd... OMIM:265800
45,X/46,Xy Mixed Gonadal Dysgenesis
High palate, Urogenital sinus anomaly, Chordee, Micropenis, Micrognathia, Hypospadias, Tachycardi... ORPHA:1772
Turner Syndrome Due To Structural X Chromosome Anomalies
High palate, Short sternum, Abnormality of the dentition, Irregular proximal tibial epiphyses, Hi... ORPHA:99413
Turner Syndrome
High palate, Short sternum, Abnormality of the dentition, Irregular proximal tibial epiphyses, Hi... ORPHA:881
Mosaic Monosomy X
High palate, Short sternum, Abnormality of the dentition, Irregular proximal tibial epiphyses, Hi... ORPHA:99228
Monosomy X
High palate, Short sternum, Abnormality of the dentition, Irregular proximal tibial epiphyses, Hi... ORPHA:99226
Coronary Arterial Fistula
Angina pectoris, Abnormal left ventricular function, Aortic valve stenosis, Systolic heart murmur... ORPHA:2041
Oculodentodigital Dysplasia, Autosomal Recessive
Dental malocclusion, Narrow mouth, Broad long bones, Macrodontia of permanent maxillary central i... OMIM:257850
Wild Type Attr Amyloidosis
Nephrotic syndrome, Hepatomegaly, Orthostatic hypotension due to autonomic dysfunction, Nephropat... ORPHA:330001
Sternum, Premature Obliteration Of Sutures Of
Micrognathia, Short sternum OMIM:184800
Congenital Left Ventricular Aneurysm
Abnormal ST segment, Abnormal T-wave, Arrhythmia, Congestive heart failure ORPHA:1055
Tropical Endomyocardial Fibrosis
Pulmonary venous hypertension, Hepatomegaly, Systolic heart murmur, Decreased QRS voltage, Reduce... ORPHA:75565
Cardiogenic Shock
Abnormal left ventricular function, Low pulse pressure, Increased pulmonary capillary wedge press... ORPHA:97292
Atrial Septal Defect, Ostium Primum Type
Systolic heart murmur, Right bundle branch block, Atrioventricular block, Palpitations, Syncope, ... ORPHA:99106
Orofaciodigital Syndrome Iii
Supernumerary tooth, Short sternum, Bifid tongue, Bifid uvula, Microdontia, Postaxial hand polyda... OMIM:258850
Complete Atrioventricular Septal Defect
Pulmonary venous hypertension, Atrioventricular block, Hepatomegaly, Abnormal P wave, Right ventr... ORPHA:1329
Dysosteosclerosis
High palate, Premature loss of teeth, Abnormal metaphyseal trabeculation, Short sternum, Short ri... OMIM:224300
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Abnormal pulse pressure, ST segment depression, Hypotension, Oliguria, Acute kid... ORPHA:466650
Multiple Synostoses Syndrome 1
Short sternum, Clinodactyly of the 4th toe, Short philtrum, Symphalangism affecting the phalanges... OMIM:186500
Peripartum Cardiomyopathy
Left bundle branch block, Abnormal T-wave, Left ventricular hypertrophy, Right ventricular failur... ORPHA:563
Brugada Syndrome 6
Cardiac arrest, Ventricular fibrillation, ST segment elevation OMIM:613119
Brugada Syndrome 8
ST segment elevation, Ventricular tachycardia, Right bundle branch block OMIM:613123
Symphalangism, Distal, With Microdontia, Dental Pulp Stones, And Narrowed Zygomatic Arch
Short distal phalanx of finger, Absent trapezoid bone, Cone-shaped epiphyses of the middle phalan... OMIM:606895
Atrial Fibrillation, Familial, 14
Prolonged PR interval, Hypertension, Paroxysmal atrial fibrillation, ST segment elevation OMIM:615378
Pulmonic Stenosis, Atrial Septal Defect, And Unique Electrocardiographic Abnormalities
Pulmonic stenosis, Abnormal EKG OMIM:178650
Brugada Syndrome 5
Bundle branch block, ST segment elevation, Ventricular fibrillation OMIM:612838
Dpagt1-Cdg
Hepatomegaly, Arachnodactyly, Intracranial hemorrhage, Camptodactyly, Clinodactyly, Prolonged QT ... ORPHA:86309
Enamel-Renal Syndrome
Abnormal dental enamel morphology, Impaired renal concentrating ability, Gingival overgrowth, Hyp... ORPHA:1031
Familial Osteodysplasia, Anderson Type
Clinodactyly of the 5th finger, Tooth malposition, Malar flattening, Failure of eruption of perma... ORPHA:2769
Amelogenesis Imperfecta, Type Ig
Impaired renal concentrating ability, Gingival overgrowth, Dagger-shaped pulp calcifications, Pol... OMIM:204690
Orofaciodigital Syndrome Type 2
High palate, Cone-shaped epiphyses of the phalanges of the hand, Cleft palate, Complete duplicati... ORPHA:2751
Early-Onset Cerebellar Ataxia With Retained Tendon Reflexes
Abnormal EKG ORPHA:1177
Hyperparathyroidism-Jaw Tumor Syndrome
Nephrolithiasis, Mandibular pain, Hypercalciuria, Shortened QT interval, Renal cyst, Renal insuff... ORPHA:99880
Atrial Septal Defect, Ostium Secundum Type
Supraventricular arrhythmia, Bundle branch block, Supraventricular tachycardia, Abnormal left ven... ORPHA:99103
Parathyroid Carcinoma
Nephrolithiasis, Mandibular pain, Hypercalciuria, Shortened QT interval, Renal cyst, Renal insuff... ORPHA:143
Al Amyloidosis
Nephrotic syndrome, Hepatomegaly, Abnormal P wave, Macroglossia, Jaw claudication, Arrhythmia, Ab... ORPHA:85443
Congenital Aortic Valve Stenosis
Angina pectoris, Abnormal left ventricular function, Abnormal T-wave, Aortic valve stenosis, Abno... ORPHA:3093
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Congenital Sialidosis Type 2
Gingival overgrowth, Hepatomegaly, Hepatosplenomegaly, Polydactyly, Protruding tongue, Abnormal E... ORPHA:93400
Coffin-Lowry Syndrome
High palate, Dental malocclusion, Drumstick terminal phalanges, Narrow palate, Hypodontia, Everte... OMIM:303600
Dextrocardia
Abnormality of the ureter, Congenital hip dislocation, Abnormal rib morphology, T-wave inversion,... ORPHA:1666
Congenitally Uncorrected Transposition Of The Great Arteries
Cardiac shunt, Hepatomegaly, Left ventricular outflow tract obstruction, Right ventricular hypert... ORPHA:860
Cerebellar-Facial-Dental Syndrome
Alveolar ridge overgrowth, Dental malocclusion, Taurodontia, Macrodontia of permanent maxillary c... ORPHA:444072
Muscular Dystrophy, Duchenne Type
Arrhythmia, Dilated cardiomyopathy, Abnormal EKG, Cardiomyopathy, Congestive heart failure OMIM:310200
Yunis-Varon Syndrome
Slender long bones with narrow diaphyses, Absent thumb, Short philtrum, Tapered finger, Short pro... ORPHA:3472
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Right ventricular hypertrophy, Reduced left ventricular ejection fraction, Abnormal EKG, Right bu... ORPHA:268
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Abnormal T-wave, Increased urinary potassium, Palpitations, Intracranial hemorrhage, Hypertension... ORPHA:231625
Multiple Endocrine Neoplasia Type 1
Nephrolithiasis, Melena, Hematemesis, Gingival fibromatosis, Hypercalciuria, Hypertension, Shorte... ORPHA:652
Dopamine Beta-Hydroxylase Deficiency
Elevated urinary dopamine, Orthostatic hypotension, Nocturia, Syncope, Orthostatic syncope, Abnor... ORPHA:230
Friedreich Ataxia
Hypertrophic cardiomyopathy, Abnormal EKG, Congestive heart failure OMIM:229300
Ulbright-Hodes Syndrome
High palate, Aplasia/Hypoplasia of the ulna, Narrow mouth, Short sternum, Long upper lip, Thin ri... ORPHA:3404
Cardiac Diverticulum
Angina pectoris, Mitral stenosis, Aortic valve stenosis, Premature ventricular contraction, Tricu... ORPHA:1686
Craniorachischisis
Bifid sternum ORPHA:63260
Absence Of The Pulmonary Artery
Systolic heart murmur, Tachycardia, Reduced left ventricular ejection fraction, Abnormal EKG, Atr... ORPHA:980
Chronic Thromboembolic Pulmonary Hypertension
Cardiac shunt, Abnormal left ventricular function, Abnormal T-wave, Right ventricular failure, Pa... ORPHA:70591
Friedreich Ataxia And Congenital Glaucoma
Concentric hypertrophic cardiomyopathy, Hammertoe, Abnormal EKG, Hypertrophic cardiomyopathy, Con... OMIM:229310
Friedreich Ataxia 2
Hammertoe, Abnormal EKG, Congestive heart failure, Concentric hypertrophic cardiomyopathy OMIM:601992
African Trypanosomiasis
Hepatomegaly, Splenomegaly, Hepatosplenomegaly, Arrhythmia, Myocarditis, Third degree atrioventri... ORPHA:3385
Charcot-Marie-Tooth Peroneal Muscular Atrophy And Friedreich Ataxia, Combined
Hammertoe, Abnormal EKG, Congestive heart failure, Concentric hypertrophic cardiomyopathy OMIM:302900

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ypel2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ypel2.

No publications found that use IMPC mice or data for Ypel2.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ypel2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ypel2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ypel2em1(IMPC)Tcp Exon Deletion Mice

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