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Gene: Ypel2 MGI:1925114

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Gene Summary

Name:
yippee like 2
Synonyms:
E130113K08Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
abnormal tooth morphology Ypel2em1(IMPC)Tcp HOM Early adult 4.08×10-06
abnormal sternum morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
prolonged QT interval Ypel2em1(IMPC)Tcp HOM Early adult 2.42×10-06
enlarged urinary bladder Ypel2em1(IMPC)Tcp HOM Early adult 0.00
decreased prepulse inhibition Ypel2em1(IMPC)Tcp HOM   Early adult 1.71×10-05
decreased body length Ypel2em1(IMPC)Tcp HOM Early adult 7.48×10-05

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Eye Morphology

Images Ophthalmoscopy

47 Images

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Gross Pathology and Tissue Collection

Images

9 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Eye Morphology

Images Slit Lamp

21 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Electrocardiogram (ECG)

Waveform Image

1 Images

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Human diseases caused by Ypel2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ypel2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Jervell And Lange-Nielsen Syndrome 1
Prolonged QTc interval, Torsade de pointes, Syncope, Sudden cardiac death, Prolonged QT interval OMIM:220400
Long Qt Syndrome 2
Cardiac arrest, Prolonged QTc interval, Torsade de pointes, Syncope, Sudden cardiac death, Ventri... OMIM:613688
Long Qt Syndrome 13
Cardiac arrest, Prolonged QTc interval, Reduced left ventricular ejection fraction, Torsade de po... OMIM:613485
Long Qt Syndrome 10
T-wave alternans, Sudden cardiac death, Atrioventricular block, Prolonged QT interval, Atrial fib... OMIM:611819
Long Qt Syndrome 6
Cardiac arrest, Prolonged QTc interval, Torsade de pointes, Syncope, Sudden cardiac death, Ventri... OMIM:613693
Long Qt Syndrome 14
Cardiac arrest, Prolonged QTc interval, T-wave alternans, Ventricular fibrillation, 2:1 atriovent... OMIM:616247
Long Qt Syndrome 1
Prolonged QTc interval, Torsade de pointes, Syncope, Sudden cardiac death, Ventricular fibrillati... OMIM:192500
Atrial Fibrillation, Familial, 9
Prolonged QTc interval, Paroxysmal atrial fibrillation, Syncope, Palpitations, Permanent atrial f... OMIM:613980
Atrial Fibrillation, Familial, 3
Prolonged QTc interval, Paroxysmal atrial fibrillation, Syncope, Sudden cardiac death, Permanent ... OMIM:607554
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3
Cardiac arrest, Ventricular tachycardia, Syncope, Palpitations, Bidirectional ventricular tachyca... OMIM:614021
Long Qt Syndrome 11
Prolonged QTc interval, Syncope OMIM:611820
Brugada Syndrome 9
ST segment elevation, Palpitations, Prolonged QT interval, Presyncope OMIM:616399
Long Qt Syndrome 9
Cardiac arrest, Syncope, Abnormal U wave, Sinus bradycardia, Prolonged QT interval, Ventricular a... OMIM:611818
Andersen-Tawil Syndrome
Prolonged QTc interval, Oligodontia, Renal tubular dysfunction, Abnormal T-wave, Torsade de point... ORPHA:37553
Regional Odontodysplasia
Abnormal dental pulp morphology, Mandibular pain, Carious teeth, Short dental root, Eruption fail... ORPHA:83450
Andersen Cardiodysrhythmic Periodic Paralysis
Prolonged QTc interval, Oligodontia, Short metatarsal, Small finger, Cleft palate, Toe syndactyly... OMIM:170390
Cardiac Arrhythmia Syndrome, With Or Without Skeletal Muscle Weakness
Cardiac arrest, Syncope, Polymorphic ventricular tachycardia, Premature ventricular contraction, ... OMIM:615441
Jervell And Lange-Nielsen Syndrome 2
Torsade de pointes, Syncope, Sudden cardiac death, Premature ventricular contraction, Prolonged Q... OMIM:612347
Progressive Familial Heart Block, Type Ib
Left anterior fascicular block, Syncope, Arrhythmia, Atrioventricular block, Shortened PR interva... OMIM:604559
Sick Sinus Syndrome 1
Absent P wave, Sick sinus syndrome, Sinus bradycardia, Atrioventricular block, Prolonged QT inter... OMIM:608567
Long Qt Syndrome 8
Prolonged QTc interval, Syncope, Aborted sudden cardiac death, Syndactyly, Sudden cardiac death, ... OMIM:618447
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Cardiac arrest, Prolonged QTc interval, Left anterior fascicular block, Atrial fibrillation, Paro... OMIM:616117
Cardiac Arrhythmia, Ankyrin-B-Related
Syncope, Sudden cardiac death, Sinus bradycardia, Prolonged QT interval, Atrial fibrillation OMIM:600919
Long Qt Syndrome 16
Prolonged QTc interval, Bradycardia, Second degree atrioventricular block, T-wave alternans OMIM:618782
Myofibrillar Myopathy 10
Prolonged QTc interval, Left ventricular hypertrophy, Mandibular prognathia, Flexion contracture ... OMIM:619040
Cardiomyopathy, Dilated, 1D
Reduced left ventricular ejection fraction, Left ventricular hypertrophy, Sudden cardiac death, C... OMIM:601494
Long Qt Syndrome 12
Prolonged QTc interval, Syncope, Torsade de pointes, Ventricular fibrillation OMIM:612955
Long Qt Syndrome 5
Prolonged QTc interval, Torsade de pointes, Syncope, Sudden cardiac death, Sinus bradycardia, Ven... OMIM:613695
Long Qt Syndrome 15
Cardiac arrest, Prolonged QTc interval, Syncope, Ventricular bigeminy, Polymorphic ventricular ta... OMIM:616249
Sick Sinus Syndrome 2
Cardiac arrest, Prolonged QTc interval, Paroxysmal atrial fibrillation, Left ventricular hypertro... OMIM:163800
Cardiomyopathy, Familial Hypertrophic, 27
Cardiac arrest, Left ventricular diastolic dysfunction, Concentric hypertrophic cardiomyopathy, M... OMIM:618052
Amelogenesis Imperfecta
Abnormal jaw morphology, Multiple unerupted teeth, Fragile teeth, Abnormality of permanent molar ... ORPHA:88661
Atrial Fibrillation, Familial, 7
Prolonged QTc interval, Paroxysmal atrial fibrillation, Palpitations, Premature atrial contractio... OMIM:612240
Long Qt Syndrome 3
Prolonged QTc interval, Ventricular tachycardia, Torsade de pointes, Syncope, Sudden cardiac deat... OMIM:603830
Dentin Dysplasia, Type I
Oligodontia, Periapical bone loss, Taurodontia, Enamel hypoplasia, Microdontia, Short dental root... OMIM:125400
Sick Sinus Syndrome 4
Paroxysmal atrial fibrillation, Syncope, Sinoatrial block, Abnormal QT interval, Sinus bradycardi... OMIM:619464
Timothy Syndrome
Pulmonary arterial hypertension, Ventricular tachycardia, Microdontia, Cutaneous syndactyly, Atri... OMIM:601005
Cardiomyopathy, Familial Hypertrophic, 26
Prolonged QTc interval, Left anterior fascicular block, Mitral regurgitation, Sudden cardiac deat... OMIM:617047
Romano-Ward Syndrome
Prolonged QTc interval, Abnormal T-wave, Torsade de pointes, Syncope, Sudden cardiac death, Sinus... ORPHA:101016
Amelogenesis Imperfecta, Type Ij
Widely spaced teeth, Amelogenesis imperfecta, Enamel hypoplasia, Carious teeth, Increased overbite OMIM:617297
Metaphyseal Chondrodysplasia, Spahr Type
Metaphyseal chondrodysplasia, Short lower limbs, Abnormality of the dentition, Abnormal metaphysi... ORPHA:2501
Familial Short Qt Syndrome
Syncope, Palpitations, Shortened QT interval, Sudden cardiac death, Atrioventricular block, Ventr... ORPHA:51083
Jervell And Lange-Nielsen Syndrome
Prolonged QTc interval, Torsade de pointes, Syncope, Arrhythmia, Ventricular fibrillation ORPHA:90647
Brugada Syndrome 3
Syncope, Shortened QT interval, Sudden cardiac death, Ventricular arrhythmia, Atrial fibrillation... OMIM:611875
3-Methylglutaconic Aciduria, Type V
Noncompaction cardiomyopathy, 3-Methylglutaconic aciduria, Sudden cardiac death, Congestive heart... OMIM:610198
Tako-Tsubo Cardiomyopathy
Prolonged QTc interval, ST segment elevation, Mitral regurgitation, Hypotension, Syncope, Palpita... ORPHA:66529
Short Qt Syndrome 1
Cardiac arrest, Paroxysmal atrial fibrillation, Syncope, Palpitations, Shortened QT interval, Sud... OMIM:609620
Oligodontia
Oligodontia, Widely spaced teeth, Short dental root, Agenesis of mandibular premolar, Delayed eru... ORPHA:99798
Dental Ankylosis
Abnormal dental enamel morphology, Mandibular prognathia, Tooth agenesis, Clinodactyly of the 5th... ORPHA:1077
Dentinogenesis Imperfecta
Grayish enamel, Finger joint hypermobility, Abnormal dental pulp morphology, Selective tooth agen... ORPHA:49042
Sinoatrial Node Dysfunction And Deafness
Bradycardia, Syncope, Abnormal QRS complex, Increased heart rate variability OMIM:614896
Incessant Infant Ventricular Tachycardia
Cardiac arrest, Ventricular tachycardia, Prolonged QRS complex, Left ventricular systolic dysfunc... ORPHA:45453
Cirrhotic Cardiomyopathy
Left ventricular diastolic dysfunction, Third heart sound, Global systolic dysfunction, Reduced l... ORPHA:57777
Short Qt Syndrome 7
Cardiac arrest, Syncope, Shortened QT interval, Sudden cardiac death, Ventricular fibrillation OMIM:620231
Short Qt Syndrome 2
Syncope, Shortened QT interval, Sudden cardiac death, Ventricular fibrillation, Bradycardia, Atri... OMIM:609621
Neonatal Lupus Erythematosus
Abnormal electrophysiology of sinoatrial node origin, Heart block, Arrhythmia, Hepatomegaly, Atri... ORPHA:398124
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Amelogenesis imperfecta, Enamel hypomineralization, Anterior open-bite malocclusion, Carious teet... OMIM:204700
Brugada Syndrome
Cardiac arrest, ST segment elevation, Syncope, Supraventricular tachycardia, Trifascicular block,... ORPHA:130
Amelogenesis Imperfecta, Type Ia
Dental enamel pits, Amelogenesis imperfecta, Taurodontia, Enamel hypoplasia, Generalized microdontia OMIM:104530
Florid Cemento-Osseous Dysplasia
Periapical bone loss, Abnormal cementum morphology, Atrophy of alveolar ridges, Abnormality of pr... ORPHA:83451
Dentinogenesis Imperfecta, Shields Type Iii
Periapical bone loss, Dental enamel pits, Odontodysplasia, Anterior open-bite malocclusion, Denti... OMIM:125500
Otodental Dysplasia
Agenesis of premolar, Tooth ankylosis, Taurodontia, Enamel hypoplasia, Long philtrum, Delayed eru... OMIM:166750
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Arrhythmia, Prolonged QT interval ORPHA:2151
Pyle Disease
Absent paranasal sinuses, Hypoplastic frontal sinuses, Metaphyseal widening, Mandibular prognathi... OMIM:265900
Idiopathic Neonatal Atrial Flutter
Abnormal EKG, Reduced left ventricular ejection fraction, Arrhythmia, Supraventricular tachycardi... ORPHA:45452
Atrial Fibrillation, Familial, 11
Prolonged QRS complex, Prolonged P wave, Atrial fibrillation, Reduced left ventricular ejection f... OMIM:614049
Familial Hyperaldosteronism Type Iii
Left ventricular hypertrophy, Hypertension, Intracranial hemorrhage, Hypercalciuria, Epistaxis, P... ORPHA:251274
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 14
Prolonged QT interval OMIM:615351
Acquired Aneurysmal Subarachnoid Hemorrhage
Prolonged QTc interval, Cerebral hemorrhage, Left ventricular hypertrophy, Syncope, Ischemic stro... ORPHA:90065
Dentin Dysplasia, Type Ii
Dentinogenesis imperfecta limited to primary teeth, Thistle tube shaped pulp, Pulp calcification OMIM:125420
Amelogenesis Imperfecta, Type Ic
Taurodontia, Amelogenesis imperfecta, Enamel hypomineralization, Anterior open-bite malocclusion,... OMIM:204650
Amelogenesis Imperfecta, Type Ih
Dental enamel pits, Amelogenesis imperfecta, Enamel hypoplasia, Yellow-brown discoloration of the... OMIM:616221
Amelogenesis Imperfecta, Type Iiia
Dental malocclusion, Amelogenesis imperfecta, Anterior open-bite malocclusion OMIM:130900
Wolff-Parkinson-White Syndrome
Ventricular preexcitation with multiple accessory pathways, Prolonged QRS complex, Wolff-Parkinso... OMIM:194200
Neurodevelopmental Disorder With Hypotonia, Language Delay, And Skeletal Defects With Or Without Seizures
Camptodactyly, Pulmonary arterial hypertension, 3-4 finger cutaneous syndactyly, Cutaneous syndac... OMIM:620029
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis
High palate, Tooth agenesis, Flattened epiphysis, Advanced ossification of carpal bones, Coxa val... OMIM:618363
Autoimmune Hypoparathyroidism
Abnormal left ventricular function, Ventricular arrhythmia, Prolonged QT interval, Calcium nephro... ORPHA:36913
Short Qt Syndrome 3
Palpitations, Tachycardia, Shortened QT interval OMIM:609622
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Ventricular tachycardia, Tachycardia, Arrhythmia, Hepatomegaly, Atrioventricular block, Dilated c... ORPHA:26793
Atrial Standstill
Mobitz I atrioventricular block, Ventricular tachycardia, Reduced left ventricular ejection fract... ORPHA:1344
Brugada Syndrome 4
Syncope, Atrial fibrillation, Shortened QT interval OMIM:611876
Rett Syndrome
Prolonged QTc interval, Abnormal T-wave, Abnormality of the dentition, Short foot OMIM:312750
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5
Ventricular tachycardia, Prolonged QRS complex, Right ventricular cardiomyopathy, Palpitations, S... OMIM:604400
Simpson-Golabi-Behmel Syndrome
Camptodactyly of finger, Hydroureter, Cardiomyopathy, Hepatomegaly, Cleft palate, Toe syndactyly,... ORPHA:373
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Anterior open-bite malocclusion, Amelogenesis imperfecta, Hypomature enamel, Yellow-brown discolo... OMIM:612529
Muscular Dystrophy, Becker Type
Abnormal EKG, Cardiomyopathy, Arrhythmia OMIM:300376
Amelogenesis Imperfecta, Type Iiic
Anterior open-bite malocclusion, Hypocalcification of dental enamel, Amelogenesis imperfecta, Yel... OMIM:618386
Cardiomyopathy, Familial Hypertrophic, 6
Asymmetric septal hypertrophy, Prolonged QRS complex, Wolff-Parkinson-White syndrome, Syncope, Pa... OMIM:600858
Otodental Syndrome
Abnormal dental pulp morphology, Agenesis of premolar, Taurodontia, Abnormal dental enamel morpho... ORPHA:2791
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
Ventricular tachycardia, Prolonged QRS complex, Right ventricular cardiomyopathy, Syncope, T-wave... OMIM:611528
Nathalie Syndrome
Abnormal EKG OMIM:255990
Muscular Dystrophy, Cardiac Type
Abnormal EKG, Cardiomyopathy, Carnosinuria OMIM:309930
Pseudohypoparathyroidism Type 1B
Diaphyseal sclerosis, Cortical subperiosteal resorption of humeral metaphyses, Enamel hypoplasia,... ORPHA:94089
Cardiomyopathy, Familial Hypertrophic, 8
Cardiac arrest, Reduced left ventricular ejection fraction, Left ventricular hypertrophy, Palpita... OMIM:608751
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Amelogenesis imperfecta, Carious teeth, Yellow-brown discoloration of the teeth OMIM:615887
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Ventricular tachycardia, Epsilon wave, Right ventricular cardiomyopathy, Palpitations, Sudden car... OMIM:610193
Amelogenesis Imperfecta, Type If
Abnormality of dental color, Dental enamel pits, Amelogenesis imperfecta, Enamel hypoplasia OMIM:616270
Pseudohypoparathyroidism Type 1C
Short fifth metatarsal, Broad distal phalanx of the thumb, Short metatarsal, Short 4th metacarpal... ORPHA:79444
Epidermolysis Bullosa, Junctional 1A, Intermediate
Camptodactyly of finger, Enamel hypoplasia, Oral mucosal blisters, Hypodontia, Carious teeth OMIM:226650
Cocaine Intoxication
Subarachnoid hemorrhage, Prolonged QRS complex, Proteinuria, Glomerulonephritis, Diffuse alveolar... ORPHA:90068
Cardiomyopathy, Familial Hypertrophic, 10
Asymmetric septal hypertrophy, Ventricular tachycardia, Left ventricular hypertrophy, Palpitation... OMIM:608758
Amelogenesis Imperfecta, Type Iv
Taurodontia, Amelogenesis imperfecta, Enamel hypoplasia, Yellow-brown discoloration of the teeth OMIM:104510
Amelogenesis Imperfecta, Type Ie
Amelogenesis imperfecta, Enamel hypoplasia, Abnormal dentin morphology, Anterior open-bite malocc... OMIM:301200
Lipodystrophy, Congenital Generalized, Type 4
Tachycardia, Hepatomegaly, Splenomegaly, Bradycardia, Prolonged QT interval, Atrial fibrillation OMIM:613327
Ethylene Glycol Poisoning
Decreased urine output, Hypotension, Tachycardia, Renal insufficiency, Hypertension, Renal tubula... ORPHA:31826
Cerebral Creatine Deficiency Syndrome 1
Malar flattening, Mandibular prognathia, Prolonged QT interval OMIM:300352
Drug-Induced Lupus Erythematosus
Prolonged QTc interval, Pericarditis, Hematuria ORPHA:231111
Pseudohypoparathyroidism Type 1A
Short fifth metatarsal, Broad distal phalanx of the thumb, Short metatarsal, Hypertension, Short ... ORPHA:79443
Dilated Cardiomyopathy With Ataxia
Perineal hypospadias, Hypoplasia of penis, Dilated cardiomyopathy, 3-Methylglutaconic aciduria, P... ORPHA:66634
Gitelman Syndrome
Enuresis, Ventricular tachycardia, Hypotension, Renal magnesium wasting, Palpitations, Polyuria, ... OMIM:263800
Pseudohypoparathyroidism Type 2
Low urinary cyclic AMP response to PTH administration, Prolonged QT interval ORPHA:94090
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Abnormal EKG, Prolonged QT interval, Arrhythmia, Ketonuria ORPHA:480864
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Cardiac arrest, Prolonged QTc interval, Ventricular tachycardia, Torsade de pointes, Myoglobinuri... OMIM:616878
Hypophosphatemic Rickets, Autosomal Recessive, 2
Pulmonic stenosis, Genu varum, Hypoplasia of teeth, Coxa valga, Medullary nephrocalcinosis, Cario... OMIM:613312
Brugada Syndrome 7
ST segment elevation, Paroxysmal atrial fibrillation, Atrial flutter, Prolonged P wave, Permanent... OMIM:613120
Cleidocranial Dysplasia
Cleft palate, Supernumerary tooth, Carious teeth, Brachydactyly, Coxa vara, Down-sloping shoulder... ORPHA:1452
Amelo-Onycho-Hypohidrotic Syndrome
Tooth agenesis, Abnormal dental enamel morphology, Abnormality of dental morphology, Everted lowe... ORPHA:1028
17Q24.2 Microdeletion Syndrome
Tooth malposition, Pulmonic stenosis, Broad thumb, Thin upper lip vermilion, Upper limb undergrow... ORPHA:529962
Cardiomyopathy, Dilated, 1Nn
Mitral regurgitation, Reduced left ventricular ejection fraction, Abnormal ST segment, Congestive... OMIM:615916
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Myoglobinuria, Dicarboxylic aciduria, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Prolon... ORPHA:71212
Gitelman Syndrome
Raynaud phenomenon, Enuresis, Abnormal T-wave, Proteinuria, Tubulointerstitial nephritis, Decreas... ORPHA:358
Attrv122I Amyloidosis
Abnormal EKG, Reduced left ventricular ejection fraction, Left ventricular hypertrophy, Arrhythmi... ORPHA:85451
Thyrotoxic Periodic Paralysis
Urinary retention, Decreased urinary potassium, Palpitations, Impaired myocardial contractility, ... ORPHA:79102
Cardiomyopathy, Familial Hypertrophic, 13
Left anterior fascicular block, Concentric hypertrophic cardiomyopathy, Reduced left ventricular ... OMIM:613243
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Cardiac arrest, Ventricular tachycardia, Prolonged QRS complex, Epsilon wave, Right ventricular c... OMIM:609040
45,X/46,Xy Mixed Gonadal Dysgenesis
High palate, Hallux valgus, Micropenis, Tachycardia, Penoscrotal hypospadias, Horseshoe kidney, E... ORPHA:1772
Pycnodysostosis
Osteolytic defects of the distal phalanges of the hand, Persistence of primary teeth, Delayed eru... OMIM:265800
Craniometadiaphyseal Dysplasia
Absent paranasal sinuses, High palate, Genu varum, Malar flattening, Broad ribs, Coxa valga, Mand... OMIM:269300
Turner Syndrome Due To Structural X Chromosome Anomalies
Hip dysplasia, Horseshoe kidney, Short toe, Short 5th metacarpal, Myocardial infarction, Short st... ORPHA:99413
Turner Syndrome
Hip dysplasia, Horseshoe kidney, Short toe, Short 5th metacarpal, Myocardial infarction, Short st... ORPHA:881
Mosaic Monosomy X
Hip dysplasia, Horseshoe kidney, Short toe, Short 5th metacarpal, Myocardial infarction, Short st... ORPHA:99228
Monosomy X
Hip dysplasia, Horseshoe kidney, Short toe, Short 5th metacarpal, Myocardial infarction, Short st... ORPHA:99226
Coronary Arterial Fistula
Abnormal EKG, Pulmonary arterial hypertension, Systolic heart murmur, Continuous heart murmur, Sy... ORPHA:2041
Glycogen Storage Disease Xv
ST segment elevation, Ventricular fibrillation, Paroxysmal ventricular tachycardia, T-wave invers... OMIM:613507
Congenital Left Ventricular Aneurysm
Arrhythmia, Abnormal T-wave, Congestive heart failure, Abnormal ST segment ORPHA:1055
Wild Type Attr Amyloidosis
Abnormal EKG, Proteinuria, Arrhythmia, Renal insufficiency, Hepatomegaly, Nephropathy, Nephrotic ... ORPHA:330001
Orofaciodigital Syndrome Iii
Postaxial foot polydactyly, Bifid uvula, Microdontia, Tongue nodules, Postaxial hand polydactyly,... OMIM:258850
Tropical Endomyocardial Fibrosis
Prolonged QRS complex, Reduced left ventricular ejection fraction, Pulmonary venous hypertension,... ORPHA:75565
Cardiogenic Shock
Cardiac arrest, Abnormal EKG, ST segment elevation, Mitral regurgitation, Hypotension, Elevated j... ORPHA:97292
Atrial Septal Defect, Ostium Primum Type
Tricuspid regurgitation, Atrial fibrillation, Pulmonary arterial hypertension, Third heart sound,... ORPHA:99106
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Acute kidney injury, Hypotension, Sinus tachycardia, Abnormal pulse pressure, ST... ORPHA:466650
Complete Atrioventricular Septal Defect
Abnormal EKG, Third heart sound, Systolic heart murmur, Elevated jugular venous pressure, Pulmona... ORPHA:1329
Dysosteosclerosis
Absent paranasal sinuses, Oligodontia, Abnormal metaphyseal trabeculation, Premature loss of teet... OMIM:224300
Peripartum Cardiomyopathy
Myocarditis, Pulmonary arterial hypertension, Abnormal T-wave, Mitral regurgitation, Ventricular ... ORPHA:563
Multiple Synostoses Syndrome 1
Lower limb undergrowth, Absent distal phalanges, Carpal synostosis, Short hallux, Asymmetry of th... OMIM:186500
Cardiomyopathy, Familial Restrictive, 3
Hypotension, Reduced left ventricular ejection fraction, Abnormal ST segment, Restrictive cardiom... OMIM:612422
Brugada Syndrome 6
Cardiac arrest, ST segment elevation, Ventricular fibrillation OMIM:613119
Brugada Syndrome 8
ST segment elevation, Ventricular tachycardia, Right bundle branch block OMIM:613123
Pulmonic Stenosis, Atrial Septal Defect, And Unique Electrocardiographic Abnormalities
Abnormal EKG, Pulmonic stenosis OMIM:178650
Dpagt1-Cdg
Camptodactyly, Intracranial hemorrhage, Hepatomegaly, Clinodactyly, Arachnodactyly, Prolonged QT ... ORPHA:86309
Brugada Syndrome 5
ST segment elevation, Bundle branch block, Ventricular fibrillation OMIM:612838
Atrial Fibrillation, Familial, 14
ST segment elevation, Hypertension, Paroxysmal atrial fibrillation, Prolonged PR interval OMIM:615378
Enamel-Renal Syndrome
Enuresis, Nephrocalcinosis, Renal insufficiency, Amelogenesis imperfecta, Abnormal dental enamel ... ORPHA:1031
Familial Osteodysplasia, Anderson Type
Tooth malposition, Malar flattening, Missing ribs, Hypertension, Bifid femur, Mandibular prognath... ORPHA:2769
Amelogenesis Imperfecta, Type Ig
Enuresis, Dagger-shaped pulp calcifications, Nephrocalcinosis, Renal insufficiency, Amelogenesis ... OMIM:204690
Early-Onset Cerebellar Ataxia With Retained Tendon Reflexes
Abnormal EKG, Cardiomyopathy ORPHA:1177
Orofaciodigital Syndrome Type 2
Y-shaped metacarpals, Polysyndactyly of hallux, Short tibia, Preaxial foot polydactyly, Cleft pal... ORPHA:2751
Hyperparathyroidism-Jaw Tumor Syndrome
Renal hamartoma, Nephrocalcinosis, Renal cyst, Mandibular pain, Renal insufficiency, Shortened QT... ORPHA:99880
Cerebrocostomandibular Syndrome
Horseshoe kidney, Cleft palate, Carious teeth, 11 pairs of ribs, Malar flattening, 10 pairs of ri... OMIM:117650
Al Amyloidosis
Macroglossia, Abnormal EKG, Proteinuria, Reduced left ventricular ejection fraction, Abnormal sal... ORPHA:85443
Parathyroid Carcinoma
Renal hamartoma, Nephrocalcinosis, Renal cyst, Mandibular pain, Renal insufficiency, Shortened QT... ORPHA:143
Congenital Aortic Valve Stenosis
Abnormal T-wave, Reduced left ventricular ejection fraction, Left ventricular hypertrophy, Abnorm... ORPHA:3093
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Congenital Sialidosis Type 2
Hepatosplenomegaly, Abnormal EKG, Polydactyly, Hepatomegaly, Protruding tongue, Telangiectasia, G... ORPHA:93400
Coffin-Lowry Syndrome
Open mouth, Bifid sternum, Mitral regurgitation, High palate, Widely spaced teeth, Coxa valga, Sh... OMIM:303600
Dextrocardia
Abnormal EKG, Congenital hip dislocation, Abnormality of the ureter, Abnormal rib morphology, T-w... ORPHA:1666
Congenitally Uncorrected Transposition Of The Great Arteries
Abnormality of blood circulation, Left ventricular outflow tract obstruction, Hepatomegaly, Right... ORPHA:860
Cerebellar-Facial-Dental Syndrome
Hydronephrosis, Abnormal T-wave, Ureteropelvic junction obstruction, Taurodontia, Slender long bo... ORPHA:444072
Muscular Dystrophy, Duchenne Type
Abnormal EKG, Arrhythmia, Cardiomyopathy, Congestive heart failure, Dilated cardiomyopathy OMIM:310200
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Abnormal T-wave, Increased urinary potassium, Palpitations, Hypertension, Intracranial hemorrhage... ORPHA:231625
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Abnormal EKG, Reduced left ventricular ejection fraction, Right ventricular hypertrophy, Cardiome... ORPHA:268
Multiple Endocrine Neoplasia Type 1
Hypertension, Gingival fibromatosis, Shortened QT interval, Hypercalciuria, Nephrolithiasis, Mele... ORPHA:652
Dopamine Beta-Hydroxylase Deficiency
Abnormal EKG, Syncope, Orthostatic syncope, Elevated urinary dopamine, Orthostatic hypotension, N... ORPHA:230
Ulbright-Hodes Syndrome
Short humerus, High palate, Polycystic kidney dysplasia, Abnormal forearm bone morphology, Phocom... ORPHA:3404
Friedreich Ataxia
Abnormal EKG, Congestive heart failure, Hypertrophic cardiomyopathy OMIM:229300
Cardiac Diverticulum
Abnormal EKG, Ventricular tachycardia, Left ventricular hypertrophy, Syncope, Palpitations, Arrhy... ORPHA:1686
Craniorachischisis
Bifid sternum ORPHA:63260
Absence Of The Pulmonary Artery
Abnormal EKG, Pulmonary arterial hypertension, Systolic heart murmur, Reduced left ventricular ej... ORPHA:980
Chronic Thromboembolic Pulmonary Hypertension
Pulmonary arterial hypertension, Abnormal T-wave, Syncope, Palpitations, Pulmonary embolism, Abno... ORPHA:70591
African Trypanosomiasis
Myocarditis, Abnormal EKG, Hepatosplenomegaly, Arrhythmia, Urinary incontinence, Second degree at... ORPHA:3385
Friedreich Ataxia 2
Abnormal EKG, Concentric hypertrophic cardiomyopathy, Congestive heart failure, Hammertoe OMIM:601992

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ypel2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ypel2.

No publications found that use IMPC mice or data for Ypel2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ypel2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ypel2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ypel2em1(IMPC)Tcp Exon Deletion Mice

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