The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| abnormal heart morphology | 1700003F12Riktm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
| abnormal embryo size | 1700003F12Riktm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
| preweaning lethality, incomplete penetrance | 1700003F12Riktm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 | ||
| preweaning lethality, complete penetrance | 1700003F12Riktm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Brain | Section images | heterozygote | 100% (2 of 2) |
| Ovary | Section images | heterozygote | 50% (1 of 2) |
| Spleen | Section images | heterozygote | 100% (2 of 2) |
| Testis | Section images | heterozygote | 50% (1 of 2) |
| Thyroid gland | Section images | heterozygote | 100% (2 of 2) |
| Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
| Aorta | N/A | heterozygote | 0.0% (0 of 2) |
| Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
| Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
| Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
| Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
| Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
| Eye | N/A | heterozygote | 0.0% (0 of 2) |
| Heart | N/A | heterozygote | 0.0% (0 of 2) |
| Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
| Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
| Kidney | N/A | heterozygote | 100% (2 of 2) |
| Large intestine | N/A | heterozygote | 100% (2 of 2) |
| Liver | N/A | heterozygote | 0.0% (0 of 2) |
| Lower urinary tract | N/A | heterozygote | 0.0% (0 of 2) |
| Lung | N/A | heterozygote | 0.0% (0 of 2) |
| Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
| Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
| Oviduct | N/A | heterozygote | 0.0% (0 of 2) |
| Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
| Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
| Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
| Pituitary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Prostate gland | N/A | heterozygote | 0.0% (0 of 2) |
| Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 0.0% (0 of 2) |
| Small intestine | N/A | heterozygote | 50% (1 of 2) |
| Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
| Stomach | N/A | heterozygote | 50% (1 of 2) |
| Striatum | N/A | heterozygote | 0.0% (0 of 2) |
| Thymus | N/A | heterozygote | 0.0% (0 of 2) |
| Trachea | N/A | heterozygote | 0.0% (0 of 2) |
| Uterus | N/A | heterozygote | 0.0% (0 of 2) |
| Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
| White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Axial skeleton | N/A | heterozygote | 0.0% (0 of 2) |
| Brain | N/A | heterozygote | 66.67% (2 of 3) |
| Central nervous system ganglion | N/A | heterozygote | 0.0% (0 of 2) |
| Ear | N/A | heterozygote | 0.0% (0 of 3) |
| Embryo | N/A | heterozygote | 100% (3 of 3) |
| Eye | N/A | heterozygote | 66.67% (2 of 3) |
| Footplate | N/A | heterozygote | 0.0% (0 of 3) |
| Forebrain | N/A | heterozygote | 66.67% (2 of 3) |
| Forelimb | N/A | heterozygote | 0.0% (0 of 3) |
| Gut | N/A | heterozygote | 0.0% (0 of 2) |
| Handplate | N/A | heterozygote | 0.0% (0 of 3) |
| Head | N/A | heterozygote | 0.0% (0 of 3) |
| Heart | N/A | heterozygote | 0.0% (0 of 3) |
| Hindbrain | N/A | heterozygote | 66.67% (2 of 3) |
| Hindlimb | N/A | heterozygote | 0.0% (0 of 3) |
| Liver | N/A | heterozygote | 0.0% (0 of 3) |
| Lung | N/A | heterozygote | 0.0% (0 of 3) |
| Mandibular process | N/A | heterozygote | 0.0% (0 of 3) |
| Maxillary process | N/A | heterozygote | 0.0% (0 of 3) |
| Midbrain | N/A | heterozygote | 66.67% (2 of 3) |
| Nose | N/A | heterozygote | 0.0% (0 of 2) |
| Oral cavity | N/A | heterozygote | 0.0% (0 of 3) |
| Skeleton | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 0.0% (0 of 3) |
| Spinal cord | N/A | heterozygote | 100% (2 of 2) |
| Tail somite | N/A | heterozygote | 0.0% (0 of 3) |
| Tail | N/A | heterozygote | 0.0% (0 of 3) |
| Trachea | N/A | heterozygote | 0.0% (0 of 2) |
| Urinary system | N/A | heterozygote | 0.0% (0 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.0% |
| aorta | 0.0% |
| brain | 0.0% |
| brainstem | 0.0% |
| cartilage tissue | 0.0% |
| cerebellum | 0.0% |
| cerebral cortex | 0.0% |
| esophagus | 0.0% |
| eye | 0.0% |
| heart | 0.0% |
| hippocampus | 0.0% |
| hypothalamus | 0.0% |
| kidney | 0.0% |
| large intestine | 0.0% |
| liver | 0.0% |
| lower urinary tract | 0.0% |
| lung | 0.0% |
| lymph node | 0.0% |
| mammary gland | 0.0% |
| olfactory lobe | 0.0% |
| ovary | 0.0% |
| oviduct | 0.0% |
| pancreas | 0.0% |
| peripheral nervous system | 0.0% |
| peyers patch | 0.0% |
| pituitary gland | 0.0% |
| prostate gland | 0.0% |
| skeletal muscle | 0.0% |
| skin | 0.0% |
| small intestine | 0.0% |
| spinal cord | 0.0% |
| spleen | 0.0% |
| stomach | 0.0% |
| striatum | 0.0% |
| testis | 0.0% |
| thymus | 0.0% |
| thyroid gland | 0.0% |
| trachea | 0.0% |
| uterus | 0.0% |
| vascular system | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| axial skeleton | Ambiguous |
| brain | 0.0% |
| central nervous system ganglion | Ambiguous |
| ear | 0.0% |
| embryo | 0.0% |
| eye | 0.0% |
| footplate | 0.0% |
| forebrain | 0.0% |
| forelimb | 0.0% |
| gut | Ambiguous |
| handplate | 0.0% |
| head | 0.0% |
| heart | 0.0% |
| hindbrain | 0.0% |
| hindlimb | 0.0% |
| liver | 0.0% |
| lung | 0.0% |
| mandibular process | 0.0% |
| maxillary process | 0.0% |
| midbrain | 0.0% |
| nose | Ambiguous |
| oral cavity | 0.0% |
| skeleton | Ambiguous |
| skin | 0.0% |
| spinal cord | Ambiguous |
| tail | 0.0% |
| tail somite group | 0.0% |
| trachea | Ambiguous |
| urinary system | Ambiguous |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
XRay Images Whole Body Dorso Ventral
16 Images
XRay Images Skull Dorso Ventral Orientation
16 Images
XRay Images Hind Leg and Hip
16 Images
XRay Images Skull Lateral Orientation
16 Images
Images
8 Images
Images Slit Lamp
3 Images
LacZ Images Section
16 Images
XRay Images Whole Body Lateral Orientation
16 Images
LacZ images wholemount
12 Images
Images Ophthalmoscopy
3 Images
Images
1 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for 1700003F12Rik
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| MGI Allele | Allele Type | Produced |
|---|---|---|
| 1700003F12Riktm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
| 1700003F12Riktm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
| 1700003F12Riktm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
| 1700003F12Riktm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
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