Gene Summary

Name:
importin 9
Synonyms:
0710008K06Rik,  Imp9

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
edema Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal chorioallantoic fusion Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal forebrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal heart morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
preweaning lethality, complete penetrance Ipo9em1(IMPC)Bay HOM   Early adult 0.00
abnormal vitelline vasculature morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Ipo9em1(IMPC)Bay HOM   E12.5 0.00
abnormal pharyngeal arch morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal tail bud morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal allantois morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic growth retardation Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo turning Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo size Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal neural tube closure Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal midbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal hindbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left fundus

17 Images

Eye Morphology

VIP of left eye

17 Images

Eye Morphology

VIP of right fundus

17 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Eye Morphology

VIP of right eye

17 Images

MicroCT E9.5

Embryo reconstruction

7 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Ipo9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ipo9 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lambert Syndrome
Ventricular septal defect, Intrauterine growth retardation, Branchial anomaly ORPHA:1296
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
X-Linked Mandibulofacial Dysostosis
Abnormal mitral valve morphology, Short stature, Pulmonic stenosis, Branchial anomaly, Webbed neck ORPHA:1131
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature OMIM:609166
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Bicuspid aortic valve, Atrial septal defect, Atrioventricular canal defect, Ventricular septal de... ORPHA:453499
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst, Severe postnatal growth retardation ORPHA:435938
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature ORPHA:50815
Aminopterin/Methotrexate Embryofetopathy
Hydrocephalus, Holoprosencephaly, Short stature, Anencephaly, Tetralogy of Fallot, Ventricular se... ORPHA:1908
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Holoprosencephaly
Abnormal pulmonary valve morphology, Hydrocephalus, Holoprosencephaly, Short neck, Tetralogy of F... ORPHA:2162
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Distal 22Q11.2 Microduplication Syndrome
Tricuspid valve prolapse, Hydrocephalus, Branchial fistula, Palpebral edema, Ventricular septal d... ORPHA:261337
Oligomeganephronia
Branchial cyst, Dehydration, Secundum atrial septal defect ORPHA:2260
Posterior Meningocele
Occipital meningocele, Hydrocephalus, Neural tube defect, Limitation of neck motion, Meningocele,... ORPHA:268810
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Bor Syndrome
Branchial cyst ORPHA:107
Distal 22Q11.2 Microdeletion Syndrome
Atrial septal defect, Short stature, Branchial fistula, Ventricular septal defect, Growth delay, ... ORPHA:261330
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Bicuspid aortic valve, Atrial septal defect, Ventricular septal defect, Cystic hygroma, Branchial... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Bicuspid aortic valve, Atrial septal defect, Ventricular septal defect, Cystic hygroma, Branchial... ORPHA:352665
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Mitral stenosis, Atrial septal defect, Hypoplastic left heart, Aortic valve stenosis, Short statu... OMIM:617660
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Treacher-Collins Syndrome
Encephalocele, Patent ductus arteriosus, Branchial fistula ORPHA:861
Iniencephaly
Myelomeningocele, Hydrocephalus, Holoprosencephaly, Anencephaly, Polyhydramnios, Spinal dysraphis... ORPHA:63259
8Q24.3 Microdeletion Syndrome
Atrioventricular canal defect, Short stature, Short neck, Spina bifida occulta, Ventricular septa... ORPHA:508488
Craniofacial Microsomia
Hydrocephalus, Tetralogy of Fallot, Ventricular septal defect, Patent ductus arteriosus, Branchia... OMIM:164210
Branchiooculofacial Syndrome
Short neck, Branchial anomaly, Postnatal growth retardation, Intrauterine growth retardation, Low... OMIM:113620
Witteveen-Kolk Syndrome
Short stature, Branchial fistula, Polyhydramnios, Growth delay, Intrauterine growth retardation OMIM:613406
Alobar Holoprosencephaly
Hydrocephalus, Short stature, Neural tube defect, Growth delay, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Short stature, Neural tube defect, Growth delay, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Short stature, Neural tube defect, Growth delay, Abnormal heart morphology ORPHA:93924
Semilobar Holoprosencephaly
Hydrocephalus, Short stature, Neural tube defect, Growth delay, Abnormal heart morphology ORPHA:220386
Schinzel-Giedion Syndrome
Short neck, Delayed eruption of teeth, Neural tube defect, Umbilical hernia, Abnormal heart morph... ORPHA:798

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ipo9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ipo9.

No publications found that use IMPC mice or data for Ipo9.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ipo9tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ipo9tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9em1(IMPC)Bay Exon Deletion Mice
Ipo9tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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