Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
period circadian clock 1
Synonyms:
Hftm,  m-rigui,  mPer1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Per1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Per1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity, Short attention span DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity, Short attention span OMIM:608443
Oocyte/Zygote/Embryo Maturation Arrest 9
Oocyte arrest at metaphase I, Female infertility, Abnormality of the menstrual cycle OMIM:619011
Asherman Syndrome
Secondary amenorrhea, Infertility, Oligomenorrhea, Dysmenorrhea, Abnormality of the menstrual cyc... ORPHA:137686
Schizophrenia 15
Hyperactivity OMIM:613950
Endometriosis, Susceptibility To, 1
Dysmenorrhea, Decreased fertility, Endometriosis OMIM:131200
Premature Ovarian Failure 19
Secondary amenorrhea, Premature ovarian insufficiency, Irregular menstruation, Female infertility OMIM:619245
Oocyte/Zygote/Embryo Maturation Arrest 8
Female infertility, Abnormality of the menstrual cycle OMIM:619009
Invasive Mole
Menometrorrhagia ORPHA:99925
Hyperprolactinemia
Oligomenorrhea, Menorrhagia, Female infertility OMIM:615555
Premature Ovarian Failure 2B
Premature ovarian insufficiency, Female infertility, Primary amenorrhea OMIM:300604
Gestational Choriocarcinoma
Metrorrhagia ORPHA:99926
Placental Site Trophoblastic Tumor
Metrorrhagia, Amenorrhea ORPHA:99928
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Familial Hyperprolactinemia
Infertility, Female hypogonadism, Oligomenorrhea, Menorrhagia, Amenorrhea ORPHA:397685
Leptin Deficiency Or Dysfunction
Obesity, Polyphagia, Hypogonadism, Primary amenorrhea OMIM:614962
Narcolepsy 3
Narcolepsy OMIM:609039
Oocyte/Zygote/Embryo Maturation Arrest 17
Amenorrhea, Female infertility OMIM:620319
Oocyte/Zygote/Embryo Maturation Arrest 20
Amenorrhea, Female infertility OMIM:620383
Premature Ovarian Failure 1
Premature ovarian insufficiency, Irregular menstruation OMIM:311360
Gordon Holmes Syndrome
Secondary amenorrhea, Oligomenorrhea, Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:212840
Cortisone Reductase Deficiency 1
Oligomenorrhea, Obesity, Infertility OMIM:604931
Polycystic Ovary Syndrome 1
Oligomenorrhea, Amenorrhea, Obesity OMIM:184700
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Premature Ovarian Failure 12
Primary amenorrhea OMIM:616947
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
46,Xy Gonadal Dysgenesis With Minifascicular Neuropathy
Primary amenorrhea, Hypergonadotropic hypogonadism OMIM:607080
Ovarian Dysgenesis 4
Decreased body weight, Primary amenorrhea OMIM:616185
Narcolepsy 1
Narcolepsy OMIM:161400
Premature Ovarian Failure 15
Secondary amenorrhea, Oligomenorrhea, Irregular menstruation OMIM:618096
Hypothyroidism, Congenital, Nongoitrous, 8
Secondary amenorrhea, Attention deficit hyperactivity disorder OMIM:301033
Peritoneal Cystic Mesothelioma
Metrorrhagia, Menorrhagia, Dyspareunia, Weight loss ORPHA:168816
Narcolepsy 7
Narcolepsy OMIM:614250
Premature Ovarian Failure 22
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility OMIM:620548
Prolactin Deficiency, Isolated
Infertility, Irregular menstruation OMIM:264110
Perrault Syndrome 6
Premature ovarian insufficiency, Secondary amenorrhea, Primary amenorrhea, Streak ovary, Irregula... OMIM:617565
Premature Ovarian Failure 11
Secondary amenorrhea, Oligomenorrhea OMIM:616946
Premature Ovarian Failure 5
Premature ovarian insufficiency, Secondary amenorrhea, Hypoplasia of the ovary, Reduced antral fo... OMIM:611548
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Amenorrhea, Premature ovarian insufficiency OMIM:619425
Gray Platelet Syndrome
Abnormality of the menstrual cycle ORPHA:721
Osteopetrosis, Autosomal Dominant 1
Generalized osteosclerosis, Osteopetrosis, Calvarial osteosclerosis, Thickened cortex of long bones OMIM:607634
Premature Ovarian Failure 3
Secondary amenorrhea, Premature ovarian insufficiency OMIM:608996
Premature Ovarian Failure 13
Oligomenorrhea, Amenorrhea, Female infertility OMIM:617442
Ovarian Dysgenesis 2
Premature ovarian insufficiency, Secondary amenorrhea, Hypergonadotropic hypogonadism, Primary am... OMIM:300510
Ovarian Dysgenesis 1
Primary amenorrhea OMIM:233300
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia, Obesity, Truncal obesity, Irregular menstruation OMIM:615986
Premature Ovarian Failure 2A
Secondary amenorrhea, Premature ovarian insufficiency OMIM:300511
Perrault Syndrome 2
Amenorrhea, Streak ovary OMIM:614926
Ovarian Dysgenesis 6
Primary amenorrhea, Hypergonadotropic hypogonadism OMIM:618078
Retinal Dystrophy With Or Without Extraocular Anomalies
Secondary amenorrhea, Premature ovarian insufficiency OMIM:617175
Premature Ovarian Failure 6
Premature ovarian insufficiency, Secondary amenorrhea, Female infertility, Primary amenorrhea, St... OMIM:612310
Premature Ovarian Failure 9
Hypoplasia of the ovary, Amenorrhea, Premature ovarian insufficiency OMIM:615724
Premature Ovarian Failure 18
Secondary amenorrhea, Hypoplasia of the ovary, Premature ovarian insufficiency, Irregular menstru... OMIM:619203
Premature Ovarian Failure 20
Secondary amenorrhea, Female infertility OMIM:619938
Hemochromatosis, Type 2A
Amenorrhea, Infertility, Hypogonadotropic hypogonadism, Azoospermia OMIM:602390
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:614858
Isolated Follicle Stimulating Hormone Deficiency
Male hypogonadism, Azoospermia, Oligozoospermia, Delayed menarche, Testicular atrophy, Female hyp... ORPHA:52901
Perrault Syndrome 4
Premature ovarian insufficiency, Hypoplasia of the ovary, Secondary amenorrhea, Oligomenorrhea, O... OMIM:615300
Wilson Disease
Increased body weight, Failure to thrive, Weight loss, Abnormality of the menstrual cycle, Hypers... ORPHA:905
Premature Ovarian Failure 7
Secondary amenorrhea, Premature ovarian insufficiency, Primary amenorrhea OMIM:612964
Double Uterus-Hemivagina-Renal Agenesis Syndrome
Metrorrhagia, Dysmenorrhea, Dyspareunia ORPHA:3411
Luscan-Lumish Syndrome
Obesity, Polyphagia, Irregular menstruation, Aggressive behavior OMIM:616831
Plin1-Related Familial Partial Lipodystrophy
Oligomenorrhea, Infertility ORPHA:280356
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Primary amenorrhea, Infertility, Hypogonadism, Azoospermia OMIM:229070
Ovarian Dysgenesis 8
Eunuchoid habitus, Primary amenorrhea OMIM:618187
Craniometaphyseal Dysplasia
Osteopetrosis, Craniofacial hyperostosis ORPHA:1522
Familial Afibrinogenemia
Menometrorrhagia ORPHA:98880
Ovarian Dysgenesis 10
Hypoplasia of the ovary, Premature ovarian insufficiency, Streak ovary, Primary amenorrhea OMIM:619834
Osteopetrosis, Autosomal Recessive 9
Increased bone mineral density, Osteopetrosis, Cortical sclerosis OMIM:620366
Glanzmann Thrombasthenia
Menorrhagia, Menometrorrhagia ORPHA:849
Premature Ovarian Failure 21
Secondary amenorrhea, Streak ovary, Primary amenorrhea OMIM:620311
Osteopetrosis, Autosomal Dominant 2
Generalized osteosclerosis, Osteopetrosis OMIM:166600
Hemochromatosis, Type 3
Amenorrhea, Hypogonadotropic hypogonadism, Impotence OMIM:604250
Premature Ovarian Failure 10
Hypoplasia of the ovary, Premature ovarian insufficiency, Primary amenorrhea, Azoospermia OMIM:612885
Premature Ovarian Failure 14
Primary amenorrhea OMIM:618014
Premature Ovarian Failure 8
Premature ovarian insufficiency, Streak ovary, Primary amenorrhea OMIM:615723
Proprotein Convertase 1/3 Deficiency
Obesity, Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:600955
Pituicytoma
Amenorrhea, Decreased female libido, Impotence, Hypogonadotropic hypogonadism ORPHA:251623
Lipodystrophy, Familial Partial, Type 4
Oligomenorrhea OMIM:613877
Lead Poisoning
Anorexia, Decreased male libido, Infertility, Oligozoospermia, Reduced sperm motility, Abnormalit... ORPHA:330015
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Adrenal pheochromocytoma, Carotid paraganglio... OMIM:168000
Hydatidiform Mole
Menometrorrhagia ORPHA:99927
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Pheochromocytoma/Paraganglioma Syndrome 3
Chemodectoma, Adrenal pheochromocytoma, Elevated circulating catecholamine level, Paraganglioma, ... OMIM:605373
46,Xy Sex Reversal 1
Primary amenorrhea, Abnormality of the menstrual cycle, Hypergonadotropic hypogonadism OMIM:400044
Osteopetrosis, Autosomal Recessive 4
Increased bone mineral density, Osteopetrosis OMIM:611490
Fowler Urethral Sphincter Dysfunction Syndrome
Oligomenorrhea, Menorrhagia, Amenorrhea ORPHA:2795
Osteopetrosis, Autosomal Recessive 8
Osteopetrosis OMIM:615085
Glucocorticoid Resistance, Generalized
Infertility, Irregular menstruation OMIM:615962
Pituitary Dermoid And Epidermoid Cysts
Polydipsia, Oligozoospermia, Oligomenorrhea, Hypogonadism, Amenorrhea ORPHA:91351
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Azoospermia, Secondary amenorrhea, Abnormal spermatogenesis, Oligomenorrhea, Male hypogonadism, H... OMIM:228300
Ovarian Dysgenesis 3
Female infertility, Primary amenorrhea OMIM:614324
Prolactinoma
Male hypogonadism, Erectile dysfunction, Decreased fertility in males, Dyspareunia, Impotence, Fe... ORPHA:2965
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Hypogonadotropic hypogonadism, Primary amenorrhea OMIM:614839
Osteopetrosis, Autosomal Recessive 2
Cranial hyperostosis, Osteopetrosis, Decreased osteoclast count, Diaphyseal sclerosis OMIM:259710
Gangliocytoma
Amenorrhea, Decreased female libido, Polyphagia, Impotence ORPHA:251937
Functioning Gonadotropic Adenoma
Infertility, Oligozoospermia, Impotence, Abnormality of the menstrual cycle, Amenorrhea, Decrease... ORPHA:91348
Aromatase Deficiency
Primary amenorrhea, Hypergonadotropic hypogonadism OMIM:613546
Lipodystrophy, Familial Partial, Type 5
Irregular menstruation OMIM:615238
Pituitary Adenoma 1, Multiple Types
Irregular menstruation OMIM:102200
Wolfram Syndrome 2
Oligomenorrhea, Primary amenorrhea OMIM:604928
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Pituitary Adenoma 4, Acth-Secreting
Oligomenorrhea, Obesity, Abnormal fear-induced behavior, Abdominal obesity OMIM:219090
Akt2-Related Familial Partial Lipodystrophy
Oligomenorrhea ORPHA:79085
Non-Functioning Pituitary Adenoma
Male hypogonadism, Erectile dysfunction, Decreased fertility in males, Impotence, Female hypogona... ORPHA:91349
Klippel-Trénaunay Syndrome
Abnormality of the menstrual cycle ORPHA:90308
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis OMIM:612840
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Increased bone mineral density, Osteopetrosis OMIM:617306
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Hermansky-Pudlak Syndrome 5
Metrorrhagia, Menorrhagia OMIM:614074
Hypopigmentation, Organomegaly, And Delayed Myelination And Development
Osteopetrosis OMIM:618541
Osteopetrosis, Autosomal Recessive 3
Cranial hyperostosis, Osteopetrosis, Diaphyseal sclerosis OMIM:259730
Osteopetrosis, Autosomal Recessive 1
Increased bone mineral density, Craniosynostosis, Osteopetrosis, Calvarial osteosclerosis OMIM:259700
Neuroblastoma
Elevated circulating catecholamine level, Ataxia, Antalgic gait ORPHA:635
Osteopathia Striata-Cranial Sclerosis Syndrome
Increased bone mineral density, Osteopetrosis, Coarse metaphyseal trabecularization, Facial hyper... ORPHA:2780
Interstitial Cystitis
Dyspareunia, Abnormality of the menstrual cycle ORPHA:37202
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Craniofacial osteosclerosis, Osteopetrosis, Increased skull ossification, Diaphyseal sclerosis OMIM:618476
Tsh-Secreting Pituitary Adenoma
Male hypogonadism, Erectile dysfunction, Decreased fertility in males, Infertility, Impotence, Fe... ORPHA:91347
Osteopetrosis, Autosomal Recessive 5
Increased bone mineral density, Cranial hyperostosis, Osteopetrosis, Decreased osteoclast count OMIM:259720
Malakoplakia
Orchitis, Abnormality of the menstrual cycle ORPHA:556
Desmosterolosis
Increased bone mineral density, Osteopetrosis ORPHA:35107
Osteopetrosis, Autosomal Recessive 7
Osteopetrosis, Abnormal trabecular bone morphology OMIM:612301
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Abnormal ovarian physiology, Oligomenorrhea, Failure to thrive, Abnormality of the menstrual cycl... ORPHA:90794
Lenz-Majewski Hyperostotic Dwarfism
Cranial hyperostosis, Osteopetrosis, Abnormal cortical bone morphology, Increased bone mineral de... ORPHA:2658
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Adrenal pheochromocytoma, Pancreatic islet cell adenoma, Elevated cir... ORPHA:892
Autosomal Recessive Malignant Osteopetrosis
Craniosynostosis, Osteopetrosis, Reduced bone mineral density ORPHA:667
African Trypanosomiasis
Infertility, Impotence, Weight loss, Abnormality of the menstrual cycle, Aggressive behavior ORPHA:3385
Wiskott-Aldrich Syndrome
Abnormality of the menstrual cycle ORPHA:906
Osteopetrosis With Renal Tubular Acidosis
Osteopetrosis ORPHA:2785

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Per1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Per1.

No publications found that use IMPC mice or data for Per1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Per1tm444593(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Per1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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