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Gene: Per1 MGI:1098283

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
period circadian clock 1
Synonyms:
Hftm,  m-rigui,  mPer1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Per1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Per1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Short attention span, Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Short attention span, Hyperactivity OMIM:608443
Asherman Syndrome
Metrorrhagia, Dysmenorrhea, Abnormality of the menstrual cycle, Decreased fertility in females, S... ORPHA:137686
Schizophrenia 15
Hyperactivity OMIM:613950
Endometriosis, Susceptibility To, 1
Decreased fertility, Dysmenorrhea, Endometriosis OMIM:131200
Premature Ovarian Failure 19
Secondary amenorrhea, Premature ovarian insufficiency, Irregular menstruation, Female infertility OMIM:619245
Invasive Mole
Menometrorrhagia ORPHA:99925
Hyperprolactinemia
Menorrhagia, Oligomenorrhea, Female infertility OMIM:615555
Premature Ovarian Failure 2B
Premature ovarian insufficiency, Primary amenorrhea, Female infertility OMIM:300604
Gestational Choriocarcinoma
Metrorrhagia ORPHA:99926
Placental Site Trophoblastic Tumor
Metrorrhagia, Amenorrhea ORPHA:99928
Narcolepsy 3
Narcolepsy OMIM:609039
Osteopetrosis, Autosomal Recessive 6
Osteopetrosis OMIM:611497
Leptin Deficiency Or Dysfunction
Obesity, Primary amenorrhea, Hypogonadism, Polyphagia, Decreased testicular size OMIM:614962
Familial Hyperprolactinemia
Female hypogonadism, Menorrhagia, Infertility, Oligomenorrhea, Amenorrhea ORPHA:397685
Oocyte/Zygote/Embryo Maturation Arrest 17
Female infertility, Amenorrhea OMIM:620319
Oocyte/Zygote/Embryo Maturation Arrest 20
Female infertility, Amenorrhea OMIM:620383
Narcolepsy 1
Narcolepsy OMIM:161400
Premature Ovarian Failure 1
Premature ovarian insufficiency, Irregular menstruation OMIM:311360
Cortisone Reductase Deficiency 1
Infertility, Obesity, Oligomenorrhea OMIM:604931
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Gordon Holmes Syndrome
Secondary amenorrhea, Hypogonadotropic hypogonadism, Oligomenorrhea, Primary amenorrhea OMIM:212840
Polycystic Ovary Syndrome 1
Amenorrhea, Obesity, Oligomenorrhea OMIM:184700
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Premature Ovarian Failure 12
Primary amenorrhea OMIM:616947
Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
Cryptorchidism, Hypogonadotropic hypogonadism, Decreased testicular size, Primary amenorrhea OMIM:614840
Ovarian Dysgenesis 4
Primary amenorrhea, Decreased body weight OMIM:616185
Narcolepsy 7
Narcolepsy OMIM:614250
Premature Ovarian Failure 15
Irregular menstruation, Oligomenorrhea, Secondary amenorrhea OMIM:618096
Hypothyroidism, Congenital, Nongoitrous, 8
Attention deficit hyperactivity disorder, Secondary amenorrhea OMIM:301033
Osteopetrosis, Autosomal Dominant 1
Thickened cortex of long bones, Generalized osteosclerosis, Calvarial osteosclerosis, Osteopetrosis OMIM:607634
Peritoneal Cystic Mesothelioma
Menorrhagia, Dyspareunia, Metrorrhagia, Weight loss ORPHA:168816
Prolactin Deficiency, Isolated
Irregular menstruation, Infertility OMIM:264110
Perrault Syndrome 6
Streak ovary, Premature ovarian insufficiency, Irregular menstruation, Secondary amenorrhea, Prim... OMIM:617565
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Premature ovarian insufficiency, Amenorrhea OMIM:619425
Premature Ovarian Failure 5
Streak ovary, Premature ovarian insufficiency, Primary amenorrhea, Secondary amenorrhea, Hypoplas... OMIM:611548
Premature Ovarian Failure 11
Oligomenorrhea, Secondary amenorrhea OMIM:616946
Gray Platelet Syndrome
Abnormality of the menstrual cycle ORPHA:721
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Hypogonadotropic hypogonadism, Cryptorchidism, Primary amenorrhea, Infertility, Decreased testicu... OMIM:146110
Premature Ovarian Failure 13
Oligomenorrhea, Female infertility, Amenorrhea OMIM:617442
Premature Ovarian Failure 3
Premature ovarian insufficiency, Secondary amenorrhea OMIM:608996
Ovarian Dysgenesis 2
Streak ovary, Premature ovarian insufficiency, Hypergonadotropic hypogonadism, Primary amenorrhea... OMIM:300510
Ovarian Dysgenesis 1
Primary amenorrhea OMIM:233300
Bardet-Biedl Syndrome 9
Irregular menstruation, Obesity, Truncal obesity, Polydipsia, Polyphagia OMIM:615986
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Cryptorchidism, Hypogonadotropic hypogonadism, Decreased testicular size, Primary amenorrhea OMIM:614858
Premature Ovarian Failure 2A
Premature ovarian insufficiency, Secondary amenorrhea OMIM:300511
Perrault Syndrome 2
Streak ovary, Amenorrhea OMIM:614926
Retinal Dystrophy With Or Without Extraocular Anomalies
Premature ovarian insufficiency, Secondary amenorrhea OMIM:617175
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Primary amenorrhea, Azoospermia, Hypogonadism, Infertility, Decreased testicular size OMIM:229070
Ovarian Dysgenesis 6
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:618078
Premature Ovarian Failure 6
Streak ovary, Premature ovarian insufficiency, Female infertility, Secondary amenorrhea, Primary ... OMIM:612310
Premature Ovarian Failure 9
Premature ovarian insufficiency, Hypoplasia of the ovary, Amenorrhea OMIM:615724
Premature Ovarian Failure 20
Secondary amenorrhea, Female infertility OMIM:619938
Premature Ovarian Failure 18
Premature ovarian insufficiency, Irregular menstruation, Secondary amenorrhea, Hypoplasia of the ... OMIM:619203
Hemochromatosis, Type 2A
Azoospermia, Hypogonadotropic hypogonadism, Infertility, Amenorrhea OMIM:602390
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Hypogonadotropic hypogonadism, Cryptorchidism, Obesity, Primary amenorrhea, Decreased testicular ... OMIM:610628
Isolated Follicle Stimulating Hormone Deficiency
Hyperplasia of the Leydig cells, Decreased female libido, Hypogonadotropic hypogonadism, Female h... ORPHA:52901
Perrault Syndrome 4
Premature ovarian insufficiency, Obesity, Secondary amenorrhea, Primary amenorrhea, Hypoplasia of... OMIM:615300
Wilson Disease
Abnormality of the menstrual cycle, Aggressive behavior, Hypersexuality, Increased body weight, W... ORPHA:905
Premature Ovarian Failure 7
Premature ovarian insufficiency, Primary amenorrhea, Secondary amenorrhea OMIM:612964
Premature Ovarian Failure 10
Premature ovarian insufficiency, Primary amenorrhea, Azoospermia, Hypoplasia of the ovary, Decrea... OMIM:612885
Double Uterus-Hemivagina-Renal Agenesis Syndrome
Dyspareunia, Metrorrhagia, Dysmenorrhea ORPHA:3411
Plin1-Related Familial Partial Lipodystrophy
Infertility, Oligomenorrhea ORPHA:280356
Luscan-Lumish Syndrome
Polyphagia, Irregular menstruation, Obesity, Aggressive behavior OMIM:616831
Craniometaphyseal Dysplasia
Craniofacial hyperostosis, Osteopetrosis ORPHA:1522
Ovarian Dysgenesis 8
Eunuchoid habitus, Primary amenorrhea OMIM:618187
Familial Afibrinogenemia
Menometrorrhagia ORPHA:98880
Osteopetrosis, Autosomal Recessive 9
Increased bone mineral density, Osteopetrosis, Cortical sclerosis OMIM:620366
Ovarian Dysgenesis 10
Streak ovary, Premature ovarian insufficiency, Primary amenorrhea, Hypoplasia of the ovary OMIM:619834
Osteopetrosis, Autosomal Dominant 2
Generalized osteosclerosis, Osteopetrosis OMIM:166600
Premature Ovarian Failure 21
Streak ovary, Primary amenorrhea, Secondary amenorrhea OMIM:620311
Premature Ovarian Failure 14
Primary amenorrhea OMIM:618014
Hemochromatosis, Type 3
Impotence, Hypogonadotropic hypogonadism, Amenorrhea OMIM:604250
Premature Ovarian Failure 8
Streak ovary, Premature ovarian insufficiency, Primary amenorrhea OMIM:615723
Proprotein Convertase 1/3 Deficiency
Hypogonadotropic hypogonadism, Obesity, Primary amenorrhea OMIM:600955
Pituicytoma
Impotence, Decreased female libido, Hypogonadotropic hypogonadism, Amenorrhea ORPHA:251623
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, Glomus tympan... OMIM:168000
Lipodystrophy, Familial Partial, Type 4
Oligomenorrhea OMIM:613877
Pheochromocytoma/Paraganglioma Syndrome 3
Extraadrenal pheochromocytoma, Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Para... OMIM:605373
Hydatidiform Mole
Menometrorrhagia ORPHA:99927
Lead Poisoning
Decreased female libido, Small for gestational age, Anorexia, Abnormality of the menstrual cycle,... ORPHA:330015
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Hypogonadotropic hypogonadism, Secondary amenorrhea, Abnormal spermatogenesis, Azoospermia, Oligo... OMIM:228300
46,Xy Sex Reversal 1
Hypergonadotropic hypogonadism, Primary amenorrhea, Abnormality of the menstrual cycle OMIM:400044
Osteopetrosis, Autosomal Recessive 4
Increased bone mineral density, Osteopetrosis OMIM:611490
Osteopetrosis, Autosomal Recessive 8
Osteopetrosis OMIM:615085
Fowler Urethral Sphincter Dysfunction Syndrome
Menorrhagia, Oligomenorrhea, Amenorrhea ORPHA:2795
Glucocorticoid Resistance, Generalized
Irregular menstruation, Infertility OMIM:615962
Pituitary Dermoid And Epidermoid Cysts
Oligozoospermia, Hypogonadism, Oligomenorrhea, Polydipsia, Amenorrhea ORPHA:91351
Prolactinoma
Dyspareunia, Decreased female libido, Hypogonadotropic hypogonadism, Female hypogonadism, Abnorma... ORPHA:2965
Functioning Gonadotropic Adenoma
Macroorchidism, postpubertal, Decreased female libido, Abnormality of the menstrual cycle, Oligoz... ORPHA:91348
Ovarian Dysgenesis 3
Primary amenorrhea, Female infertility OMIM:614324
Osteopetrosis, Autosomal Recessive 2
Osteopetrosis, Cranial hyperostosis, Decreased osteoclast count, Diaphyseal sclerosis OMIM:259710
Gangliocytoma
Impotence, Decreased female libido, Polyphagia, Amenorrhea ORPHA:251937
Interstitial Cystitis
Dyspareunia, Abnormality of the menstrual cycle ORPHA:37202
Lipodystrophy, Familial Partial, Type 5
Irregular menstruation OMIM:615238
Aromatase Deficiency
Hypergonadotropic hypogonadism, Primary amenorrhea OMIM:613546
Mayer-Rokitansky-Kuster-Hauser Syndrome
Amenorrhea OMIM:277000
Non-Functioning Pituitary Adenoma
Macroorchidism, postpubertal, Decreased female libido, Hypogonadotropic hypogonadism, Female hypo... ORPHA:91349
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Akt2-Related Familial Partial Lipodystrophy
Oligomenorrhea ORPHA:79085
Leukocyte Adhesion Deficiency, Type Iii
Osteopetrosis OMIM:612840
Klippel-Trénaunay Syndrome
Abnormality of the menstrual cycle ORPHA:90308
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness
Increased bone mineral density, Osteopetrosis OMIM:617306
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Blepharophimosis, Ptosis, And Epicanthus Inversus
Premature ovarian insufficiency, Irregular menstruation, Female infertility, Amenorrhea OMIM:110100
Hypopigmentation, Organomegaly, And Delayed Myelination And Development
Osteopetrosis OMIM:618541
Osteopetrosis, Autosomal Recessive 1
Increased bone mineral density, Calvarial osteosclerosis, Osteopetrosis, Craniosynostosis OMIM:259700
Hermansky-Pudlak Syndrome 5
Menorrhagia, Metrorrhagia OMIM:614074
Osteopetrosis, Autosomal Recessive 3
Osteopetrosis, Cranial hyperostosis, Diaphyseal sclerosis OMIM:259730
Wolfram Syndrome 2
Oligomenorrhea, Primary amenorrhea OMIM:604928
Osteopathia Striata-Cranial Sclerosis Syndrome
Facial hyperostosis, Increased bone mineral density, Osteopetrosis, Coarse metaphyseal trabecular... ORPHA:2780
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Osteopetrosis, Increased skull ossification, Craniofacial osteosclerosis, Diaphyseal sclerosis OMIM:618476
Tsh-Secreting Pituitary Adenoma
Decreased female libido, Hypogonadotropic hypogonadism, Female hypogonadism, Abnormality of the m... ORPHA:91347
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Osteopetrosis ORPHA:3240
Osteopetrosis, Autosomal Recessive 5
Increased bone mineral density, Cranial hyperostosis, Decreased osteoclast count, Osteopetrosis OMIM:259720
Desmosterolosis
Increased bone mineral density, Osteopetrosis ORPHA:35107
Malakoplakia
Orchitis, Abnormality of the menstrual cycle ORPHA:556
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hypogonadotropic hypogonadism, Abnormality of the menstrual cycle, Decreased fertility, Testicula... ORPHA:90794
Osteopetrosis, Autosomal Recessive 7
Abnormal trabecular bone morphology, Osteopetrosis OMIM:612301
Lenz-Majewski Hyperostotic Dwarfism
Increased bone mineral density, Cranial hyperostosis, Osteopetrosis, Facial hyperostosis, Abnorma... ORPHA:2658
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Von Hippel-Lindau Disease
Pancreatic islet cell adenoma, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paragangliom... ORPHA:892
Autosomal Recessive Malignant Osteopetrosis
Osteopetrosis, Craniosynostosis, Reduced bone mineral density ORPHA:667
African Trypanosomiasis
Aggressive behavior, Abnormality of the menstrual cycle, Weight loss, Impotence, Infertility ORPHA:3385
Wiskott-Aldrich Syndrome
Abnormality of the menstrual cycle ORPHA:906
Osteopetrosis With Renal Tubular Acidosis
Osteopetrosis ORPHA:2785
Hypermobile Ehlers-Danlos Syndrome
Decreased fertility, Abnormality of the menstrual cycle ORPHA:285

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Per1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Per1.

No publications found that use IMPC mice or data for Per1.

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MGI Allele Allele Type Produced
Per1tm444593(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Per1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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