Gene: Aqp1

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Phenotype System Allele Zyg Sex Life Stage P Value
hypoactivity Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 6.27×10-08
increased circulating HDL cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 2.68×10-05
impaired glucose tolerance Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 9.14×10-05
decreased exploration in new environment Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 1.02×10-10
increased circulating alkaline phosphatase level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 8.87×10-26
increased circulating cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 5.18×10-05
increased circulating amylase level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 7.99×10-06
decreased exploration in new environment Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 4.95×10-06
decreased total body fat amount Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 4.60×10-05
decreased body weight Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 5.26×10-05
hypoactivity Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 5.06×10-25
increased neutrophil cell number Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 9.86×10-05
decreased circulating chloride level Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 2.31×10-05
increased circulating total protein level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 2.64×10-07
increased lean body mass Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 4.09×10-05
decreased grip strength Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 1.05×10-10

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (1/2)  Wholemount images
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No  (1/2)  Wholemount images
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/590) N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/590) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/590)  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/590)  (2/2)  Wholemount images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (16/590)  Wholemount images
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (4/5) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (5/5) N/A
Eye 2  (1/506) N/A
Foot 2  (1/506) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506) N/A
Hand 2  (1/506) N/A
Head 2  (5/506)  (4/5) N/A
Heart 2  (1/506)  (2/5) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/506) N/A
Liver 2  (1/504)  (1/5) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Tail 2  (1/506) N/A
Tail somite 2  (1/506) N/A

 Associated Images

Echo: M-Mode Images
48 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
35 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Aqp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Aqp1tm44540(L1L2_st0) Targeting vectors
Aqp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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