2021 marked the 10th anniversary of the IMPC.
Over the last 10 years the output and impact of the Consortium has been formidable ranging from mouse mutant resources, novel disease models, comprehensive phenotype data and novel techological advances in mouse genetics. The new knowledge and resources created have had a transformative impact on the biomedical sciences and genomic medicine, including the identification of dark gene function, essential genes, sexual dimorphism, pleiotropy and multiple morbidities. The work of IMPC provides a fundamental underpinning to advances in our understanding of the mechanisms of disease and the development of novel therapeutic strategies.
The IMPC organised a series of workshops from October 2021 to April 2022 to celebrate the 10th anniversary and demonstrate:
- the remarkable, open access collections of phenotypic datasets in areas such as morphology, cardiovascular, metabolism, behaviour, pain
- the impact of the use of this data across biomedical discovery research and disease genetics
- the technological advances that have enabled the generation of this large-scale genetic resource
- the application of IMPC data and resources by numerous academic, not-for-profit and commercial entities thus leveraging the scientific value of the IMPC across the global biomedical science community
The IMPC has established a strong and timely strategy for the next decade. First, the IMPC is focusing over the next 2-3 years on the completion of the null mutant mouse resource. Second, the IMPC has an increasing focus on delivering broad-based genomic insights into the function of human genetic variation in both coding and non-coding sequences. Third, the consortium is increasingly bringing AI and machine learning approaches to the generation and analysis of phenotype data bringing new insights to genetic mechanisms and disease processes. Overall, the IMPC will continue to deliver and enhance mouse genetics approaches to genomic and precision medicine, rare disease, clinical genetics, and therapeutic opportunities.